Thrombospondin related anonymous protein superfamily in vector-borne apicomplexans: the parasite’s toolkit for cell invasion
Apicomplexan parasites transmitted by vectors, including Babesia spp. and Plasmodium spp., cause severe disease in both humans and animals. These parasites have a complex life cycle during which they migrate, invade, and replicate in contrasting hosts such as the mammal and the invertebrate vector....
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| Format: | Artículo |
| Language: | Inglés |
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Frontiers Media
2022
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| Online Access: | http://hdl.handle.net/20.500.12123/11838 https://www.frontiersin.org/articles/10.3389/fcimb.2022.831592/full https://doi.org/10.3389/fcimb.2022.831592 |
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| author | Paoletta, Martina Wilkowsky, Silvina Elizabeth |
| author_browse | Paoletta, Martina Wilkowsky, Silvina Elizabeth |
| author_facet | Paoletta, Martina Wilkowsky, Silvina Elizabeth |
| author_sort | Paoletta, Martina |
| collection | INTA Digital |
| description | Apicomplexan parasites transmitted by vectors, including Babesia spp. and Plasmodium spp., cause severe disease in both humans and animals. These parasites have a complex life cycle during which they migrate, invade, and replicate in contrasting hosts such as the mammal and the invertebrate vector. The interaction of parasites with the host cell is mediated by adhesive proteins which play a key role in the different cellular processes regarding successful progression of the life cycle. Thrombospondin related anonymous protein (TRAP) is a superfamily of adhesins that are involved in motility, invasion and egress of the parasite. These proteins are stored and released from apical organelles and have either one or two types of adhesive domains, namely thrombospondin type 1 repeat and von Willebrand factor type A, that upon secretion are located in the extracellular portion of the molecule. Proteins from the TRAP superfamily have been intensively studied in Plasmodium species and to a lesser extent in Babesia spp., where they have proven to be functionally relevant throughout the entire parasite’s journey both in the arthropod vector and in the mammalian host. In recent years new findings provided answers to the role of TRAP proteins and in some cases the function of these adhesins during the parasite’s life cycle was redefined. In this review we will discuss the current knowledge of the diverse roles of the TRAP superfamily in vector-borne parasites from Class Aconoidasida. We will focus on the varied approaches that allowed the understanding of protein function and the relevance of TRAP- superfamily throughout the entire parasite’s cell cycle. |
| format | Artículo |
| id | INTA11838 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | Frontiers Media |
| publisherStr | Frontiers Media |
| record_format | dspace |
| spelling | INTA118382022-05-09T14:35:38Z Thrombospondin related anonymous protein superfamily in vector-borne apicomplexans: the parasite’s toolkit for cell invasion Paoletta, Martina Wilkowsky, Silvina Elizabeth Plasmodium Babesia Enfermedades Transmitidas Vectores Parásitos Sporozoa Vector-borne Diseases Parasites Apicomplexa Trombospondina Thrombospondin Apicomplexan parasites transmitted by vectors, including Babesia spp. and Plasmodium spp., cause severe disease in both humans and animals. These parasites have a complex life cycle during which they migrate, invade, and replicate in contrasting hosts such as the mammal and the invertebrate vector. The interaction of parasites with the host cell is mediated by adhesive proteins which play a key role in the different cellular processes regarding successful progression of the life cycle. Thrombospondin related anonymous protein (TRAP) is a superfamily of adhesins that are involved in motility, invasion and egress of the parasite. These proteins are stored and released from apical organelles and have either one or two types of adhesive domains, namely thrombospondin type 1 repeat and von Willebrand factor type A, that upon secretion are located in the extracellular portion of the molecule. Proteins from the TRAP superfamily have been intensively studied in Plasmodium species and to a lesser extent in Babesia spp., where they have proven to be functionally relevant throughout the entire parasite’s journey both in the arthropod vector and in the mammalian host. In recent years new findings provided answers to the role of TRAP proteins and in some cases the function of these adhesins during the parasite’s life cycle was redefined. In this review we will discuss the current knowledge of the diverse roles of the TRAP superfamily in vector-borne parasites from Class Aconoidasida. We will focus on the varied approaches that allowed the understanding of protein function and the relevance of TRAP- superfamily throughout the entire parasite’s cell cycle. Instituto de Biotecnología Fil: Paoletta, Martina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina Fil: Paoletta, Martina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Wilkowsky, Silvina Elizabeth. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina Fil: Wilkowsky, Silvina Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina 2022-05-09T14:29:09Z 2022-05-09T14:29:09Z 2022-04 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/11838 https://www.frontiersin.org/articles/10.3389/fcimb.2022.831592/full 2235-2988 https://doi.org/10.3389/fcimb.2022.831592 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Frontiers Media Frontiers in Cellular and Infection Microbiology 12 : 831592 (April 2022) |
| spellingShingle | Plasmodium Babesia Enfermedades Transmitidas Vectores Parásitos Sporozoa Vector-borne Diseases Parasites Apicomplexa Trombospondina Thrombospondin Paoletta, Martina Wilkowsky, Silvina Elizabeth Thrombospondin related anonymous protein superfamily in vector-borne apicomplexans: the parasite’s toolkit for cell invasion |
| title | Thrombospondin related anonymous protein superfamily in vector-borne apicomplexans: the parasite’s toolkit for cell invasion |
| title_full | Thrombospondin related anonymous protein superfamily in vector-borne apicomplexans: the parasite’s toolkit for cell invasion |
| title_fullStr | Thrombospondin related anonymous protein superfamily in vector-borne apicomplexans: the parasite’s toolkit for cell invasion |
| title_full_unstemmed | Thrombospondin related anonymous protein superfamily in vector-borne apicomplexans: the parasite’s toolkit for cell invasion |
| title_short | Thrombospondin related anonymous protein superfamily in vector-borne apicomplexans: the parasite’s toolkit for cell invasion |
| title_sort | thrombospondin related anonymous protein superfamily in vector borne apicomplexans the parasite s toolkit for cell invasion |
| topic | Plasmodium Babesia Enfermedades Transmitidas Vectores Parásitos Sporozoa Vector-borne Diseases Parasites Apicomplexa Trombospondina Thrombospondin |
| url | http://hdl.handle.net/20.500.12123/11838 https://www.frontiersin.org/articles/10.3389/fcimb.2022.831592/full https://doi.org/10.3389/fcimb.2022.831592 |
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