Pathogenesis of domestic pigs submitted to mycobacterial sensitizations previous to experimental infection with Mycobacterium bovis
Aim of study: To demonstrate the virulence of a Mycobacterium bovis local pig isolate in order to contribute to a better understanding of the pathological and immunological consequences of M. bovis infection in previous sensitized animals. Area of study: Buenos Aires, Argentina Material and me...
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| Format: | info:ar-repo/semantics/artículo |
| Language: | Inglés |
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INIA (España)
2022
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| Online Access: | http://hdl.handle.net/20.500.12123/11593 https://revistas.inia.es/index.php/sjar/article/view/18479 https://doi.org/10.5424/sjar/2022201-18479 |
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| author | Cuerda, Maria Ximena Colombatti Olivieri, Maria Alejandra Gravisaco, María José Marfil, Maria Jimena Barandiaran, Soledad Sevilla, Iker A. Garrido, Joseba M. Moyano, Roberto Damian Zumarraga, Martin Jose Romano, Maria Isabel Juste, Ramón A. Santangelo, María De La Paz |
| author_browse | Barandiaran, Soledad Colombatti Olivieri, Maria Alejandra Cuerda, Maria Ximena Garrido, Joseba M. Gravisaco, María José Juste, Ramón A. Marfil, Maria Jimena Moyano, Roberto Damian Romano, Maria Isabel Santangelo, María De La Paz Sevilla, Iker A. Zumarraga, Martin Jose |
| author_facet | Cuerda, Maria Ximena Colombatti Olivieri, Maria Alejandra Gravisaco, María José Marfil, Maria Jimena Barandiaran, Soledad Sevilla, Iker A. Garrido, Joseba M. Moyano, Roberto Damian Zumarraga, Martin Jose Romano, Maria Isabel Juste, Ramón A. Santangelo, María De La Paz |
| author_sort | Cuerda, Maria Ximena |
| collection | INTA Digital |
| description | Aim of study: To demonstrate the virulence of a Mycobacterium bovis local pig isolate in order to contribute to a better understanding of the pathological and immunological consequences of M. bovis infection in previous sensitized animals.
Area of study: Buenos Aires, Argentina
Material and methods: One group of ten pigs received two oral doses of killed M. bovis suspension and a comparative intradermal tuberculin test (CIT) (multiple sensitized) and then was infected with the M. bovis strain. Another group only received the CIT (single sensitized) and the infective dose. Humoral immune response was followed monthly, and gross pathology, histopathological and bacteriological analysis were performed at necropsy 100 days after infection.
Main results: M. bovis oral infection induced lesions and allowed bacterial growth in most of the animals. Previous sensitization with killed M. bovis suspension slightly raised the intensity of the response, as the multiple sensitized group showed higher lesion scores and humoral response.
Research highlights: Although the differences in lesion scores were not statistically significant, oral route infection after sensitization can modify the course of infections towards a fast development of lesions with a higher fibrotic component suggestive of increased resistance to infection in the right conditions. |
| format | info:ar-repo/semantics/artículo |
| id | INTA11593 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | INIA (España) |
| publisherStr | INIA (España) |
| record_format | dspace |
| spelling | INTA115932022-04-08T10:43:46Z Pathogenesis of domestic pigs submitted to mycobacterial sensitizations previous to experimental infection with Mycobacterium bovis Cuerda, Maria Ximena Colombatti Olivieri, Maria Alejandra Gravisaco, María José Marfil, Maria Jimena Barandiaran, Soledad Sevilla, Iker A. Garrido, Joseba M. Moyano, Roberto Damian Zumarraga, Martin Jose Romano, Maria Isabel Juste, Ramón A. Santangelo, María De La Paz Pathogenesis Swine Tuberculosis Histopathology Infectious Diseases Patogénesis Cerdo Mycobacterium bovis Histopatología Enfermedades Infecciosas Aim of study: To demonstrate the virulence of a Mycobacterium bovis local pig isolate in order to contribute to a better understanding of the pathological and immunological consequences of M. bovis infection in previous sensitized animals. Area of study: Buenos Aires, Argentina Material and methods: One group of ten pigs received two oral doses of killed M. bovis suspension and a comparative intradermal tuberculin test (CIT) (multiple sensitized) and then was infected with the M. bovis strain. Another group only received the CIT (single sensitized) and the infective dose. Humoral immune response was followed monthly, and gross pathology, histopathological and bacteriological analysis were performed at necropsy 100 days after infection. Main results: M. bovis oral infection induced lesions and allowed bacterial growth in most of the animals. Previous sensitization with killed M. bovis suspension slightly raised the intensity of the response, as the multiple sensitized group showed higher lesion scores and humoral response. Research highlights: Although the differences in lesion scores were not statistically significant, oral route infection after sensitization can modify the course of infections towards a fast development of lesions with a higher fibrotic component suggestive of increased resistance to infection in the right conditions. Instituto de Biotecnología Fil: Cuerda, Maria Ximena. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina Fil: Cuerda, Maria Ximena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Colombatti Olivieri, Maria Alejandra. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina Fil: Colombatti Olivieri, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Gravisaco, María José. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina Fil: Gravisaco, María José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Marfil, Maria Jimena. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina Fil: Barandiaran, Soledad. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina Fil: Sevilla, Iker A. Instituto Vasco de Investigación y Desarrollo Agrario (NEIKER). Departamento de Salud Animal; España Fil: Garrido, Joseba M. Instituto Vasco de Investigación y Desarrollo Agrario (NEIKER). Departamento de Salud Animal; España Fil: Moyano, Roberto Damian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina Fil: Moyano, Roberto Damian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Zumarraga, Martin Jose. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina Fil: Zumarraga, Martin Jose. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Romano, Maria Isabel. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina Fil: Romano, Maria Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Juste, Ramón A. Instituto Vasco de Investigación y Desarrollo Agrario (NEIKER). Departamento de Salud Animal; España Fil: Santangelo, María De La Paz. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina Fil: Santangelo, María De La Paz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina 2022-04-08T10:37:45Z 2022-04-08T10:37:45Z 2022-03 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/11593 https://revistas.inia.es/index.php/sjar/article/view/18479 1695-971X https://doi.org/10.5424/sjar/2022201-18479 eng info:eu-repograntAgreement/INTA/PNBIO-1131034/AR./Inmunología molecular y genómica funcional aplicadas a interacciones patógeno hospedador de interés pecuario. info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf INIA (España) Spanish Journal of Agricultural Research 20 (1) : e0502 (Marzo 2022) |
| spellingShingle | Pathogenesis Swine Tuberculosis Histopathology Infectious Diseases Patogénesis Cerdo Mycobacterium bovis Histopatología Enfermedades Infecciosas Cuerda, Maria Ximena Colombatti Olivieri, Maria Alejandra Gravisaco, María José Marfil, Maria Jimena Barandiaran, Soledad Sevilla, Iker A. Garrido, Joseba M. Moyano, Roberto Damian Zumarraga, Martin Jose Romano, Maria Isabel Juste, Ramón A. Santangelo, María De La Paz Pathogenesis of domestic pigs submitted to mycobacterial sensitizations previous to experimental infection with Mycobacterium bovis |
| title | Pathogenesis of domestic pigs submitted to mycobacterial sensitizations previous to experimental infection with Mycobacterium bovis |
| title_full | Pathogenesis of domestic pigs submitted to mycobacterial sensitizations previous to experimental infection with Mycobacterium bovis |
| title_fullStr | Pathogenesis of domestic pigs submitted to mycobacterial sensitizations previous to experimental infection with Mycobacterium bovis |
| title_full_unstemmed | Pathogenesis of domestic pigs submitted to mycobacterial sensitizations previous to experimental infection with Mycobacterium bovis |
| title_short | Pathogenesis of domestic pigs submitted to mycobacterial sensitizations previous to experimental infection with Mycobacterium bovis |
| title_sort | pathogenesis of domestic pigs submitted to mycobacterial sensitizations previous to experimental infection with mycobacterium bovis |
| topic | Pathogenesis Swine Tuberculosis Histopathology Infectious Diseases Patogénesis Cerdo Mycobacterium bovis Histopatología Enfermedades Infecciosas |
| url | http://hdl.handle.net/20.500.12123/11593 https://revistas.inia.es/index.php/sjar/article/view/18479 https://doi.org/10.5424/sjar/2022201-18479 |
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