Microscopic lesions and modulation of gene expression in cervical medulla during BoAHV-1and BoAHV-5 infection: A mini-review
Bovine herpesvirus (BoAHV) types 1 and 5 are closely-related neurotropic alpha-herpesviruses. BoAHV-1 generally causes respiratory and genital disease but can occasionally cause encephalitis. BoAHV-5 is the causative agent of non suppurative meningoencephalitis in calves. During neuroinvasion, both...
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| Format: | Artículo |
| Language: | Inglés |
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Elsevier
2023
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| Online Access: | http://hdl.handle.net/20.500.12123/14105 https://www.sciencedirect.com/science/article/pii/S0034528823000486 https://doi.org/10.1016/j.rvsc.2023.02.002 |
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| author | Marin, Maia Solange Rensetti, D. Burucúa, Mercedes María Rosales, J. Martinez Cuesta, Nicolás Pérez, S. |
| author_browse | Burucúa, Mercedes María Marin, Maia Solange Martinez Cuesta, Nicolás Pérez, S. Rensetti, D. Rosales, J. |
| author_facet | Marin, Maia Solange Rensetti, D. Burucúa, Mercedes María Rosales, J. Martinez Cuesta, Nicolás Pérez, S. |
| author_sort | Marin, Maia Solange |
| collection | INTA Digital |
| description | Bovine herpesvirus (BoAHV) types 1 and 5 are closely-related neurotropic alpha-herpesviruses. BoAHV-1 generally causes respiratory and genital disease but can occasionally cause encephalitis. BoAHV-5 is the causative agent of non suppurative meningoencephalitis in calves. During neuroinvasion, both viruses reach the central and peripheral nervous system. While brain alterations are well-described, the changes that occur in the medulla have not been fully detailed. In this work, we integrated and analyzed the virological findings, the microscopic lesions and the changes that occur in the expression of genes related to the innate immunity, cell cycle and apoptosis in the cervical medulla of calves experimentally-infected with BoAHV-1 and BoAHV-5. This will contribute to the understanding of the differential neuropathogenesis of these alpha-herpesviruses of cattle. |
| format | Artículo |
| id | INTA14105 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | INTA141052023-03-01T10:02:46Z Microscopic lesions and modulation of gene expression in cervical medulla during BoAHV-1and BoAHV-5 infection: A mini-review Marin, Maia Solange Rensetti, D. Burucúa, Mercedes María Rosales, J. Martinez Cuesta, Nicolás Pérez, S. Médula Herpes Virus Bovino Expresión Génica Infección Pith Bovine Herpesvirus Gene Expression Infection Bovine herpesvirus (BoAHV) types 1 and 5 are closely-related neurotropic alpha-herpesviruses. BoAHV-1 generally causes respiratory and genital disease but can occasionally cause encephalitis. BoAHV-5 is the causative agent of non suppurative meningoencephalitis in calves. During neuroinvasion, both viruses reach the central and peripheral nervous system. While brain alterations are well-described, the changes that occur in the medulla have not been fully detailed. In this work, we integrated and analyzed the virological findings, the microscopic lesions and the changes that occur in the expression of genes related to the innate immunity, cell cycle and apoptosis in the cervical medulla of calves experimentally-infected with BoAHV-1 and BoAHV-5. This will contribute to the understanding of the differential neuropathogenesis of these alpha-herpesviruses of cattle. EEA Balcarce Fil: Marin, Maia Solange. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Fil: Rensetti, D. Center for Women's Infectious Disease Research-Washington University School of Medicine. Department of Molecular Microbiology; Estados Unidos. Fil: Burucúa, María Mercedes. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Fil: Rosales, J.J. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Centro de Investigación Veterinaria de Tandil; Argentina. Fil: Martínez Cuesta, L. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Centro de Investigación Veterinaria de Tandil; Argentina. Fil: Pérez, S. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Centro de Investigación Veterinaria de Tandil; Argentina. 2023-03-01T09:59:05Z 2023-03-01T09:59:05Z 2023-03 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/14105 https://www.sciencedirect.com/science/article/pii/S0034528823000486 0034-5288 (print) 1532-2661 (online) https://doi.org/10.1016/j.rvsc.2023.02.002 eng info:eu-repo/semantics/restrictedAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Elsevier Research in Veterinary Science 156 : 81-87 (March 2023) |
| spellingShingle | Médula Herpes Virus Bovino Expresión Génica Infección Pith Bovine Herpesvirus Gene Expression Infection Marin, Maia Solange Rensetti, D. Burucúa, Mercedes María Rosales, J. Martinez Cuesta, Nicolás Pérez, S. Microscopic lesions and modulation of gene expression in cervical medulla during BoAHV-1and BoAHV-5 infection: A mini-review |
| title | Microscopic lesions and modulation of gene expression in cervical medulla during BoAHV-1and BoAHV-5 infection: A mini-review |
| title_full | Microscopic lesions and modulation of gene expression in cervical medulla during BoAHV-1and BoAHV-5 infection: A mini-review |
| title_fullStr | Microscopic lesions and modulation of gene expression in cervical medulla during BoAHV-1and BoAHV-5 infection: A mini-review |
| title_full_unstemmed | Microscopic lesions and modulation of gene expression in cervical medulla during BoAHV-1and BoAHV-5 infection: A mini-review |
| title_short | Microscopic lesions and modulation of gene expression in cervical medulla during BoAHV-1and BoAHV-5 infection: A mini-review |
| title_sort | microscopic lesions and modulation of gene expression in cervical medulla during boahv 1and boahv 5 infection a mini review |
| topic | Médula Herpes Virus Bovino Expresión Génica Infección Pith Bovine Herpesvirus Gene Expression Infection |
| url | http://hdl.handle.net/20.500.12123/14105 https://www.sciencedirect.com/science/article/pii/S0034528823000486 https://doi.org/10.1016/j.rvsc.2023.02.002 |
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