Epidemic abortions due to Neospora caninum infection in farmed red deer (Cervus elaphus)
This study describes for the first time an abortion outbreak caused by Neospora caninum in farmed red deer. During a 5-year period, farmed hinds, naturally mated, were regularly ultrasound monitored to detect reproductive losses over their gestation. During the 4 years previous to the outbreak, abor...
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| Format: | info:ar-repo/semantics/artículo |
| Language: | Inglés |
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Springer Nature
2022
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| Online Access: | http://hdl.handle.net/20.500.12123/11522 https://link.springer.com/article/10.1007/s00436-022-07488-6 https://doi.org/10.1007/s00436-022-07488-6 |
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| author | Soler, Juan Pablo Moré, Gastón Urtizbiria, Facundo Nahuel Hecker, Yanina Cirone, Karina Mariela Scioli, Maria Valeria Paolicchi, Fernando Fiorentino, María Andrea Louge Uriarte, Enrique Leopoldo Canton, German Jose Verna, Andrea Elizabeth Morrell, Eleonora Lidia Moore, Prando Dadin |
| author_browse | Canton, German Jose Cirone, Karina Mariela Fiorentino, María Andrea Hecker, Yanina Louge Uriarte, Enrique Leopoldo Moore, Prando Dadin Morrell, Eleonora Lidia Moré, Gastón Paolicchi, Fernando Scioli, Maria Valeria Soler, Juan Pablo Urtizbiria, Facundo Nahuel Verna, Andrea Elizabeth |
| author_facet | Soler, Juan Pablo Moré, Gastón Urtizbiria, Facundo Nahuel Hecker, Yanina Cirone, Karina Mariela Scioli, Maria Valeria Paolicchi, Fernando Fiorentino, María Andrea Louge Uriarte, Enrique Leopoldo Canton, German Jose Verna, Andrea Elizabeth Morrell, Eleonora Lidia Moore, Prando Dadin |
| author_sort | Soler, Juan Pablo |
| collection | INTA Digital |
| description | This study describes for the first time an abortion outbreak caused by Neospora caninum in farmed red deer. During a 5-year period, farmed hinds, naturally mated, were regularly ultrasound monitored to detect reproductive losses over their gestation. During the 4 years previous to the outbreak, abortion rates ranged from 4.7 to 8.6% (average 6.5%), and serology for indirect diagnosis of neosporosis and toxoplasmosis was performed. At the fifth year, the abortion rate increased to 25.3%. During this outbreak, three aborted foetuses and their placentas were recovered and submitted to laboratory for etiological diagnosis. Blood samples were collected from the 81 hinds at the end of the gestational period and the seropositivity rate for N. caninum, Toxoplasma gondii, Brucella abortus, bovine viral diarrhoea virus and bovine alphaherpesvirus type 1 was 66.7%, 67.9%, 0.0%, 8.6% and 0.0%, respectively. Neospora caninum-seropositive hinds (OR = 5.7, P = 0.0271) and hinds with high antibody titres to N. caninum (OR = 7.4, P = 0.0130) were more likely to abort than seronegative hinds. In addition, N. caninum seropositivity rate in the aborted hinds was higher (OR = 5.4, P = 0.033) than the non-aborted hinds. No association was found between T. gondii nor BVDV-seropositivity and abortions. Typical protozoal histopathologic findings (necrotizing non suppurative encephalitis, meningitis, myocarditis, hepatitis, among others) were observed in all foetuses. Neospora caninum was immunolabelled by immunohistochemistry in several tissues from two foetuses, and infection was also confirmed in the three foetuses by serology and/or DNA detection. No other abortifacient agent was detected in the foetuses. Their dams showed high N. caninum antibody titres (≥ 6400). Serologic evidence and epidemiological data recorded suggested a point-source of N. caninum infection before the occurrence of the outbreak, probably related with contaminated feedstuff with oocysts. Moreover, the intensive production system with a high stocking rate could be also considered a factor which might have increased the risk of horizontal N. caninum infection in this herd. |
| format | info:ar-repo/semantics/artículo |
| id | INTA11522 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | Springer Nature |
| publisherStr | Springer Nature |
| record_format | dspace |
| spelling | INTA115222022-03-31T17:17:13Z Epidemic abortions due to Neospora caninum infection in farmed red deer (Cervus elaphus) Soler, Juan Pablo Moré, Gastón Urtizbiria, Facundo Nahuel Hecker, Yanina Cirone, Karina Mariela Scioli, Maria Valeria Paolicchi, Fernando Fiorentino, María Andrea Louge Uriarte, Enrique Leopoldo Canton, German Jose Verna, Andrea Elizabeth Morrell, Eleonora Lidia Moore, Prando Dadin Neospora Caninum Neosporosis Aborto Cervus Elaphus Abortion Ciervo Rojo Pérdidas Reproductivas This study describes for the first time an abortion outbreak caused by Neospora caninum in farmed red deer. During a 5-year period, farmed hinds, naturally mated, were regularly ultrasound monitored to detect reproductive losses over their gestation. During the 4 years previous to the outbreak, abortion rates ranged from 4.7 to 8.6% (average 6.5%), and serology for indirect diagnosis of neosporosis and toxoplasmosis was performed. At the fifth year, the abortion rate increased to 25.3%. During this outbreak, three aborted foetuses and their placentas were recovered and submitted to laboratory for etiological diagnosis. Blood samples were collected from the 81 hinds at the end of the gestational period and the seropositivity rate for N. caninum, Toxoplasma gondii, Brucella abortus, bovine viral diarrhoea virus and bovine alphaherpesvirus type 1 was 66.7%, 67.9%, 0.0%, 8.6% and 0.0%, respectively. Neospora caninum-seropositive hinds (OR = 5.7, P = 0.0271) and hinds with high antibody titres to N. caninum (OR = 7.4, P = 0.0130) were more likely to abort than seronegative hinds. In addition, N. caninum seropositivity rate in the aborted hinds was higher (OR = 5.4, P = 0.033) than the non-aborted hinds. No association was found between T. gondii nor BVDV-seropositivity and abortions. Typical protozoal histopathologic findings (necrotizing non suppurative encephalitis, meningitis, myocarditis, hepatitis, among others) were observed in all foetuses. Neospora caninum was immunolabelled by immunohistochemistry in several tissues from two foetuses, and infection was also confirmed in the three foetuses by serology and/or DNA detection. No other abortifacient agent was detected in the foetuses. Their dams showed high N. caninum antibody titres (≥ 6400). Serologic evidence and epidemiological data recorded suggested a point-source of N. caninum infection before the occurrence of the outbreak, probably related with contaminated feedstuff with oocysts. Moreover, the intensive production system with a high stocking rate could be also considered a factor which might have increased the risk of horizontal N. caninum infection in this herd. EEA Balcarce Fil: Soler, Juan Pablo. Servicio Veterinario CERVUS; Argentina. Fil: Moré, Gastón. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Laboratorio de Inmunoparasitología; Argentina. Fil: Moré, Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fil: Urtizbiría, Facundo Nahuel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina. Fil: Hecker, Yanina Paola. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fil: Cirone, Karina Mariela. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina. Fil: Cirone, Karina Mariela. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina. Fil: Scioli, María Valeria. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina. Fil: Paolicchi, Fernando Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina. Fil: Paolicchi, Fernando Alberto. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina. Fil: Fiorentino, María Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina. Fil: Fiorentino, María Andrea. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina. Fil: Louge Uriarte, Enrique Leopoldo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina. Fil: Cantón, Germán José. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina. Fil: Verna, Andrea Elizabeth. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina. Fil: Verna, Andrea Elizabeth. Consejo Nacional de Investigaciones Científicas Y Técnicas; Argentina. Fil: Morrell, Eleonora Lidia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina. Fil: Moore, Dadin Prando. Consejo Nacional de Investigaciones Científicas Y Técnicas; Argentina. Fil: Moore, Dadin Prando. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina. 2022-03-31T17:09:19Z 2022-03-31T17:09:19Z 2022-03-19 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/11522 https://link.springer.com/article/10.1007/s00436-022-07488-6 0932-0113 (print) 1432-1955 (online) https://doi.org/10.1007/s00436-022-07488-6 eng info:eu-repo/semantics/restrictedAccess application/pdf Springer Nature Parasitology Research (Published: 19 March 2022) |
| spellingShingle | Neospora Caninum Neosporosis Aborto Cervus Elaphus Abortion Ciervo Rojo Pérdidas Reproductivas Soler, Juan Pablo Moré, Gastón Urtizbiria, Facundo Nahuel Hecker, Yanina Cirone, Karina Mariela Scioli, Maria Valeria Paolicchi, Fernando Fiorentino, María Andrea Louge Uriarte, Enrique Leopoldo Canton, German Jose Verna, Andrea Elizabeth Morrell, Eleonora Lidia Moore, Prando Dadin Epidemic abortions due to Neospora caninum infection in farmed red deer (Cervus elaphus) |
| title | Epidemic abortions due to Neospora caninum infection in farmed red deer (Cervus elaphus) |
| title_full | Epidemic abortions due to Neospora caninum infection in farmed red deer (Cervus elaphus) |
| title_fullStr | Epidemic abortions due to Neospora caninum infection in farmed red deer (Cervus elaphus) |
| title_full_unstemmed | Epidemic abortions due to Neospora caninum infection in farmed red deer (Cervus elaphus) |
| title_short | Epidemic abortions due to Neospora caninum infection in farmed red deer (Cervus elaphus) |
| title_sort | epidemic abortions due to neospora caninum infection in farmed red deer cervus elaphus |
| topic | Neospora Caninum Neosporosis Aborto Cervus Elaphus Abortion Ciervo Rojo Pérdidas Reproductivas |
| url | http://hdl.handle.net/20.500.12123/11522 https://link.springer.com/article/10.1007/s00436-022-07488-6 https://doi.org/10.1007/s00436-022-07488-6 |
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