Chemical Composition of Argentinean Propolis Collected in Extreme Regions and its Relation with Antimicrobial and Antioxidant Activities
This paper reveals, for the first time, the functional properties of propolis from an extreme region of Argentine (El Rincón, Province of Catamarca, Argentina), as well as the isolation and identification of bioactive compounds. The antioxidant activity was determined by the ABTS method and β-carote...
| Main Authors: | , , , , , |
|---|---|
| Format: | Artículo |
| Language: | Inglés |
| Published: |
Sage Publishing
2022
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.12123/12357 https://journals.sagepub.com/doi/abs/10.1177/1934578X1100600618 https://doi.org/10.1177/1934578X1100600618 |
| _version_ | 1855484957764354048 |
|---|---|
| author | Vera, Nancy Roxana Solórzano, Eliana Ordóñez, Roxana Mabel Maldonado, Luis Maria Bedascarrasbure, Enrique Luciano Isla, María Inés |
| author_browse | Bedascarrasbure, Enrique Luciano Isla, María Inés Maldonado, Luis Maria Ordóñez, Roxana Mabel Solórzano, Eliana Vera, Nancy Roxana |
| author_facet | Vera, Nancy Roxana Solórzano, Eliana Ordóñez, Roxana Mabel Maldonado, Luis Maria Bedascarrasbure, Enrique Luciano Isla, María Inés |
| author_sort | Vera, Nancy Roxana |
| collection | INTA Digital |
| description | This paper reveals, for the first time, the functional properties of propolis from an extreme region of Argentine (El Rincón, Province of Catamarca, Argentina), as well as the isolation and identification of bioactive compounds. The antioxidant activity was determined by the ABTS method and β-carotene bleaching. The antibacterial activity was determined on methicillin resistant Staphylococcus aureus (MRSA) by the microdilution method and bioautographic assays. Twelve compounds were isolated and identified by NMR spectroscopy. The main bioactive compounds were 2′,4′-dihydroxy-3′-methoxychalcone (3), 2′,4′-dihydroxychalcone (9), 2′,4′,4-trihydroxy-6′- methoxychalcone (8), 5-hydroxy-4′,7-dimethoxyflavone (4), 4′,5-dihydroxy-3,7,8-trimethoxyflavone (10) and 7-hydroxy- 5,8-dimethoxyflavone (11). All compounds were active against clinical isolates (MIC50 10 μg/ mL) and displayed antioxidant activity (SC50 values of 20 μg/mL). The MIC and SC50 values of the isolated compounds were lower than those obtained with crude propolis extracts, chloroform sub-extracts and isolated fractions. |
| format | Artículo |
| id | INTA12357 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | Sage Publishing |
| publisherStr | Sage Publishing |
| record_format | dspace |
| spelling | INTA123572022-07-20T10:51:41Z Chemical Composition of Argentinean Propolis Collected in Extreme Regions and its Relation with Antimicrobial and Antioxidant Activities Vera, Nancy Roxana Solórzano, Eliana Ordóñez, Roxana Mabel Maldonado, Luis Maria Bedascarrasbure, Enrique Luciano Isla, María Inés Propóleos Composición Quimica Propiedades Antimicrobianas Propiedades Antioxidantes Argentina Propolis Chemical Composition Antimicrobial Properties Antioxidant Properties cientifico This paper reveals, for the first time, the functional properties of propolis from an extreme region of Argentine (El Rincón, Province of Catamarca, Argentina), as well as the isolation and identification of bioactive compounds. The antioxidant activity was determined by the ABTS method and β-carotene bleaching. The antibacterial activity was determined on methicillin resistant Staphylococcus aureus (MRSA) by the microdilution method and bioautographic assays. Twelve compounds were isolated and identified by NMR spectroscopy. The main bioactive compounds were 2′,4′-dihydroxy-3′-methoxychalcone (3), 2′,4′-dihydroxychalcone (9), 2′,4′,4-trihydroxy-6′- methoxychalcone (8), 5-hydroxy-4′,7-dimethoxyflavone (4), 4′,5-dihydroxy-3,7,8-trimethoxyflavone (10) and 7-hydroxy- 5,8-dimethoxyflavone (11). All compounds were active against clinical isolates (MIC50 10 μg/ mL) and displayed antioxidant activity (SC50 values of 20 μg/mL). The MIC and SC50 values of the isolated compounds were lower than those obtained with crude propolis extracts, chloroform sub-extracts and isolated fractions. EEA Famaillá Fil: Vera, Nancy Roxana. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina Fil: Vera, Nancy Roxana. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Famaillá; Argentina Fil: Solórzano, Eliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto de Química del Noroeste; Argentina Fil: Ordóñez, Roxana Mabel. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina Fil: Ordóñez, Roxana Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto de Quimica del Noroeste; Argentina. Fil: Maldonado, Luis Maria. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Famaillá; Argentina Fil: Bedascarrasbure, Enrique Luciano. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Famaillá; Argentina Fil: Isla, Maria Ines. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina Fil: Isla, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto de Quimica del Noroeste; Argentina 2022-07-20T10:48:32Z 2022-07-20T10:48:32Z 2011-06 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/12357 https://journals.sagepub.com/doi/abs/10.1177/1934578X1100600618 1934-578X 1555-9475 https://doi.org/10.1177/1934578X1100600618 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Argentina .......... (nation) (World, South America) 7006477 Sage Publishing Natural Product Communications 6 (6) : 823-827 (June 2011) |
| spellingShingle | Propóleos Composición Quimica Propiedades Antimicrobianas Propiedades Antioxidantes Argentina Propolis Chemical Composition Antimicrobial Properties Antioxidant Properties cientifico Vera, Nancy Roxana Solórzano, Eliana Ordóñez, Roxana Mabel Maldonado, Luis Maria Bedascarrasbure, Enrique Luciano Isla, María Inés Chemical Composition of Argentinean Propolis Collected in Extreme Regions and its Relation with Antimicrobial and Antioxidant Activities |
| title | Chemical Composition of Argentinean Propolis Collected in Extreme Regions and its Relation with Antimicrobial and Antioxidant Activities |
| title_full | Chemical Composition of Argentinean Propolis Collected in Extreme Regions and its Relation with Antimicrobial and Antioxidant Activities |
| title_fullStr | Chemical Composition of Argentinean Propolis Collected in Extreme Regions and its Relation with Antimicrobial and Antioxidant Activities |
| title_full_unstemmed | Chemical Composition of Argentinean Propolis Collected in Extreme Regions and its Relation with Antimicrobial and Antioxidant Activities |
| title_short | Chemical Composition of Argentinean Propolis Collected in Extreme Regions and its Relation with Antimicrobial and Antioxidant Activities |
| title_sort | chemical composition of argentinean propolis collected in extreme regions and its relation with antimicrobial and antioxidant activities |
| topic | Propóleos Composición Quimica Propiedades Antimicrobianas Propiedades Antioxidantes Argentina Propolis Chemical Composition Antimicrobial Properties Antioxidant Properties cientifico |
| url | http://hdl.handle.net/20.500.12123/12357 https://journals.sagepub.com/doi/abs/10.1177/1934578X1100600618 https://doi.org/10.1177/1934578X1100600618 |
| work_keys_str_mv | AT veranancyroxana chemicalcompositionofargentineanpropoliscollectedinextremeregionsanditsrelationwithantimicrobialandantioxidantactivities AT solorzanoeliana chemicalcompositionofargentineanpropoliscollectedinextremeregionsanditsrelationwithantimicrobialandantioxidantactivities AT ordonezroxanamabel chemicalcompositionofargentineanpropoliscollectedinextremeregionsanditsrelationwithantimicrobialandantioxidantactivities AT maldonadoluismaria chemicalcompositionofargentineanpropoliscollectedinextremeregionsanditsrelationwithantimicrobialandantioxidantactivities AT bedascarrasbureenriqueluciano chemicalcompositionofargentineanpropoliscollectedinextremeregionsanditsrelationwithantimicrobialandantioxidantactivities AT islamariaines chemicalcompositionofargentineanpropoliscollectedinextremeregionsanditsrelationwithantimicrobialandantioxidantactivities |