Efficacy of prepartum vaccination against neonatal calf diarrhea in Nelore dams as a prevention measure
Background: Neonatal calf diarrhea (NCD) is the leading cause of calf morbidity and mortality in beef cattle. Cow’s vaccination in last stage of pregnancy is one of the most important measures to mitigate the risk of NCD outbreaks. The aim of this study was to evaluate the efficacy of prepartum sing...
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| Format: | info:ar-repo/semantics/artículo |
| Language: | Inglés |
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BioMed Central
2022
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| Online Access: | http://hdl.handle.net/20.500.12123/12708 https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-022-03391-5 https://doi.org/10.1186/s12917-022-03391-5 |
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| author | Pinheiro, Filipe Aguera Decaris, Nathália Parreño, Gladys Viviana Brandão, Paulo Eduardo Ayres, Henderson Gomes, Viviani |
| author_browse | Ayres, Henderson Brandão, Paulo Eduardo Decaris, Nathália Gomes, Viviani Parreño, Gladys Viviana Pinheiro, Filipe Aguera |
| author_facet | Pinheiro, Filipe Aguera Decaris, Nathália Parreño, Gladys Viviana Brandão, Paulo Eduardo Ayres, Henderson Gomes, Viviani |
| author_sort | Pinheiro, Filipe Aguera |
| collection | INTA Digital |
| description | Background: Neonatal calf diarrhea (NCD) is the leading cause of calf morbidity and mortality in beef cattle. Cow’s vaccination in last stage of pregnancy is one of the most important measures to mitigate the risk of NCD outbreaks. The aim of this study was to evaluate the efficacy of prepartum single dose vaccination against NCD, especially Bovine Rotavirus type A (BoRVA) and Bovine Coronavirus (BCoV), in Nelore dams and offspring. A total of 117 pregnant cows (n = 81) and heifers (n = 36) were distributed in two groups, vaccinated (VAC: cows = 40; heifers = 19) and nonvaccinated (NVAC: cows = 41; heifers = 17). Vaccination occurred between 60 to 50 days before the expected calving date with a single dose of a water-in-oil (W/O) vaccine, and NVAC group received a dose of saline solution 0.9%. Blood samples were collected before vaccination and 30 days after to evaluate the antibody (Ab) response. Specific IgG1 Abs
against BoRVA and BCoV were measured by using an Enzyme Linked Immuno Sorbent Assay (ELISA). Calves’ births were monitored, and the transference of passive immunity was evaluated. Diarrhea was monitored in the first 30 days of age, and fecal samples were collected for identification of the etiological agent.
Results: Higher titers of IgG1 Ab against BoRVA and BCoV was observed in the VAC group than NVAC group in the cow (P < 0.0001) and total dams categories (P < 0.0001). The titer of specific IgG1 Abs in the calves’ serum reflected the dams response, observing higher IgG1 Ab titers for BoRVA (P < 0.0016) and BCoV (P < 0.0095) in the offspring born to VAC cows and higher IgG1 Ab titers for BoRVA(P < 0.0171) and BCoV (P < 0.0200) in the offspring born to VAC total dams. The general incidence of diarrhea observed was 18.6% (11/59) and 29.3% (17/58) in the calves born to the VAC and NVAC group, respectively.
Conclusions: Prepartum vaccination with a single dose of the vaccine tested increased the titers of IgG1 Ab against BCoV and BoRVA, and it could be used as a preventive strategy to decrease the NCD occurrence in Nelore calves. |
| format | info:ar-repo/semantics/artículo |
| id | INTA12708 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | BioMed Central |
| publisherStr | BioMed Central |
| record_format | dspace |
| spelling | INTA127082022-08-29T10:28:57Z Efficacy of prepartum vaccination against neonatal calf diarrhea in Nelore dams as a prevention measure Pinheiro, Filipe Aguera Decaris, Nathália Parreño, Gladys Viviana Brandão, Paulo Eduardo Ayres, Henderson Gomes, Viviani Bovine Rotavirus Coronavirinae Calves Vaccination Diarrhoea Chemoprophylaxis Rotavirus bovino Ternero Vacunación Diarrea Profilaxis Química Bovine Coronavirus Coronavirus Bovino Background: Neonatal calf diarrhea (NCD) is the leading cause of calf morbidity and mortality in beef cattle. Cow’s vaccination in last stage of pregnancy is one of the most important measures to mitigate the risk of NCD outbreaks. The aim of this study was to evaluate the efficacy of prepartum single dose vaccination against NCD, especially Bovine Rotavirus type A (BoRVA) and Bovine Coronavirus (BCoV), in Nelore dams and offspring. A total of 117 pregnant cows (n = 81) and heifers (n = 36) were distributed in two groups, vaccinated (VAC: cows = 40; heifers = 19) and nonvaccinated (NVAC: cows = 41; heifers = 17). Vaccination occurred between 60 to 50 days before the expected calving date with a single dose of a water-in-oil (W/O) vaccine, and NVAC group received a dose of saline solution 0.9%. Blood samples were collected before vaccination and 30 days after to evaluate the antibody (Ab) response. Specific IgG1 Abs against BoRVA and BCoV were measured by using an Enzyme Linked Immuno Sorbent Assay (ELISA). Calves’ births were monitored, and the transference of passive immunity was evaluated. Diarrhea was monitored in the first 30 days of age, and fecal samples were collected for identification of the etiological agent. Results: Higher titers of IgG1 Ab against BoRVA and BCoV was observed in the VAC group than NVAC group in the cow (P < 0.0001) and total dams categories (P < 0.0001). The titer of specific IgG1 Abs in the calves’ serum reflected the dams response, observing higher IgG1 Ab titers for BoRVA (P < 0.0016) and BCoV (P < 0.0095) in the offspring born to VAC cows and higher IgG1 Ab titers for BoRVA(P < 0.0171) and BCoV (P < 0.0200) in the offspring born to VAC total dams. The general incidence of diarrhea observed was 18.6% (11/59) and 29.3% (17/58) in the calves born to the VAC and NVAC group, respectively. Conclusions: Prepartum vaccination with a single dose of the vaccine tested increased the titers of IgG1 Ab against BCoV and BoRVA, and it could be used as a preventive strategy to decrease the NCD occurrence in Nelore calves. Instituto de Virología Fil: Pinheiro, Filipe Aguera. University of São Paulo. College of Veterinary Medicine and Animal Science. Department of Internal Medicine; Brasil Fil: Decaris, Nathália. University of São Paulo. College of Veterinary Medicine and Animal Science. Department of Internal Medicine; Brasil Fil: Parreño, Gladys Viviana. Instituto Nacional de Tecnología Agropecuaria (INTA). INCUINTA. Instituto de Virologia e Innovaciones Tecnologicas; Argentina Fil: Parreño, Gladys Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Brandão, Paulo Eduardo. University of São Paulo. College of Veterinary Medicine and Animal Science. Department of Preventive Veterinary Medicine and Animal Health of Internal Medicine; Brasil Fil: Ayres, Henderson. MSD Animal Health; Brasil Fil: Gomes, Viviani. University of São Paulo. College of Veterinary Medicine and Animal Science. Department of Internal Medicine; Brasil 2022-08-29T10:23:21Z 2022-08-29T10:23:21Z 2022-08 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/12708 https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-022-03391-5 1746-6148 https://doi.org/10.1186/s12917-022-03391-5 eng info:eu-repograntAgreement/INTA/2019-PD-E5-I102-001/2019-PD-E5-I102-001/AR./Desarrollo de vacunas y tecnologías para mejorar las estrategias profilácticas y terapéuticas de las enfermedades que afectan la producción animal y la salud pública info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf BioMed Central BMC Veterinary Research 18 : 323 (Agosto 2022) |
| spellingShingle | Bovine Rotavirus Coronavirinae Calves Vaccination Diarrhoea Chemoprophylaxis Rotavirus bovino Ternero Vacunación Diarrea Profilaxis Química Bovine Coronavirus Coronavirus Bovino Pinheiro, Filipe Aguera Decaris, Nathália Parreño, Gladys Viviana Brandão, Paulo Eduardo Ayres, Henderson Gomes, Viviani Efficacy of prepartum vaccination against neonatal calf diarrhea in Nelore dams as a prevention measure |
| title | Efficacy of prepartum vaccination against neonatal calf diarrhea in Nelore dams as a prevention measure |
| title_full | Efficacy of prepartum vaccination against neonatal calf diarrhea in Nelore dams as a prevention measure |
| title_fullStr | Efficacy of prepartum vaccination against neonatal calf diarrhea in Nelore dams as a prevention measure |
| title_full_unstemmed | Efficacy of prepartum vaccination against neonatal calf diarrhea in Nelore dams as a prevention measure |
| title_short | Efficacy of prepartum vaccination against neonatal calf diarrhea in Nelore dams as a prevention measure |
| title_sort | efficacy of prepartum vaccination against neonatal calf diarrhea in nelore dams as a prevention measure |
| topic | Bovine Rotavirus Coronavirinae Calves Vaccination Diarrhoea Chemoprophylaxis Rotavirus bovino Ternero Vacunación Diarrea Profilaxis Química Bovine Coronavirus Coronavirus Bovino |
| url | http://hdl.handle.net/20.500.12123/12708 https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-022-03391-5 https://doi.org/10.1186/s12917-022-03391-5 |
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