Review of antiviral peptides for use against zoonotic and selected non-zoonotic viruses
Viruses remain one of the leading causes of animal and human disease. Some animal viral infections spread sporadically to human populations, posing a serious health risk. Particularly the emerging viral zoonotic diseases such as the novel, zoonotic coronavirus represent an actual challenge for the s...
| Autores principales: | , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier
2022
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| Acceso en línea: | http://hdl.handle.net/20.500.12123/12019 https://www.sciencedirect.com/science/article/pii/S0196978121000784 https://doi.org/10.1016/j.peptides.2021.170570 |
| _version_ | 1855484892995911680 |
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| author | Hollmann, Axel Cardoso, Nancy Espeche, Juan C. Maffía, Paulo C. |
| author_browse | Cardoso, Nancy Espeche, Juan C. Hollmann, Axel Maffía, Paulo C. |
| author_facet | Hollmann, Axel Cardoso, Nancy Espeche, Juan C. Maffía, Paulo C. |
| author_sort | Hollmann, Axel |
| collection | INTA Digital |
| description | Viruses remain one of the leading causes of animal and human disease. Some animal viral infections spread sporadically to human populations, posing a serious health risk. Particularly the emerging viral zoonotic diseases such as the novel, zoonotic coronavirus represent an actual challenge for the scientific and medical community. Besides human health risks, some animal viral infections, although still not zoonotic, represent important economic loses to the livestock industry. Viral infections pose a genuine concern for which there has been an increasing interest for new antiviral molecules. Among these novel compounds, antiviral peptides have been proposed as promising therapeutic options, not only for the growing body of evidence showing hopeful results but also due to the many adverse effects of chemical-based drugs. Here we review the current progress, key targets and considerations for the development of antiviral peptides (AVPs). The review summarizes the state of the art of the AVPs tested in zoonotic (coronaviruses, Rift Valley fever viruses, Eastern Equine Encephalitis Virus, Dengue and Junín virus) and also non-zoonotic farm animal viruses (avian and cattle viruses). Their molecular target, amino acid sequence and mechanism of action are summarized and reviewed.
Antiviral peptides are currently on the cutting edge since they have been reported to display anti-coronavirus activity. Particularly, the review will discuss the specific mode of action of AVPs that specifically inhibit the fusion of viral and host-cell membranes for SARS-CoV-2, showing in detail some important features of the fusion inhibiting peptides that target the spike protein of these risky viruses. |
| format | Artículo |
| id | INTA12019 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | INTA120192022-06-06T10:40:17Z Review of antiviral peptides for use against zoonotic and selected non-zoonotic viruses Hollmann, Axel Cardoso, Nancy Espeche, Juan C. Maffía, Paulo C. Peptides Antiviral Agents Zoonoses Animal Viruses Péptidos Viricidas Zoonosis Virus de los Animales COVID-19 Viruses remain one of the leading causes of animal and human disease. Some animal viral infections spread sporadically to human populations, posing a serious health risk. Particularly the emerging viral zoonotic diseases such as the novel, zoonotic coronavirus represent an actual challenge for the scientific and medical community. Besides human health risks, some animal viral infections, although still not zoonotic, represent important economic loses to the livestock industry. Viral infections pose a genuine concern for which there has been an increasing interest for new antiviral molecules. Among these novel compounds, antiviral peptides have been proposed as promising therapeutic options, not only for the growing body of evidence showing hopeful results but also due to the many adverse effects of chemical-based drugs. Here we review the current progress, key targets and considerations for the development of antiviral peptides (AVPs). The review summarizes the state of the art of the AVPs tested in zoonotic (coronaviruses, Rift Valley fever viruses, Eastern Equine Encephalitis Virus, Dengue and Junín virus) and also non-zoonotic farm animal viruses (avian and cattle viruses). Their molecular target, amino acid sequence and mechanism of action are summarized and reviewed. Antiviral peptides are currently on the cutting edge since they have been reported to display anti-coronavirus activity. Particularly, the review will discuss the specific mode of action of AVPs that specifically inhibit the fusion of viral and host-cell membranes for SARS-CoV-2, showing in detail some important features of the fusion inhibiting peptides that target the spike protein of these risky viruses. Instituto de Virología Fil: Hollmann, Axel. Universidad Nacional de Santiago del Estero. Centro de Investigaciones en Biofísica Aplicada y Alimentos (CIBAAL). Laboratorio de Compuestos Bioactivos; Argentina Fil: Hollmann, Axel. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina Fil: Hollmann, Axel. Universidad Nacional de Quilmes. Instituto de Microbiología Básica y Aplicada. Laboratorio de Microbiología Molecular; Argentina Fil: Cardoso, Nancy. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; Argentina Fil: Cardoso, Nancy. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina Fil: Espeche, Juan C. Universidad Nacional de Santiago del Estero. Centro de Investigaciones en Biofísica Aplicada y Alimentos (CIBAAL). Laboratorio de Compuestos Bioactivos; Argentina Fil: Espeche, Juan C. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina Fil: Maffía, Paulo C. Universidad Nacional de Hurlingham. Instituto de Biotecnología; Argentina Fil: Maffía, Paulo C. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina 2022-06-06T10:35:16Z 2022-06-06T10:35:16Z 2021-08 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/12019 https://www.sciencedirect.com/science/article/pii/S0196978121000784 1873-5169 https://doi.org/10.1016/j.peptides.2021.170570 eng info:eu-repo/semantics/restrictedAccess application/pdf Elsevier Peptides 142 : 170570 (Agosto 2021) |
| spellingShingle | Peptides Antiviral Agents Zoonoses Animal Viruses Péptidos Viricidas Zoonosis Virus de los Animales COVID-19 Hollmann, Axel Cardoso, Nancy Espeche, Juan C. Maffía, Paulo C. Review of antiviral peptides for use against zoonotic and selected non-zoonotic viruses |
| title | Review of antiviral peptides for use against zoonotic and selected non-zoonotic viruses |
| title_full | Review of antiviral peptides for use against zoonotic and selected non-zoonotic viruses |
| title_fullStr | Review of antiviral peptides for use against zoonotic and selected non-zoonotic viruses |
| title_full_unstemmed | Review of antiviral peptides for use against zoonotic and selected non-zoonotic viruses |
| title_short | Review of antiviral peptides for use against zoonotic and selected non-zoonotic viruses |
| title_sort | review of antiviral peptides for use against zoonotic and selected non zoonotic viruses |
| topic | Peptides Antiviral Agents Zoonoses Animal Viruses Péptidos Viricidas Zoonosis Virus de los Animales COVID-19 |
| url | http://hdl.handle.net/20.500.12123/12019 https://www.sciencedirect.com/science/article/pii/S0196978121000784 https://doi.org/10.1016/j.peptides.2021.170570 |
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