A South American Mouse Morbillivirus Provides Insight into a Clade of Rodent-Borne Morbilliviruses
Morbilliviruses are negative-sense single-stranded monosegmented RNA viruses in the family Paramyxoviridae (order Mononegavirales). Morbilliviruses infect diverse mammals including humans, dogs, cats, small ruminants, seals, and cetaceans, which serve as natural hosts. Here, I report the identificat...
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| Format: | info:ar-repo/semantics/artículo |
| Language: | Inglés |
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MDPI
2022
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| Online Access: | http://hdl.handle.net/20.500.12123/13461 https://www.mdpi.com/1999-4915/14/11/2403 https://doi.org/10.3390/v14112403 |
| _version_ | 1855036946503434240 |
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| author | Debat, Humberto Julio |
| author_browse | Debat, Humberto Julio |
| author_facet | Debat, Humberto Julio |
| author_sort | Debat, Humberto Julio |
| collection | INTA Digital |
| description | Morbilliviruses are negative-sense single-stranded monosegmented RNA viruses in the family Paramyxoviridae (order Mononegavirales). Morbilliviruses infect diverse mammals including humans, dogs, cats, small ruminants, seals, and cetaceans, which serve as natural hosts. Here, I report the identification and characterization of novel viruses detected in public RNAseq datasets of South American long-haired and olive field mice. The divergent viruses dubbed Ratón oliváceo morbillivirus (RoMV) detected in renal samples from mice collected from Chile and Argentina are characterized by an unusually large genome including long intergenic regions and the presence of an accessory protein between the F and H genes redounding in a genome architecture consisting in 3′-N-P/V/C-M-F-hp-H-L-5′. Structural and functional annotation, genetic distance, and evolutionary insights suggest that RoMV is a member of a novel species within genus Morbillivirus tentatively named as South American mouse morbillivirus. Phylogenetic analysis suggests that this mouse morbillivirus is closely related to and clusters into a monophyletic group of novel rodent-borne morbilliviruses. This subclade of divergent viruses expands the host range, redefines the genomic organization and provides insights on the evolutionary history of genus Morbillivirus. |
| format | info:ar-repo/semantics/artículo |
| id | INTA13461 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI |
| publisherStr | MDPI |
| record_format | dspace |
| spelling | INTA134612022-11-28T11:38:13Z A South American Mouse Morbillivirus Provides Insight into a Clade of Rodent-Borne Morbilliviruses Debat, Humberto Julio Morbillivirus Roedores Rodents Virus Discovery Abrothrix Ratón Oliváceo Mouse Morbillivirus Morbilliviruses are negative-sense single-stranded monosegmented RNA viruses in the family Paramyxoviridae (order Mononegavirales). Morbilliviruses infect diverse mammals including humans, dogs, cats, small ruminants, seals, and cetaceans, which serve as natural hosts. Here, I report the identification and characterization of novel viruses detected in public RNAseq datasets of South American long-haired and olive field mice. The divergent viruses dubbed Ratón oliváceo morbillivirus (RoMV) detected in renal samples from mice collected from Chile and Argentina are characterized by an unusually large genome including long intergenic regions and the presence of an accessory protein between the F and H genes redounding in a genome architecture consisting in 3′-N-P/V/C-M-F-hp-H-L-5′. Structural and functional annotation, genetic distance, and evolutionary insights suggest that RoMV is a member of a novel species within genus Morbillivirus tentatively named as South American mouse morbillivirus. Phylogenetic analysis suggests that this mouse morbillivirus is closely related to and clusters into a monophyletic group of novel rodent-borne morbilliviruses. This subclade of divergent viruses expands the host range, redefines the genomic organization and provides insights on the evolutionary history of genus Morbillivirus. Instituto de Patología Vegetal Fil: Debat, Humberto Julio. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patología Vegetal; Argentina Fil: Debat, Humberto Julio. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Fitopatología y Modelización Agrícola (UFyMA); Argentina 2022-11-28T11:30:10Z 2022-11-28T11:30:10Z 2022-10-29 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/13461 https://www.mdpi.com/1999-4915/14/11/2403 1999-4915 (online) https://doi.org/10.3390/v14112403 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf MDPI Viruses 14 (11) : 2403 (November 2022) |
| spellingShingle | Morbillivirus Roedores Rodents Virus Discovery Abrothrix Ratón Oliváceo Mouse Morbillivirus Debat, Humberto Julio A South American Mouse Morbillivirus Provides Insight into a Clade of Rodent-Borne Morbilliviruses |
| title | A South American Mouse Morbillivirus Provides Insight into a Clade of Rodent-Borne Morbilliviruses |
| title_full | A South American Mouse Morbillivirus Provides Insight into a Clade of Rodent-Borne Morbilliviruses |
| title_fullStr | A South American Mouse Morbillivirus Provides Insight into a Clade of Rodent-Borne Morbilliviruses |
| title_full_unstemmed | A South American Mouse Morbillivirus Provides Insight into a Clade of Rodent-Borne Morbilliviruses |
| title_short | A South American Mouse Morbillivirus Provides Insight into a Clade of Rodent-Borne Morbilliviruses |
| title_sort | south american mouse morbillivirus provides insight into a clade of rodent borne morbilliviruses |
| topic | Morbillivirus Roedores Rodents Virus Discovery Abrothrix Ratón Oliváceo Mouse Morbillivirus |
| url | http://hdl.handle.net/20.500.12123/13461 https://www.mdpi.com/1999-4915/14/11/2403 https://doi.org/10.3390/v14112403 |
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