Assessment on different vaccine formulation parameters in the protection against heterologous challenge with FMDV in cattle
Foot-and-mouth disease (FMD) remains one of the major threats to animal health worldwide. Its causative agent, the FMD virus (FMDV), affects cloven-hoofed animals, including farm animals and wildlife species, inflicting severe damage to the international trade and livestock industry. FMDV antigenic...
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| Format: | info:ar-repo/semantics/artículo |
| Language: | Inglés |
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MDPI
2022
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| Online Access: | http://hdl.handle.net/20.500.12123/12671 https://www.mdpi.com/1999-4915/14/8/1781 https://doi.org/10.3390/v14081781 |
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| author | Di Giacomo, Sebastián Bucafusco, Danilo Schammas, Juan Manuel Pega, Juan Franco Miraglia, Maria Cruz Barrionuevo, Florencia Mabel Capozzo, Alejandra Perez Filgueira, Daniel Mariano |
| author_browse | Barrionuevo, Florencia Mabel Bucafusco, Danilo Capozzo, Alejandra Di Giacomo, Sebastián Miraglia, Maria Cruz Pega, Juan Franco Perez Filgueira, Daniel Mariano Schammas, Juan Manuel |
| author_facet | Di Giacomo, Sebastián Bucafusco, Danilo Schammas, Juan Manuel Pega, Juan Franco Miraglia, Maria Cruz Barrionuevo, Florencia Mabel Capozzo, Alejandra Perez Filgueira, Daniel Mariano |
| author_sort | Di Giacomo, Sebastián |
| collection | INTA Digital |
| description | Foot-and-mouth disease (FMD) remains one of the major threats to animal health worldwide. Its causative agent, the FMD virus (FMDV), affects cloven-hoofed animals, including farm animals and wildlife species, inflicting severe damage to the international trade and livestock industry. FMDV antigenic variability remains one of the biggest challenges for vaccine-based control strategies. The current study analyzed the host’s adaptive immune responses in cattle immunized with different vaccine protocols and investigated its associations with the clinical outcome after infection with a heterologous strain of FMDV. The results showed that antigenic payload, multivalency, and revaccination may impact on the clinical outcome after heterologous challenge with FMDV. Protection from the experimental infection was related to qualitative traits of the elicited antibodies, such as avidity, IgG isotype composition, and specificity diversity, modulating and reflecting the vaccine-induced maturation of the humoral response. The correlation analyses of the serum avidity obtained per vaccinated individual might suggest that conventional vaccination can induce high-affinity immunoglobulins against conserved epitopes even within different FMDV serotypes. Cross-reaction among strains by these high-affinity antibodies may support further protection against a heterologous infection with FMDV. |
| format | info:ar-repo/semantics/artículo |
| id | INTA12671 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI |
| publisherStr | MDPI |
| record_format | dspace |
| spelling | INTA126712022-08-24T15:51:35Z Assessment on different vaccine formulation parameters in the protection against heterologous challenge with FMDV in cattle Di Giacomo, Sebastián Bucafusco, Danilo Schammas, Juan Manuel Pega, Juan Franco Miraglia, Maria Cruz Barrionuevo, Florencia Mabel Capozzo, Alejandra Perez Filgueira, Daniel Mariano Aphthovirus Cattle Vaccines Immunization Virus Fiebre Aftosa Ganado Bovino Vacuna Inmunización Foot-and-mouth disease (FMD) remains one of the major threats to animal health worldwide. Its causative agent, the FMD virus (FMDV), affects cloven-hoofed animals, including farm animals and wildlife species, inflicting severe damage to the international trade and livestock industry. FMDV antigenic variability remains one of the biggest challenges for vaccine-based control strategies. The current study analyzed the host’s adaptive immune responses in cattle immunized with different vaccine protocols and investigated its associations with the clinical outcome after infection with a heterologous strain of FMDV. The results showed that antigenic payload, multivalency, and revaccination may impact on the clinical outcome after heterologous challenge with FMDV. Protection from the experimental infection was related to qualitative traits of the elicited antibodies, such as avidity, IgG isotype composition, and specificity diversity, modulating and reflecting the vaccine-induced maturation of the humoral response. The correlation analyses of the serum avidity obtained per vaccinated individual might suggest that conventional vaccination can induce high-affinity immunoglobulins against conserved epitopes even within different FMDV serotypes. Cross-reaction among strains by these high-affinity antibodies may support further protection against a heterologous infection with FMDV. Instituto de Virología Fil: Di Giacomo, Sebastián. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina Fil: Di Giacomo, Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Bucafusco, Danilo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina Fil: Bucafusco, Danilo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Schammas, Juan Manuel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina Fil: Schammas, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Pega, Juan Franco. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina Fil: Pega, Juan Franco. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Miraglia, Maria Cruz. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina Fil: Miraglia, Maria Cruz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Barrionuevo, Florencia Mabel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina Fil: Barrionuevo, Florencia Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Capozzo, Alejandra. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina Fil: Capozzo, Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Perez Filgueira, Daniel Mariano. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina Fil: Perez Filgueira, Daniel Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina 2022-08-24T15:47:19Z 2022-08-24T15:47:19Z 2022-08 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/12671 https://www.mdpi.com/1999-4915/14/8/1781 1999-4915 https://doi.org/10.3390/v14081781 eng info:eu-repograntAgreement/INTA/PNSA-1115052/AR./Epidemiología y desarrollo de estrategias para la prevención y control de enfermedades que afectan la salud pública, enfermedades exóticas y limitantes del comercio internacional. info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf MDPI Viruses 14 (8) : 1781 (Agosto 2022) |
| spellingShingle | Aphthovirus Cattle Vaccines Immunization Virus Fiebre Aftosa Ganado Bovino Vacuna Inmunización Di Giacomo, Sebastián Bucafusco, Danilo Schammas, Juan Manuel Pega, Juan Franco Miraglia, Maria Cruz Barrionuevo, Florencia Mabel Capozzo, Alejandra Perez Filgueira, Daniel Mariano Assessment on different vaccine formulation parameters in the protection against heterologous challenge with FMDV in cattle |
| title | Assessment on different vaccine formulation parameters in the protection against heterologous challenge with FMDV in cattle |
| title_full | Assessment on different vaccine formulation parameters in the protection against heterologous challenge with FMDV in cattle |
| title_fullStr | Assessment on different vaccine formulation parameters in the protection against heterologous challenge with FMDV in cattle |
| title_full_unstemmed | Assessment on different vaccine formulation parameters in the protection against heterologous challenge with FMDV in cattle |
| title_short | Assessment on different vaccine formulation parameters in the protection against heterologous challenge with FMDV in cattle |
| title_sort | assessment on different vaccine formulation parameters in the protection against heterologous challenge with fmdv in cattle |
| topic | Aphthovirus Cattle Vaccines Immunization Virus Fiebre Aftosa Ganado Bovino Vacuna Inmunización |
| url | http://hdl.handle.net/20.500.12123/12671 https://www.mdpi.com/1999-4915/14/8/1781 https://doi.org/10.3390/v14081781 |
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