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Microscopic lesions and modulation of gene expression in cervical medulla during BoAHV-1and BoAHV-5 infection: A mini-review

Bovine herpesvirus (BoAHV) types 1 and 5 are closely-related neurotropic alpha-herpesviruses. BoAHV-1 generally causes respiratory and genital disease but can occasionally cause encephalitis. BoAHV-5 is the causative agent of non suppurative meningoencephalitis in calves. During neuroinvasion, both...

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Main Authors: Marin, Maia Solange, Rensetti, D., Burucúa, Mercedes María, Rosales, J., Martinez Cuesta, Nicolás, Pérez, S.
Format: Artículo
Language:Inglés
Published: Elsevier 2023
Subjects:
Médula
Herpes Virus Bovino
Expresión Génica
Infección
Pith
Bovine Herpesvirus
Gene Expression
Infection
Online Access:http://hdl.handle.net/20.500.12123/14105
https://www.sciencedirect.com/science/article/pii/S0034528823000486
https://doi.org/10.1016/j.rvsc.2023.02.002
Summary:Bovine herpesvirus (BoAHV) types 1 and 5 are closely-related neurotropic alpha-herpesviruses. BoAHV-1 generally causes respiratory and genital disease but can occasionally cause encephalitis. BoAHV-5 is the causative agent of non suppurative meningoencephalitis in calves. During neuroinvasion, both viruses reach the central and peripheral nervous system. While brain alterations are well-described, the changes that occur in the medulla have not been fully detailed. In this work, we integrated and analyzed the virological findings, the microscopic lesions and the changes that occur in the expression of genes related to the innate immunity, cell cycle and apoptosis in the cervical medulla of calves experimentally-infected with BoAHV-1 and BoAHV-5. This will contribute to the understanding of the differential neuropathogenesis of these alpha-herpesviruses of cattle.

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