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Genetic diversity of GH1 and LEP genes in Argentine llama [Lama glama] populations

Compared to other domestic species, little is known about variability of genes related to energetic metabolism and growth in camelids. Here, we have analyzed leptin (LEP) and growth hormone (GH1) genes and characterized their variability in three local llama (Lama glama) populations from the Argenti...

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Main Authors: Daverio, Maria Silvana, Lorenzo, Yanina, Rigalt, Francisco Antonio, Vidal Rioja, Lidia Beatriz, Di Rocco, Florencia
Format: info:ar-repo/semantics/artículo
Language:Inglés
Published: 2017
Subjects:
Llama
Genes
Polimorfismo Genético
Variación Genética
Genetic Polymorphism
Genetic Variation
Lama Glama
Gen GH1
Gen LEP
Growth Related Genes
Online Access:http://hdl.handle.net/20.500.12123/1352
http://www.sciencedirect.com/science/article/pii/S0921448814000972
https://doi.org/10.1016/j.smallrumres.2014.03.014
Summary:Compared to other domestic species, little is known about variability of genes related to energetic metabolism and growth in camelids. Here, we have analyzed leptin (LEP) and growth hormone (GH1) genes and characterized their variability in three local llama (Lama glama) populations from the Argentine Northwest. Eleven novel SNPs and one indel were identified in the Lep gene. In total, eight haplotypes were found for LEP and seven for GH1. Although geographical origin clustering was not observed, SNP and haplotype frequencies varied significantly among populations. Based on variation of both loci, we detected significant genetic differentiation measured through Fst values. Network analysis of LEP gene supported the well-documented history of hybridization in camelids previously identified by mtDNA analysis.

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