Pathogenesis and immunobiology of brucellosis : review of brucella-host interactions
This review of Brucellaehost interactions and immunobiology discusses recent discoveries as the basis for pathogenesis-informed rationales to prevent or treat brucellosis. Brucella spp., as animal pathogens, cause human brucellosis, a zoonosis that results in worldwide economic losses, human morbidi...
| Main Authors: | , , , , |
|---|---|
| Format: | Artículo |
| Language: | Inglés |
| Published: |
Elsevier
2022
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.12123/12424 https://ajp.amjpathol.org/article/S0002-9440(15)00183-2/fulltext https://doi.org/10.1016/j.ajpath.2015.03.003 |
| _version_ | 1855484971019403264 |
|---|---|
| author | de Figueiredo, Paul Ficht, Thomas A. Rice-Ficht, Allison C. Rossetti, Carlos Alberto Adams, Leslie G. |
| author_browse | Adams, Leslie G. Ficht, Thomas A. Rice-Ficht, Allison C. Rossetti, Carlos Alberto de Figueiredo, Paul |
| author_facet | de Figueiredo, Paul Ficht, Thomas A. Rice-Ficht, Allison C. Rossetti, Carlos Alberto Adams, Leslie G. |
| author_sort | de Figueiredo, Paul |
| collection | INTA Digital |
| description | This review of Brucellaehost interactions and immunobiology discusses recent discoveries as the basis for pathogenesis-informed rationales to prevent or treat brucellosis. Brucella spp., as animal pathogens, cause human brucellosis, a zoonosis that results in worldwide economic losses, human morbidity, and poverty. Although Brucella spp. infect humans as an incidental host, 500,000 new human infections occur annually, and no patient-friendly treatments or approved human vaccines are reported. Brucellae display strong tissue tropism for lymphoreticular and reproductive systems with an intracellular lifestyle that limitsn exposure to innate and adaptive immune responses, sequesters the organism from the effects of antibiotics, and drives clinical disease manifestations and pathology. Stealthy brucellae exploit strategies to establish infection, including i) evasion of intracellular destruction by restricting fusion of type IV secretion systemdependent Brucella-containing vacuoles with lysosomal compartments, ii) inhibition of apoptosis of infected mononuclear cells, and iii) prevention of dendritic cell maturation, antigen presentation, and activation of naive T cells, pathogenesis lessons that may be informative for other intracellular pathogens. Data sets of next-generation sequences of Brucella and host time-series global expression fused with proteomics and metabolomics data from in vitro and in vivo experiments now inform interactive cellular pathways and gene regulatory networks enabling full-scale systems biology analysis. The newly identified effector proteins of Brucella may represent targets for improved, safer brucellosis vaccines and therapeutics. |
| format | Artículo |
| id | INTA12424 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | INTA124242022-07-28T10:29:20Z Pathogenesis and immunobiology of brucellosis : review of brucella-host interactions de Figueiredo, Paul Ficht, Thomas A. Rice-Ficht, Allison C. Rossetti, Carlos Alberto Adams, Leslie G. Pathogenesis Brucellosis Patogénesis Brucelosis Brucella Immunobiology Host–microbe Interactions Inmunobiología Interacciones Huésped-microbio This review of Brucellaehost interactions and immunobiology discusses recent discoveries as the basis for pathogenesis-informed rationales to prevent or treat brucellosis. Brucella spp., as animal pathogens, cause human brucellosis, a zoonosis that results in worldwide economic losses, human morbidity, and poverty. Although Brucella spp. infect humans as an incidental host, 500,000 new human infections occur annually, and no patient-friendly treatments or approved human vaccines are reported. Brucellae display strong tissue tropism for lymphoreticular and reproductive systems with an intracellular lifestyle that limitsn exposure to innate and adaptive immune responses, sequesters the organism from the effects of antibiotics, and drives clinical disease manifestations and pathology. Stealthy brucellae exploit strategies to establish infection, including i) evasion of intracellular destruction by restricting fusion of type IV secretion systemdependent Brucella-containing vacuoles with lysosomal compartments, ii) inhibition of apoptosis of infected mononuclear cells, and iii) prevention of dendritic cell maturation, antigen presentation, and activation of naive T cells, pathogenesis lessons that may be informative for other intracellular pathogens. Data sets of next-generation sequences of Brucella and host time-series global expression fused with proteomics and metabolomics data from in vitro and in vivo experiments now inform interactive cellular pathways and gene regulatory networks enabling full-scale systems biology analysis. The newly identified effector proteins of Brucella may represent targets for improved, safer brucellosis vaccines and therapeutics. Instituto de Patobiología Fil: de Figueiredo, Paul. Texas A&M University. Department of Veterinary Pathobiology; Estados Unidos Fil: de Figueiredo, Paul. Texas AgriLife Research; Estados Unidos Fil: de Figueiredo, Paul. Texas A&M University. Norman Borlaug Center; Estados Unidos Fil: de Figueiredo, Paul. Texas A&M Health Science Center. Department of Microbial Pathogenesis and Immunology; Estados Unidos Fil: Ficht, Thomas A. Texas A&M University. College of Veterinary Medicine & Biomedical Sciences. Department of Veterinary Pathobiology; Estados Unidos Fil: Rice-Ficht, Allison C. Texas A&M University. College of Medicine. Department of Molecular and Cellular Medicine; Estados Unidos Fil: Rossetti, Carlos Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina Fil: Adams, Leslie G. Texas A&M University. College of Veterinary Medicine & Biomedical Sciences. Department of Veterinary Pathobiology; Estados Unidos 2022-07-28T10:22:36Z 2022-07-28T10:22:36Z 2015-06 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/12424 https://ajp.amjpathol.org/article/S0002-9440(15)00183-2/fulltext 1525-2191 https://doi.org/10.1016/j.ajpath.2015.03.003 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Elsevier The American Journal of Pathology 185 (6) : 1505-1517 (Junio 2015) |
| spellingShingle | Pathogenesis Brucellosis Patogénesis Brucelosis Brucella Immunobiology Host–microbe Interactions Inmunobiología Interacciones Huésped-microbio de Figueiredo, Paul Ficht, Thomas A. Rice-Ficht, Allison C. Rossetti, Carlos Alberto Adams, Leslie G. Pathogenesis and immunobiology of brucellosis : review of brucella-host interactions |
| title | Pathogenesis and immunobiology of brucellosis : review of brucella-host interactions |
| title_full | Pathogenesis and immunobiology of brucellosis : review of brucella-host interactions |
| title_fullStr | Pathogenesis and immunobiology of brucellosis : review of brucella-host interactions |
| title_full_unstemmed | Pathogenesis and immunobiology of brucellosis : review of brucella-host interactions |
| title_short | Pathogenesis and immunobiology of brucellosis : review of brucella-host interactions |
| title_sort | pathogenesis and immunobiology of brucellosis review of brucella host interactions |
| topic | Pathogenesis Brucellosis Patogénesis Brucelosis Brucella Immunobiology Host–microbe Interactions Inmunobiología Interacciones Huésped-microbio |
| url | http://hdl.handle.net/20.500.12123/12424 https://ajp.amjpathol.org/article/S0002-9440(15)00183-2/fulltext https://doi.org/10.1016/j.ajpath.2015.03.003 |
| work_keys_str_mv | AT defigueiredopaul pathogenesisandimmunobiologyofbrucellosisreviewofbrucellahostinteractions AT fichtthomasa pathogenesisandimmunobiologyofbrucellosisreviewofbrucellahostinteractions AT ricefichtallisonc pathogenesisandimmunobiologyofbrucellosisreviewofbrucellahostinteractions AT rossetticarlosalberto pathogenesisandimmunobiologyofbrucellosisreviewofbrucellahostinteractions AT adamsleslieg pathogenesisandimmunobiologyofbrucellosisreviewofbrucellahostinteractions |