Variation in the VP1 Gene of Foot-And-Mouth Disease Virus Serotype a Associated with Epidemiological Characteristics of Outbreaks in the 2001 Epizootic in Argentina
A mixed binomial Bayesian regression model was used to quantify the relation between nucleotide differences in the VP1 gene of Foot-and-mouth disease virus (FMDV) serotype A, and epidemiologic characteristics of the outbreaks from which the viruses were obtained between January and December 2001 in...
| Main Authors: | , , , |
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| Format: | Artículo |
| Language: | Inglés |
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Sage Publishing
2023
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.12123/14428 https://journals.sagepub.com/doi/full/10.1177/104063870802000404 https://doi.org/10.1177/104063870802000404 |
| _version_ | 1855485360170074112 |
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| author | Pérez, Andrés M. Konig, Guido Alberto Spath, Ernesto Juan Thurmond, Mark C. |
| author_browse | Konig, Guido Alberto Pérez, Andrés M. Spath, Ernesto Juan Thurmond, Mark C. |
| author_facet | Pérez, Andrés M. Konig, Guido Alberto Spath, Ernesto Juan Thurmond, Mark C. |
| author_sort | Pérez, Andrés M. |
| collection | INTA Digital |
| description | A mixed binomial Bayesian regression model was used to quantify the relation between nucleotide differences in the VP1 gene of Foot-and-mouth disease virus (FMDV) serotype A, and epidemiologic characteristics of the outbreaks from which the viruses were obtained between January and December 2001 in Argentina. An increase in the probability of different nucleotides between isolates was associated with a longer time between isolation dates, a greater distance between isolation locations, an increase in the difference between attack rates, and an increase in the difference in outbreak durations. The farther apart the outbreak herds were in the southerly and easterly directions, the greater the difference in nucleotide changes. The model accurately predicted genetic distances of isolates obtained in 2001 compared with a 2002 isolate (P < 0.01), which suggested that the predictive modeling approach applied in the present study may be useful in understanding the epidemiology of evolution of FMDV and in forensic analysis of disease epidemics. |
| format | Artículo |
| id | INTA14428 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | Sage Publishing |
| publisherStr | Sage Publishing |
| record_format | dspace |
| spelling | INTA144282023-04-10T13:18:04Z Variation in the VP1 Gene of Foot-And-Mouth Disease Virus Serotype a Associated with Epidemiological Characteristics of Outbreaks in the 2001 Epizootic in Argentina Pérez, Andrés M. Konig, Guido Alberto Spath, Ernesto Juan Thurmond, Mark C. Virus Fiebre Aftosa Fiebre Aftosa Variación Genética Factores de Riesgo Argentina Epidemiología Aphthovirus Foot-and-mouth Disease Genetic Variation Risk Factors Epidemiology A mixed binomial Bayesian regression model was used to quantify the relation between nucleotide differences in the VP1 gene of Foot-and-mouth disease virus (FMDV) serotype A, and epidemiologic characteristics of the outbreaks from which the viruses were obtained between January and December 2001 in Argentina. An increase in the probability of different nucleotides between isolates was associated with a longer time between isolation dates, a greater distance between isolation locations, an increase in the difference between attack rates, and an increase in the difference in outbreak durations. The farther apart the outbreak herds were in the southerly and easterly directions, the greater the difference in nucleotide changes. The model accurately predicted genetic distances of isolates obtained in 2001 compared with a 2002 isolate (P < 0.01), which suggested that the predictive modeling approach applied in the present study may be useful in understanding the epidemiology of evolution of FMDV and in forensic analysis of disease epidemics. Instituto de Biotecnología Fil: Perez, Andrés M. University of California, Davis. School of Veterinary Medicine. Department of Medicine and Epidemiology. Center for Animal Disease Modeling and Surveillance; Estados Unidos Fil: Perez, Andrés M. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Konig, Guido Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina Fil: Konig, Guido Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Spath, Ernesto Juan. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina Fil: Thurmond, Mark C. University of California, Davis. School of Veterinary Medicine. Department of Medicine and Epidemiology. Center for Animal Disease Modeling and Surveillance; Estados Unidos 2023-04-10T13:14:57Z 2023-04-10T13:14:57Z 2008 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/14428 https://journals.sagepub.com/doi/full/10.1177/104063870802000404 1040-6387 1943-4936 https://doi.org/10.1177/104063870802000404 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Argentina .......... (nation) (World, South America) 7006477 Sage Publishing Journal of Veterinary Diagnostic Investigation 20 (4) : 433-439. (July 2008) |
| spellingShingle | Virus Fiebre Aftosa Fiebre Aftosa Variación Genética Factores de Riesgo Argentina Epidemiología Aphthovirus Foot-and-mouth Disease Genetic Variation Risk Factors Epidemiology Pérez, Andrés M. Konig, Guido Alberto Spath, Ernesto Juan Thurmond, Mark C. Variation in the VP1 Gene of Foot-And-Mouth Disease Virus Serotype a Associated with Epidemiological Characteristics of Outbreaks in the 2001 Epizootic in Argentina |
| title | Variation in the VP1 Gene of Foot-And-Mouth Disease Virus Serotype a Associated with Epidemiological Characteristics of Outbreaks in the 2001 Epizootic in Argentina |
| title_full | Variation in the VP1 Gene of Foot-And-Mouth Disease Virus Serotype a Associated with Epidemiological Characteristics of Outbreaks in the 2001 Epizootic in Argentina |
| title_fullStr | Variation in the VP1 Gene of Foot-And-Mouth Disease Virus Serotype a Associated with Epidemiological Characteristics of Outbreaks in the 2001 Epizootic in Argentina |
| title_full_unstemmed | Variation in the VP1 Gene of Foot-And-Mouth Disease Virus Serotype a Associated with Epidemiological Characteristics of Outbreaks in the 2001 Epizootic in Argentina |
| title_short | Variation in the VP1 Gene of Foot-And-Mouth Disease Virus Serotype a Associated with Epidemiological Characteristics of Outbreaks in the 2001 Epizootic in Argentina |
| title_sort | variation in the vp1 gene of foot and mouth disease virus serotype a associated with epidemiological characteristics of outbreaks in the 2001 epizootic in argentina |
| topic | Virus Fiebre Aftosa Fiebre Aftosa Variación Genética Factores de Riesgo Argentina Epidemiología Aphthovirus Foot-and-mouth Disease Genetic Variation Risk Factors Epidemiology |
| url | http://hdl.handle.net/20.500.12123/14428 https://journals.sagepub.com/doi/full/10.1177/104063870802000404 https://doi.org/10.1177/104063870802000404 |
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