Quantitative exposure assessment and risk characterization for fipronil residues in laying hen eggs
Poultry production is linked to veterinary drug use to treat diseases. Few ectoparasitic compounds are approved for poultry. Fipronil is a pesticide widely used in agriculture. It is also a drug authorized to control ectoparasites in small animals and, in some countries, in cattle. There has been ev...
| Autores principales: | , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
| Publicado: |
Wiley
2022
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/12921 https://ift.onlinelibrary.wiley.com/doi/full/10.1111/1750-3841.16161 https://doi.org/10.1111/1750-3841.16161 |
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| author | Canton, Lucila Signorini Porchiett, Marcelo Lisandro Canton, Candela Dominguez, Paula Farias, Cristina Alvarez, Luis Lanusse, Carlos Moreno, Laura |
| author_browse | Alvarez, Luis Canton, Candela Canton, Lucila Dominguez, Paula Farias, Cristina Lanusse, Carlos Moreno, Laura Signorini Porchiett, Marcelo Lisandro |
| author_facet | Canton, Lucila Signorini Porchiett, Marcelo Lisandro Canton, Candela Dominguez, Paula Farias, Cristina Alvarez, Luis Lanusse, Carlos Moreno, Laura |
| author_sort | Canton, Lucila |
| collection | INTA Digital |
| description | Poultry production is linked to veterinary drug use to treat diseases. Few ectoparasitic compounds are approved for poultry. Fipronil is a pesticide widely used in agriculture. It is also a drug authorized to control ectoparasites in small animals and, in some countries, in cattle. There has been evidence of fipronil extra-label use in laying hens, mainly to control the red mite Dermanyssus gallinae. Fipronil's popularity is due to its high toxicity to invertebrates. It could be metabolized to more toxic metabolites that potentially damage human health. In the present study, we carry out a quantitative exposure assessment and risk characterization for fipronil residues in laying hen eggs for local consumption in five cities of Buenos Aires province in Argentina, namely, Azul, Balcarce, Juarez, Chaves, and Tandil. Consumption surveys and egg sampling were conducted for three summer periods. Eggs were analyzed by UFLC-MS-MS. Fipronil prevalence, residue concentrations, residue stability to cooking methods, egg consumption, among the most important variables were modeled. The results indicated that 20.7% of samples contained fipronil residues. The highest residue was fipronil sulfone metabolite. Fipronil concentrations quantified ranged between 10 and 2510 ppb (median value = 150 ppb). When eggs were cooked, fipronil residues were stable. The exposure assessment and risk characterization revealed that the highest probability of consuming eggs with fipronil residues above the admissible limits was for young adults (20.8%), followed by babies (16.9%), young children (16.4%), children (13.4%), teenagers (10.3%), older adults (9.41%), and adults (8.65%). These results suggest an unacceptable risk associated with egg consumption with fipronil residues for all age groups. |
| format | Artículo |
| id | INTA12921 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | Wiley |
| publisherStr | Wiley |
| record_format | dspace |
| spelling | INTA129212022-09-21T12:03:58Z Quantitative exposure assessment and risk characterization for fipronil residues in laying hen eggs Canton, Lucila Signorini Porchiett, Marcelo Lisandro Canton, Candela Dominguez, Paula Farias, Cristina Alvarez, Luis Lanusse, Carlos Moreno, Laura Eggs Fipronil Hens Layer Chickens Huevos Gallinas Gallina Ponedora Exposure Assessment Asesoramiento sobre Exposición Poultry production is linked to veterinary drug use to treat diseases. Few ectoparasitic compounds are approved for poultry. Fipronil is a pesticide widely used in agriculture. It is also a drug authorized to control ectoparasites in small animals and, in some countries, in cattle. There has been evidence of fipronil extra-label use in laying hens, mainly to control the red mite Dermanyssus gallinae. Fipronil's popularity is due to its high toxicity to invertebrates. It could be metabolized to more toxic metabolites that potentially damage human health. In the present study, we carry out a quantitative exposure assessment and risk characterization for fipronil residues in laying hen eggs for local consumption in five cities of Buenos Aires province in Argentina, namely, Azul, Balcarce, Juarez, Chaves, and Tandil. Consumption surveys and egg sampling were conducted for three summer periods. Eggs were analyzed by UFLC-MS-MS. Fipronil prevalence, residue concentrations, residue stability to cooking methods, egg consumption, among the most important variables were modeled. The results indicated that 20.7% of samples contained fipronil residues. The highest residue was fipronil sulfone metabolite. Fipronil concentrations quantified ranged between 10 and 2510 ppb (median value = 150 ppb). When eggs were cooked, fipronil residues were stable. The exposure assessment and risk characterization revealed that the highest probability of consuming eggs with fipronil residues above the admissible limits was for young adults (20.8%), followed by babies (16.9%), young children (16.4%), children (13.4%), teenagers (10.3%), older adults (9.41%), and adults (8.65%). These results suggest an unacceptable risk associated with egg consumption with fipronil residues for all age groups. EEA Rafaela Fil: Canton, Lucila. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Laboratorio de Farmacología; Argentina Fil: Canton, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación Veterinaria de Tandil (CIVETAN); Argentina Fil: Signorini, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación de la Cadena Láctea (IDICAL); Argentina Fil: Signorini, Marcelo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela. Instituto de Investigación de la Cadena Láctea (IDICAL); Argentina Fil: Canton, Candela. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Laboratorio de Farmacología; Argentina Fil: Canton, Candela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación Veterinaria de Tandil (CIVETAN); Argentina Fil: Dominguez, Paula. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Laboratorio de Farmacología; Argentina Fil: Dominguez, Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación Veterinaria de Tandil (CIVETAN); Argentina Fil: Farias, Cristina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Laboratorio de Farmacología; Argentina Fil: Farias, Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación Veterinaria de Tandil (CIVETAN); Argentina Fil: Alvarez, Luis. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Laboratorio de Farmacología; Argentina Fil: Alvarez, Luis . Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación Veterinaria de Tandil (CIVETAN); Argentina Fil: Lanusse, Carlos. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Laboratorio de Farmacología; Argentina Fil: Lanusse, Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación Veterinaria de Tandil (CIVETAN); Argentina Fil: Moreno, Laura. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil (CIVETAN). Laboratorio de Farmacología; Argentina Fil: Moreno, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación Veterinaria de Tandil (CIVETAN); Argentina Fil: Signorini, Marcelo. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Salud Pública; Argentina 2022-09-21T11:53:17Z 2022-09-21T11:53:17Z 2022-06 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/12921 https://ift.onlinelibrary.wiley.com/doi/full/10.1111/1750-3841.16161 Canton, L., Signorini, M., Canton, C., Dominguez, P., Farias, C., Alvarez, L., Lanusse, C., & Moreno, L. (2022). Quantitative exposure assessment and risk characterization for fipronil residues in laying hen eggs. Journal of Food Science, 87, 2775– 2788. https://doi.org/10.1111/1750-3841.16161 1750-3841 (online) https://doi.org/10.1111/1750-3841.16161 eng info:eu-repo/semantics/restrictedAccess application/pdf Wiley Journal of Food Science 87 (6) : 2775-2788 (June 2022) |
| spellingShingle | Eggs Fipronil Hens Layer Chickens Huevos Gallinas Gallina Ponedora Exposure Assessment Asesoramiento sobre Exposición Canton, Lucila Signorini Porchiett, Marcelo Lisandro Canton, Candela Dominguez, Paula Farias, Cristina Alvarez, Luis Lanusse, Carlos Moreno, Laura Quantitative exposure assessment and risk characterization for fipronil residues in laying hen eggs |
| title | Quantitative exposure assessment and risk characterization for fipronil residues in laying hen eggs |
| title_full | Quantitative exposure assessment and risk characterization for fipronil residues in laying hen eggs |
| title_fullStr | Quantitative exposure assessment and risk characterization for fipronil residues in laying hen eggs |
| title_full_unstemmed | Quantitative exposure assessment and risk characterization for fipronil residues in laying hen eggs |
| title_short | Quantitative exposure assessment and risk characterization for fipronil residues in laying hen eggs |
| title_sort | quantitative exposure assessment and risk characterization for fipronil residues in laying hen eggs |
| topic | Eggs Fipronil Hens Layer Chickens Huevos Gallinas Gallina Ponedora Exposure Assessment Asesoramiento sobre Exposición |
| url | http://hdl.handle.net/20.500.12123/12921 https://ift.onlinelibrary.wiley.com/doi/full/10.1111/1750-3841.16161 https://doi.org/10.1111/1750-3841.16161 |
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