Biological evaluation of Valeriana extracts from Argentina with potent cholinesterase inhibition for the treatment of neurodegenerative disorders and their comorbidities the case of Valeriana carnosa Sm. (Caprifoliaceae) studied in mice
Alzheimer’s disease (AD) is a neurodegenerative disorder whose pathophysiology in cludes the abnormal accumulation of proteins (e.g., β-amyloid), oxidative stress, and alterations in neurotransmitter levels, mainly acetylcholine. Here we present a comparative study of the ef fect of extracts obtaine...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | info:ar-repo/semantics/artículo |
| Language: | Inglés |
| Published: |
MDPI
2023
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.12123/14322 https://www.mdpi.com/1424-8247/16/1/129 https://doi.org/10.3390/ph16010129 |
| _version_ | 1855037097105162240 |
|---|---|
| author | Marcucci, Carolina Rademacher, Marina Kamecki, Fabiola Pastore, Velentina Bach, Hernán Gerónimo Ricco, Rafael Alejandro Wagner, Marcelo Luis Knez, Damijan Gobec, Stanislav Colettis, Natalia Mander, Mariel |
| author_browse | Bach, Hernán Gerónimo Colettis, Natalia Gobec, Stanislav Kamecki, Fabiola Knez, Damijan Mander, Mariel Marcucci, Carolina Pastore, Velentina Rademacher, Marina Ricco, Rafael Alejandro Wagner, Marcelo Luis |
| author_facet | Marcucci, Carolina Rademacher, Marina Kamecki, Fabiola Pastore, Velentina Bach, Hernán Gerónimo Ricco, Rafael Alejandro Wagner, Marcelo Luis Knez, Damijan Gobec, Stanislav Colettis, Natalia Mander, Mariel |
| author_sort | Marcucci, Carolina |
| collection | INTA Digital |
| description | Alzheimer’s disease (AD) is a neurodegenerative disorder whose pathophysiology in cludes the abnormal accumulation of proteins (e.g., β-amyloid), oxidative stress, and alterations in neurotransmitter levels, mainly acetylcholine. Here we present a comparative study of the ef fect of extracts obtained from endemic Argentinian species of valerians, namely V. carnosa Sm., V. clarionifolia Phil. and V. macrorhiza Poepp. ex DC from Patagonia and V. ferax (Griseb.) Höck and V. effusa Griseb., on different AD-related biological targets. Of these anxiolytic, sedative and sleep-inducing valerians, V. carnosa proved the most promising and was assayed in vivo. All valerians inhibited acetylcholinesterase (IC50 between 1.08–12.69 mg/mL) and butyrylcholinesterase (IC50 between 0.0019–1.46 mg/mL). They also inhibited the aggregation of β-amyloid peptide, were able to chelate Fe2+ ions, and exhibited a direct relationship between antioxidant capacity and phenolic content. Moreover, V. carnosa was able to inhibit human monoamine oxidase A (IC50: 0.286 mg/mL (0.213–0.384)). A daily intake of aqueous V. carnosa extract by male Swiss mice (50 and 150 mg/kg/day) resulted in anxiolytic and antidepressant-like behavior and improved spatial memory. In addition, decreased AChE activity and oxidative stress markers were observed in treated mouse brains. Our studies contribute to the development of indigenous herbal medicines as therapeutic agents for AD. |
| format | info:ar-repo/semantics/artículo |
| id | INTA14322 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI |
| publisherStr | MDPI |
| record_format | dspace |
| spelling | INTA143222023-03-23T15:52:14Z Biological evaluation of Valeriana extracts from Argentina with potent cholinesterase inhibition for the treatment of neurodegenerative disorders and their comorbidities the case of Valeriana carnosa Sm. (Caprifoliaceae) studied in mice Marcucci, Carolina Rademacher, Marina Kamecki, Fabiola Pastore, Velentina Bach, Hernán Gerónimo Ricco, Rafael Alejandro Wagner, Marcelo Luis Knez, Damijan Gobec, Stanislav Colettis, Natalia Mander, Mariel Medicinal Plants Acetylcholinesterase Antioxidants Monoamine Oxidase Memory Valeriana Plantas Medicinales Acetilcolinesterasa Antioxidantes Monoamina Oxidasa Memoria Argentina Alzheimer´s Disease B Amyloid Aggregation Antidepressant Enfermedad de Alzheimer Agregación de Amiloide B Antidepresivo Alzheimer’s disease (AD) is a neurodegenerative disorder whose pathophysiology in cludes the abnormal accumulation of proteins (e.g., β-amyloid), oxidative stress, and alterations in neurotransmitter levels, mainly acetylcholine. Here we present a comparative study of the ef fect of extracts obtained from endemic Argentinian species of valerians, namely V. carnosa Sm., V. clarionifolia Phil. and V. macrorhiza Poepp. ex DC from Patagonia and V. ferax (Griseb.) Höck and V. effusa Griseb., on different AD-related biological targets. Of these anxiolytic, sedative and sleep-inducing valerians, V. carnosa proved the most promising and was assayed in vivo. All valerians inhibited acetylcholinesterase (IC50 between 1.08–12.69 mg/mL) and butyrylcholinesterase (IC50 between 0.0019–1.46 mg/mL). They also inhibited the aggregation of β-amyloid peptide, were able to chelate Fe2+ ions, and exhibited a direct relationship between antioxidant capacity and phenolic content. Moreover, V. carnosa was able to inhibit human monoamine oxidase A (IC50: 0.286 mg/mL (0.213–0.384)). A daily intake of aqueous V. carnosa extract by male Swiss mice (50 and 150 mg/kg/day) resulted in anxiolytic and antidepressant-like behavior and improved spatial memory. In addition, decreased AChE activity and oxidative stress markers were observed in treated mouse brains. Our studies contribute to the development of indigenous herbal medicines as therapeutic agents for AD. Instituto de Recursos Biológicos Fil: Marcucci, Carolina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini; Argentina Fil: Rademacher, Marina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini; Argentina Fil: Kamecki, Fabiola. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini; Argentina Fil: Pastore, Valentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini; Argentina Fil: Bach, Hernán Gerónimo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Recursos Biológicos; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Farmacobotánica; Argentina Fil: Ricco, Rafael. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Farmabotánica; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Tecnología Farmaceutica y Biofarmacia; Argentina Fil: Wagner, Marcelo L. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Farmacobotánica; Argentina Fil: Knez, Damijan. University of Ljubljana; Faculty of Pharmacy, Slovenia. Fil: Gobec, Stanislav. University of Ljubljana; Faculty of Pharmacy, Slovenia. Fil: Colettis, Natalia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini; Argentina Fil: Marder, Mariel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro C. Paladini; Argentina 2023-03-23T15:21:22Z 2023-03-23T15:21:22Z 2023-01-01 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/14322 https://www.mdpi.com/1424-8247/16/1/129 1424-8247 https://doi.org/10.3390/ph16010129 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf MDPI Pharmaceuticals 16 (1) : 129 (January 2023) |
| spellingShingle | Medicinal Plants Acetylcholinesterase Antioxidants Monoamine Oxidase Memory Valeriana Plantas Medicinales Acetilcolinesterasa Antioxidantes Monoamina Oxidasa Memoria Argentina Alzheimer´s Disease B Amyloid Aggregation Antidepressant Enfermedad de Alzheimer Agregación de Amiloide B Antidepresivo Marcucci, Carolina Rademacher, Marina Kamecki, Fabiola Pastore, Velentina Bach, Hernán Gerónimo Ricco, Rafael Alejandro Wagner, Marcelo Luis Knez, Damijan Gobec, Stanislav Colettis, Natalia Mander, Mariel Biological evaluation of Valeriana extracts from Argentina with potent cholinesterase inhibition for the treatment of neurodegenerative disorders and their comorbidities the case of Valeriana carnosa Sm. (Caprifoliaceae) studied in mice |
| title | Biological evaluation of Valeriana extracts from Argentina with potent cholinesterase inhibition for the treatment of neurodegenerative disorders and their comorbidities the case of Valeriana carnosa Sm. (Caprifoliaceae) studied in mice |
| title_full | Biological evaluation of Valeriana extracts from Argentina with potent cholinesterase inhibition for the treatment of neurodegenerative disorders and their comorbidities the case of Valeriana carnosa Sm. (Caprifoliaceae) studied in mice |
| title_fullStr | Biological evaluation of Valeriana extracts from Argentina with potent cholinesterase inhibition for the treatment of neurodegenerative disorders and their comorbidities the case of Valeriana carnosa Sm. (Caprifoliaceae) studied in mice |
| title_full_unstemmed | Biological evaluation of Valeriana extracts from Argentina with potent cholinesterase inhibition for the treatment of neurodegenerative disorders and their comorbidities the case of Valeriana carnosa Sm. (Caprifoliaceae) studied in mice |
| title_short | Biological evaluation of Valeriana extracts from Argentina with potent cholinesterase inhibition for the treatment of neurodegenerative disorders and their comorbidities the case of Valeriana carnosa Sm. (Caprifoliaceae) studied in mice |
| title_sort | biological evaluation of valeriana extracts from argentina with potent cholinesterase inhibition for the treatment of neurodegenerative disorders and their comorbidities the case of valeriana carnosa sm caprifoliaceae studied in mice |
| topic | Medicinal Plants Acetylcholinesterase Antioxidants Monoamine Oxidase Memory Valeriana Plantas Medicinales Acetilcolinesterasa Antioxidantes Monoamina Oxidasa Memoria Argentina Alzheimer´s Disease B Amyloid Aggregation Antidepressant Enfermedad de Alzheimer Agregación de Amiloide B Antidepresivo |
| url | http://hdl.handle.net/20.500.12123/14322 https://www.mdpi.com/1424-8247/16/1/129 https://doi.org/10.3390/ph16010129 |
| work_keys_str_mv | AT marcuccicarolina biologicalevaluationofvalerianaextractsfromargentinawithpotentcholinesteraseinhibitionforthetreatmentofneurodegenerativedisordersandtheircomorbiditiesthecaseofvalerianacarnosasmcaprifoliaceaestudiedinmice AT rademachermarina biologicalevaluationofvalerianaextractsfromargentinawithpotentcholinesteraseinhibitionforthetreatmentofneurodegenerativedisordersandtheircomorbiditiesthecaseofvalerianacarnosasmcaprifoliaceaestudiedinmice AT kameckifabiola biologicalevaluationofvalerianaextractsfromargentinawithpotentcholinesteraseinhibitionforthetreatmentofneurodegenerativedisordersandtheircomorbiditiesthecaseofvalerianacarnosasmcaprifoliaceaestudiedinmice AT pastorevelentina biologicalevaluationofvalerianaextractsfromargentinawithpotentcholinesteraseinhibitionforthetreatmentofneurodegenerativedisordersandtheircomorbiditiesthecaseofvalerianacarnosasmcaprifoliaceaestudiedinmice AT bachhernangeronimo biologicalevaluationofvalerianaextractsfromargentinawithpotentcholinesteraseinhibitionforthetreatmentofneurodegenerativedisordersandtheircomorbiditiesthecaseofvalerianacarnosasmcaprifoliaceaestudiedinmice AT riccorafaelalejandro biologicalevaluationofvalerianaextractsfromargentinawithpotentcholinesteraseinhibitionforthetreatmentofneurodegenerativedisordersandtheircomorbiditiesthecaseofvalerianacarnosasmcaprifoliaceaestudiedinmice AT wagnermarceloluis biologicalevaluationofvalerianaextractsfromargentinawithpotentcholinesteraseinhibitionforthetreatmentofneurodegenerativedisordersandtheircomorbiditiesthecaseofvalerianacarnosasmcaprifoliaceaestudiedinmice AT knezdamijan biologicalevaluationofvalerianaextractsfromargentinawithpotentcholinesteraseinhibitionforthetreatmentofneurodegenerativedisordersandtheircomorbiditiesthecaseofvalerianacarnosasmcaprifoliaceaestudiedinmice AT gobecstanislav biologicalevaluationofvalerianaextractsfromargentinawithpotentcholinesteraseinhibitionforthetreatmentofneurodegenerativedisordersandtheircomorbiditiesthecaseofvalerianacarnosasmcaprifoliaceaestudiedinmice AT colettisnatalia biologicalevaluationofvalerianaextractsfromargentinawithpotentcholinesteraseinhibitionforthetreatmentofneurodegenerativedisordersandtheircomorbiditiesthecaseofvalerianacarnosasmcaprifoliaceaestudiedinmice AT mandermariel biologicalevaluationofvalerianaextractsfromargentinawithpotentcholinesteraseinhibitionforthetreatmentofneurodegenerativedisordersandtheircomorbiditiesthecaseofvalerianacarnosasmcaprifoliaceaestudiedinmice |