Necrotic Enteritis in Young Calves
Non–enterotoxin (CPE)–producing Clostridium perfringens type A has been associated with enteritis in calves. Recent evidence has suggested that a novel toxin, named beta2 (CPB2), is implicated in the pathogenesis of this disease, although there is little evidence supporting this. In the current stud...
| Autores principales: | , , , , , |
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| Formato: | info:ar-repo/semantics/artículo |
| Lenguaje: | Inglés |
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Sage Publishing
2023
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/14430 https://journals.sagepub.com/doi/full/10.1177/104063871102300209 https://doi.org/10.1177/104063871102300209 |
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| author | Morris, Winston Eduardo Venzano, Agustin Jose Elizondo, Ana Maria Vilte, Daniel Alejandro Mercado, Elsa Cristina Fernandez Miyakawa, Mariano Enrique |
| author_browse | Elizondo, Ana Maria Fernandez Miyakawa, Mariano Enrique Mercado, Elsa Cristina Morris, Winston Eduardo Venzano, Agustin Jose Vilte, Daniel Alejandro |
| author_facet | Morris, Winston Eduardo Venzano, Agustin Jose Elizondo, Ana Maria Vilte, Daniel Alejandro Mercado, Elsa Cristina Fernandez Miyakawa, Mariano Enrique |
| author_sort | Morris, Winston Eduardo |
| collection | INTA Digital |
| description | Non–enterotoxin (CPE)–producing Clostridium perfringens type A has been associated with enteritis in calves. Recent evidence has suggested that a novel toxin, named beta2 (CPB2), is implicated in the pathogenesis of this disease, although there is little evidence supporting this. In the current study, the role of C. perfringens type A in an outbreak of enteritis in calves was studied. Two 20-day-old dairy calves exhibiting apathy and reluctance to eat, with paresis of the anterior limbs, were euthanized for postmortem examination. Gross and histological changes compatible with acute enteritis, rumenitis, meningitis, and pneumonia were seen in both calves. Clostridium perfringens type A non-CPE, non-CPB2 was isolated from the abomasum and the small intestine. Escherichia coli ONT:H8 (with cdtBIII and f17 virulence genes detected by polymerase chain reaction) was also isolated from the brain, abomasum, and intestine from both calves. All the samples were negative for Salmonella spp. When the C. perfringens strain was inoculated into bovine ligated small and large intestinal loops, cell detachment, erosion, and hemorrhage of the lamina propria were observed, predominantly in the small intestine. The results suggest that non-CPE, non-CPB2 C. perfringens type A is able to induce pathologic changes in the intestine of calves, probably enhanced by other pathogens, such as some pathogenic E. coli strains. |
| format | info:ar-repo/semantics/artículo |
| id | INTA14430 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | Sage Publishing |
| publisherStr | Sage Publishing |
| record_format | dspace |
| spelling | INTA144302023-04-10T14:05:42Z Necrotic Enteritis in Young Calves Morris, Winston Eduardo Venzano, Agustin Jose Elizondo, Ana Maria Vilte, Daniel Alejandro Mercado, Elsa Cristina Fernandez Miyakawa, Mariano Enrique Ganado Bovino Ternero Enfermedades de los Animales Enterítis Clostridium perfringens Cattle Calves Animal Diseases Enteritis Non–enterotoxin (CPE)–producing Clostridium perfringens type A has been associated with enteritis in calves. Recent evidence has suggested that a novel toxin, named beta2 (CPB2), is implicated in the pathogenesis of this disease, although there is little evidence supporting this. In the current study, the role of C. perfringens type A in an outbreak of enteritis in calves was studied. Two 20-day-old dairy calves exhibiting apathy and reluctance to eat, with paresis of the anterior limbs, were euthanized for postmortem examination. Gross and histological changes compatible with acute enteritis, rumenitis, meningitis, and pneumonia were seen in both calves. Clostridium perfringens type A non-CPE, non-CPB2 was isolated from the abomasum and the small intestine. Escherichia coli ONT:H8 (with cdtBIII and f17 virulence genes detected by polymerase chain reaction) was also isolated from the brain, abomasum, and intestine from both calves. All the samples were negative for Salmonella spp. When the C. perfringens strain was inoculated into bovine ligated small and large intestinal loops, cell detachment, erosion, and hemorrhage of the lamina propria were observed, predominantly in the small intestine. The results suggest that non-CPE, non-CPB2 C. perfringens type A is able to induce pathologic changes in the intestine of calves, probably enhanced by other pathogens, such as some pathogenic E. coli strains. Instituto de Patobiología Fil: Morris, Winston Eduardo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina Fil: Venzano, Agustin Jose. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina Fil: Elizondo, Ana Maria. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina Fil: Vilte, Daniel Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina Fil: Mercado, Elsa Cristina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina Fil: Fernandez Miyakawa, Mariano Enrique. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. 2023-04-10T14:02:35Z 2023-04-10T14:02:35Z 2011-03 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/14430 https://journals.sagepub.com/doi/full/10.1177/104063871102300209 1040-6387 1943-4936 https://doi.org/10.1177/104063871102300209 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Sage Publishing Journal of Veterinary Diagnostic Investigation 23 (2) : 254-259. (March 2011) |
| spellingShingle | Ganado Bovino Ternero Enfermedades de los Animales Enterítis Clostridium perfringens Cattle Calves Animal Diseases Enteritis Morris, Winston Eduardo Venzano, Agustin Jose Elizondo, Ana Maria Vilte, Daniel Alejandro Mercado, Elsa Cristina Fernandez Miyakawa, Mariano Enrique Necrotic Enteritis in Young Calves |
| title | Necrotic Enteritis in Young Calves |
| title_full | Necrotic Enteritis in Young Calves |
| title_fullStr | Necrotic Enteritis in Young Calves |
| title_full_unstemmed | Necrotic Enteritis in Young Calves |
| title_short | Necrotic Enteritis in Young Calves |
| title_sort | necrotic enteritis in young calves |
| topic | Ganado Bovino Ternero Enfermedades de los Animales Enterítis Clostridium perfringens Cattle Calves Animal Diseases Enteritis |
| url | http://hdl.handle.net/20.500.12123/14430 https://journals.sagepub.com/doi/full/10.1177/104063871102300209 https://doi.org/10.1177/104063871102300209 |
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