First Case Reports of Nontuberculous Mycobacterial (NTM) Lung Disease in Ecuador: Important Lessons to Learn
Nontuberculous mycobacteria (NTM) lung infections are often misdiagnosed as tuberculosis, which can lead to ineffective antibiotic treatments. In this report, we present three cases of NTM lung infections in Ecuador that were initially diagnosed and treated as tuberculosis based on the results of sp...
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| Format: | info:ar-repo/semantics/artículo |
| Language: | Inglés |
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MDPI
2023
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| Online Access: | http://hdl.handle.net/20.500.12123/14457 https://www.mdpi.com/2076-0817/12/4/507 https://doi.org/10.3390/pathogens12040507 |
| _version_ | 1855037120411860992 |
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| author | Echeverria, Gustavo Rueda, Veronica Espinoza, Wilson Rosero, Carlos Zumarraga, Martin Jose Waard, Jacobus H. de |
| author_browse | Echeverria, Gustavo Espinoza, Wilson Rosero, Carlos Rueda, Veronica Waard, Jacobus H. de Zumarraga, Martin Jose |
| author_facet | Echeverria, Gustavo Rueda, Veronica Espinoza, Wilson Rosero, Carlos Zumarraga, Martin Jose Waard, Jacobus H. de |
| author_sort | Echeverria, Gustavo |
| collection | INTA Digital |
| description | Nontuberculous mycobacteria (NTM) lung infections are often misdiagnosed as tuberculosis, which can lead to ineffective antibiotic treatments. In this report, we present three cases of NTM lung infections in Ecuador that were initially diagnosed and treated as tuberculosis based on the results of sputum smear microscopy. The patients, all male, included two immunocompetent individuals and one HIV-positive subject. Unfortunately, sputum culture was not initiated until late in the course of the disease and the cause of the lung infection, Mycobacterium avium complex (MAC), was only identified after the patients had either passed away or were lost to follow-up. These cases are the first documented cases of NTM lung infections in the English medical literature from Ecuador. We emphasize the importance of accurate diagnosis of NTM infections by culture and identification to species level. Sputum smear staining alone cannot differentiate between mycobacterial species, which can lead to misidentification and ineffective treatments. Additionally, reporting NTM pulmonary disease as a notifiable disease to national TB control programs is recommended to obtain accurate prevalence data. These data are critical in determining the importance of this public health problem and the necessary actions needed to address it. |
| format | info:ar-repo/semantics/artículo |
| id | INTA14457 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI |
| publisherStr | MDPI |
| record_format | dspace |
| spelling | INTA144572023-04-12T16:34:31Z First Case Reports of Nontuberculous Mycobacterial (NTM) Lung Disease in Ecuador: Important Lessons to Learn Echeverria, Gustavo Rueda, Veronica Espinoza, Wilson Rosero, Carlos Zumarraga, Martin Jose Waard, Jacobus H. de Mycobacterium Enfermedades Pulmonares Diagnóstico Ecuador Pulmonary Diseases Tuberculosis Diagnosis Nontuberculous Mycobacteria Nontuberculous mycobacteria (NTM) lung infections are often misdiagnosed as tuberculosis, which can lead to ineffective antibiotic treatments. In this report, we present three cases of NTM lung infections in Ecuador that were initially diagnosed and treated as tuberculosis based on the results of sputum smear microscopy. The patients, all male, included two immunocompetent individuals and one HIV-positive subject. Unfortunately, sputum culture was not initiated until late in the course of the disease and the cause of the lung infection, Mycobacterium avium complex (MAC), was only identified after the patients had either passed away or were lost to follow-up. These cases are the first documented cases of NTM lung infections in the English medical literature from Ecuador. We emphasize the importance of accurate diagnosis of NTM infections by culture and identification to species level. Sputum smear staining alone cannot differentiate between mycobacterial species, which can lead to misidentification and ineffective treatments. Additionally, reporting NTM pulmonary disease as a notifiable disease to national TB control programs is recommended to obtain accurate prevalence data. These data are critical in determining the importance of this public health problem and the necessary actions needed to address it. Instituto de Biotecnología Fil: Echeverria, Gustavo. Universidad Central del Ecuador. Instituto de Investigación en Zoonosis-CIZ; Ecuador Fil: Echeverria, Gustavo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Programa de Doctorado; Argentina Fil: Echeverria, Gustavo. BioGENA. División Investigación y Desarrollo; Ecuador Fil: Rueda, Veronica. Universidad Central del Ecuador. Instituto de Investigación en Zoonosis-CIZ; Ecuador Fil: Espinoza, Wilson. Hospital de Especialidades Eugenio Espejo. Departamento de Tuberculosis; Ecuador Fil: Rosero, Carlos. Hospital de Especialidades Eugenio Espejo. Departamento de Tuberculosis; Ecuador Fil: Zumarraga, Martin Jose. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina Fil: Zumarraga, Martin Jose. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Waard, Jacobus H. de. Universidad Central de Venezuela. Instituto de Biomedicina “Jacinto Convit”. Departamento de Tuberculosis; Venezuela Fil: Waard, Jacobus H. de. Universidad de Las Américas. Facultad de Ciencias de la Salud. One Health Research Group; Ecuador 2023-04-12T16:31:59Z 2023-04-12T16:31:59Z 2023-04 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/14457 https://www.mdpi.com/2076-0817/12/4/507 2076-0817 https://doi.org/10.3390/pathogens12040507 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Ecuador .......... (nation) (World, South America) 1000051 MDPI Pathogens 12 (4) : 507. (April 2023) |
| spellingShingle | Mycobacterium Enfermedades Pulmonares Diagnóstico Ecuador Pulmonary Diseases Tuberculosis Diagnosis Nontuberculous Mycobacteria Echeverria, Gustavo Rueda, Veronica Espinoza, Wilson Rosero, Carlos Zumarraga, Martin Jose Waard, Jacobus H. de First Case Reports of Nontuberculous Mycobacterial (NTM) Lung Disease in Ecuador: Important Lessons to Learn |
| title | First Case Reports of Nontuberculous Mycobacterial (NTM) Lung Disease in Ecuador: Important Lessons to Learn |
| title_full | First Case Reports of Nontuberculous Mycobacterial (NTM) Lung Disease in Ecuador: Important Lessons to Learn |
| title_fullStr | First Case Reports of Nontuberculous Mycobacterial (NTM) Lung Disease in Ecuador: Important Lessons to Learn |
| title_full_unstemmed | First Case Reports of Nontuberculous Mycobacterial (NTM) Lung Disease in Ecuador: Important Lessons to Learn |
| title_short | First Case Reports of Nontuberculous Mycobacterial (NTM) Lung Disease in Ecuador: Important Lessons to Learn |
| title_sort | first case reports of nontuberculous mycobacterial ntm lung disease in ecuador important lessons to learn |
| topic | Mycobacterium Enfermedades Pulmonares Diagnóstico Ecuador Pulmonary Diseases Tuberculosis Diagnosis Nontuberculous Mycobacteria |
| url | http://hdl.handle.net/20.500.12123/14457 https://www.mdpi.com/2076-0817/12/4/507 https://doi.org/10.3390/pathogens12040507 |
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