Pathogenicity of avibacterium paragallinarum strains from Peru and the selection of candidate strains for an inactivated vaccine
Worldwide, Avibacterium paragallinarum is the aetiological agent of infectious coryza in poultry. Vaccines are the best means of control, helping reduce clinical signs and colonization of this bacterium. Most vaccines are based on international reference strains, or, lately, regional strains, but, g...
| Autores principales: | , , , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
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MDPI
2022
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/12506 https://www.mdpi.com/2076-393X/10/7/1043 https://doi.org/10.3390/vaccines10071043 |
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| author | Caballero García, Melanie Mendoza Espinoza, Alfredo Ascanio, Silvia Chero, Paula Rojas, Rober Huberman, Yosef Daniel |
| author_browse | Ascanio, Silvia Caballero García, Melanie Chero, Paula Huberman, Yosef Daniel Mendoza Espinoza, Alfredo Rojas, Rober |
| author_facet | Caballero García, Melanie Mendoza Espinoza, Alfredo Ascanio, Silvia Chero, Paula Rojas, Rober Huberman, Yosef Daniel |
| author_sort | Caballero García, Melanie |
| collection | INTA Digital |
| description | Worldwide, Avibacterium paragallinarum is the aetiological agent of infectious coryza in poultry. Vaccines are the best means of control, helping reduce clinical signs and colonization of this bacterium. Most vaccines are based on international reference strains, or, lately, regional strains, but, generally, without any information regarding their virulence. The characterization of the pathogenicity of 24 Av. paragallinarum strains of the three Page serogroups, including four variant strains of serogroup B, all isolated from infectious coryza outbreaks in Peru, was performed. After experimental inoculation into the infraorbital sinuses, information regarding their capacity to induce infectious coryza typical clinical signs, spreading, and colonization was recorded. Furthermore, after intraperitoneal inoculation, septicaemia and death were registered. Differences among strains in these parameters were observed, even within strains from the same serogroup. Finally, the four most pathogenic strains, one from each serogroup, were chosen to formulate an experimental vaccine that was tested successfully against homologous challenges in reducing clinical signs and colonization in vaccinated birds compared to unvaccinated ones. This is the first time that Av. paragallinarum strains from Peru were studied thoroughly for their virulence in a search for improving vaccine formulation. |
| format | Artículo |
| id | INTA12506 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI |
| publisherStr | MDPI |
| record_format | dspace |
| spelling | INTA125062022-08-05T11:32:42Z Pathogenicity of avibacterium paragallinarum strains from Peru and the selection of candidate strains for an inactivated vaccine Caballero García, Melanie Mendoza Espinoza, Alfredo Ascanio, Silvia Chero, Paula Rojas, Rober Huberman, Yosef Daniel Aves de Corral Coriza Patogenicidad Vacuna Inactivada Poultry Coryza Pathogenicity Inactivated Vaccines Worldwide, Avibacterium paragallinarum is the aetiological agent of infectious coryza in poultry. Vaccines are the best means of control, helping reduce clinical signs and colonization of this bacterium. Most vaccines are based on international reference strains, or, lately, regional strains, but, generally, without any information regarding their virulence. The characterization of the pathogenicity of 24 Av. paragallinarum strains of the three Page serogroups, including four variant strains of serogroup B, all isolated from infectious coryza outbreaks in Peru, was performed. After experimental inoculation into the infraorbital sinuses, information regarding their capacity to induce infectious coryza typical clinical signs, spreading, and colonization was recorded. Furthermore, after intraperitoneal inoculation, septicaemia and death were registered. Differences among strains in these parameters were observed, even within strains from the same serogroup. Finally, the four most pathogenic strains, one from each serogroup, were chosen to formulate an experimental vaccine that was tested successfully against homologous challenges in reducing clinical signs and colonization in vaccinated birds compared to unvaccinated ones. This is the first time that Av. paragallinarum strains from Peru were studied thoroughly for their virulence in a search for improving vaccine formulation. EEA Balcarce Fil: Caballero Garcia, Melanie. Quimtia. Research and Development; Perú. Fil: Mendoza Espinoza, Alfredo. Quimtia. Research and Development; Perú. Fil: Ascanio, Silvia. Quimtia. Research and Development; Perú. Fil: Chero, Paula. Quimtia. Research and Development; Perú. Fil: Rojas, Rober. Quimtia. Research and Development; Perú. Fil: Huberman, Yosef Daniel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina. 2022-08-05T11:28:46Z 2022-08-05T11:28:46Z 2022-06-29 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/12506 https://www.mdpi.com/2076-393X/10/7/1043 2076-393X https://doi.org/10.3390/vaccines10071043 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf MDPI Vaccines 10 (7) : 1043 (July 2022) |
| spellingShingle | Aves de Corral Coriza Patogenicidad Vacuna Inactivada Poultry Coryza Pathogenicity Inactivated Vaccines Caballero García, Melanie Mendoza Espinoza, Alfredo Ascanio, Silvia Chero, Paula Rojas, Rober Huberman, Yosef Daniel Pathogenicity of avibacterium paragallinarum strains from Peru and the selection of candidate strains for an inactivated vaccine |
| title | Pathogenicity of avibacterium paragallinarum strains from Peru and the selection of candidate strains for an inactivated vaccine |
| title_full | Pathogenicity of avibacterium paragallinarum strains from Peru and the selection of candidate strains for an inactivated vaccine |
| title_fullStr | Pathogenicity of avibacterium paragallinarum strains from Peru and the selection of candidate strains for an inactivated vaccine |
| title_full_unstemmed | Pathogenicity of avibacterium paragallinarum strains from Peru and the selection of candidate strains for an inactivated vaccine |
| title_short | Pathogenicity of avibacterium paragallinarum strains from Peru and the selection of candidate strains for an inactivated vaccine |
| title_sort | pathogenicity of avibacterium paragallinarum strains from peru and the selection of candidate strains for an inactivated vaccine |
| topic | Aves de Corral Coriza Patogenicidad Vacuna Inactivada Poultry Coryza Pathogenicity Inactivated Vaccines |
| url | http://hdl.handle.net/20.500.12123/12506 https://www.mdpi.com/2076-393X/10/7/1043 https://doi.org/10.3390/vaccines10071043 |
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