The efficacy of a trivalent inactivated salmonella vaccine combined with the live s. gallinarum 9R vaccine in young layers after experimental infections with s. enteritidis, s. typhimurium, and s. infantis
Worldwide, poultry infections by Salmonella are the cause of significant economic losses, not only due to reduced production (due to fowl typhoid disease), but also considering the efforts and control measures that must be constantly applied, especially due to zoonotic serovars. Poultry is a common...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
| Publicado: |
MDPI
2022
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/12505 https://www.mdpi.com/2076-393X/10/7/1113 https://doi.org/10.3390/vaccines10071113 |
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| author | Huberman, Yosef Daniel Caballero García, Melanie Rojas, Rober Ascanio, Silvia. Olmos, Leandro Hipolito Malena, Rosana Claudia Lomonaco, Jorgelina Nievas, Paula Andrea Chero, Paula Lévano Gracía, Julio Mendoza Espinoza, Alfredo |
| author_browse | Ascanio, Silvia. Caballero García, Melanie Chero, Paula Huberman, Yosef Daniel Lomonaco, Jorgelina Lévano Gracía, Julio Malena, Rosana Claudia Mendoza Espinoza, Alfredo Nievas, Paula Andrea Olmos, Leandro Hipolito Rojas, Rober |
| author_facet | Huberman, Yosef Daniel Caballero García, Melanie Rojas, Rober Ascanio, Silvia. Olmos, Leandro Hipolito Malena, Rosana Claudia Lomonaco, Jorgelina Nievas, Paula Andrea Chero, Paula Lévano Gracía, Julio Mendoza Espinoza, Alfredo |
| author_sort | Huberman, Yosef Daniel |
| collection | INTA Digital |
| description | Worldwide, poultry infections by Salmonella are the cause of significant economic losses, not only due to reduced production (due to fowl typhoid disease), but also considering the efforts and control measures that must be constantly applied, especially due to zoonotic serovars. Poultry is a common reservoir of Salmonella and its transmission into the food chain is a risk for humans. The vaccination of layers plays an important role in the overall efforts to prevent Salmonella infections. An inactivated trivalent vaccine was prepared with S. Enteritidis, S. Typhimurium, and S. Infantis strains. Infection trials were performed to evaluate the efficacy of three vaccination schedules using inactivated and live S. Gallinarum 9R vaccines. For this purpose, at week 5 of life, one subcutaneous dose of live S. Gallinarum 9R vaccine (1–5 × 107 CFU) was given to Groups 1 and 2. At weeks 8 and 11 of life, chickens were also vaccinated with one (Group 1) or two (Groups 2 and 3) intramuscular doses of the inactivated oil-adjuvant trivalent vaccine (1 × 108 CFU/dose of each antigen). Group 4 consisted of chickens that remained unvaccinated (control). At week 14 of life, the efficacy of the vaccination plans was evaluated in three separate inoculation trials with S. Enteritidis, S. Typhimurium, or S. Infantis. After vaccination with the inactivated vaccine, homologous antibody production was observed, and after challenge, a significant reduction in the faecal shedding, invasion, and colonization of S. Typhimurium and S. Infantis was achieved by all vaccination schedules, while the vaccination with at least one dose of the live S. Gallinarum 9R vaccine was necessary to obtain such a significant protection against S. Enteritidis infection. |
| format | Artículo |
| id | INTA12505 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI |
| publisherStr | MDPI |
| record_format | dspace |
| spelling | INTA125052022-08-05T11:26:05Z The efficacy of a trivalent inactivated salmonella vaccine combined with the live s. gallinarum 9R vaccine in young layers after experimental infections with s. enteritidis, s. typhimurium, and s. infantis Huberman, Yosef Daniel Caballero García, Melanie Rojas, Rober Ascanio, Silvia. Olmos, Leandro Hipolito Malena, Rosana Claudia Lomonaco, Jorgelina Nievas, Paula Andrea Chero, Paula Lévano Gracía, Julio Mendoza Espinoza, Alfredo Pollo Vacuna Inactivada Salmonella Salmonella Enteritidis Salmonella Typhimurium Chickens Inactivated Vaccines Salmonella Infantis Worldwide, poultry infections by Salmonella are the cause of significant economic losses, not only due to reduced production (due to fowl typhoid disease), but also considering the efforts and control measures that must be constantly applied, especially due to zoonotic serovars. Poultry is a common reservoir of Salmonella and its transmission into the food chain is a risk for humans. The vaccination of layers plays an important role in the overall efforts to prevent Salmonella infections. An inactivated trivalent vaccine was prepared with S. Enteritidis, S. Typhimurium, and S. Infantis strains. Infection trials were performed to evaluate the efficacy of three vaccination schedules using inactivated and live S. Gallinarum 9R vaccines. For this purpose, at week 5 of life, one subcutaneous dose of live S. Gallinarum 9R vaccine (1–5 × 107 CFU) was given to Groups 1 and 2. At weeks 8 and 11 of life, chickens were also vaccinated with one (Group 1) or two (Groups 2 and 3) intramuscular doses of the inactivated oil-adjuvant trivalent vaccine (1 × 108 CFU/dose of each antigen). Group 4 consisted of chickens that remained unvaccinated (control). At week 14 of life, the efficacy of the vaccination plans was evaluated in three separate inoculation trials with S. Enteritidis, S. Typhimurium, or S. Infantis. After vaccination with the inactivated vaccine, homologous antibody production was observed, and after challenge, a significant reduction in the faecal shedding, invasion, and colonization of S. Typhimurium and S. Infantis was achieved by all vaccination schedules, while the vaccination with at least one dose of the live S. Gallinarum 9R vaccine was necessary to obtain such a significant protection against S. Enteritidis infection. EEA Balcarce Fil: Huberman, Yosef Daniel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina. Fil: Caballero Garcia, Melanie. Quimtia. Research and Development; Perú. Fil: Rojas, Rober. Quimtia. Research and Development; Perú. Fil: Ascanio, Silvia. Quimtia. Research and Development; Perú. Fil: Olmos, Leandro Hipólito. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina. Fil: Malena, Rosana Claudia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina. Fil: Lomónaco, Jorgelina. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina. Fil: Nievas, Paula Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina. Fil: Chero, Paula. Quimtia. Research and Development; Perú. Fil: Lévano Gracía, Julio. Quimtia. Research and Development; Perú. Fil: Mendoza Espinoza, Alfredo. Quimtia. Research and Development; Perú. 2022-08-05T11:13:38Z 2022-08-05T11:13:38Z 2022-07-12 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/12505 https://www.mdpi.com/2076-393X/10/7/1113 2076-393X https://doi.org/10.3390/vaccines10071113 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf MDPI Vaccines 10 (7) : 1113 (July 2022) |
| spellingShingle | Pollo Vacuna Inactivada Salmonella Salmonella Enteritidis Salmonella Typhimurium Chickens Inactivated Vaccines Salmonella Infantis Huberman, Yosef Daniel Caballero García, Melanie Rojas, Rober Ascanio, Silvia. Olmos, Leandro Hipolito Malena, Rosana Claudia Lomonaco, Jorgelina Nievas, Paula Andrea Chero, Paula Lévano Gracía, Julio Mendoza Espinoza, Alfredo The efficacy of a trivalent inactivated salmonella vaccine combined with the live s. gallinarum 9R vaccine in young layers after experimental infections with s. enteritidis, s. typhimurium, and s. infantis |
| title | The efficacy of a trivalent inactivated salmonella vaccine combined with the live s. gallinarum 9R vaccine in young layers after experimental infections with s. enteritidis, s. typhimurium, and s. infantis |
| title_full | The efficacy of a trivalent inactivated salmonella vaccine combined with the live s. gallinarum 9R vaccine in young layers after experimental infections with s. enteritidis, s. typhimurium, and s. infantis |
| title_fullStr | The efficacy of a trivalent inactivated salmonella vaccine combined with the live s. gallinarum 9R vaccine in young layers after experimental infections with s. enteritidis, s. typhimurium, and s. infantis |
| title_full_unstemmed | The efficacy of a trivalent inactivated salmonella vaccine combined with the live s. gallinarum 9R vaccine in young layers after experimental infections with s. enteritidis, s. typhimurium, and s. infantis |
| title_short | The efficacy of a trivalent inactivated salmonella vaccine combined with the live s. gallinarum 9R vaccine in young layers after experimental infections with s. enteritidis, s. typhimurium, and s. infantis |
| title_sort | efficacy of a trivalent inactivated salmonella vaccine combined with the live s gallinarum 9r vaccine in young layers after experimental infections with s enteritidis s typhimurium and s infantis |
| topic | Pollo Vacuna Inactivada Salmonella Salmonella Enteritidis Salmonella Typhimurium Chickens Inactivated Vaccines Salmonella Infantis |
| url | http://hdl.handle.net/20.500.12123/12505 https://www.mdpi.com/2076-393X/10/7/1113 https://doi.org/10.3390/vaccines10071113 |
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