Iatrogenic doramectin overdosing causes toxicity in sheep: a case report
Macrocyclic lactones are widely used endectocides in ruminants, with a high margin of safety for labeled indications. No previous report of iatrogenic doramectin overdosing has been published. We report an outbreak in a sheep flock in Northeast Patagonia, Argentina. Toxicity signs were observed in m...
| Autores principales: | , , , , , |
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| Formato: | info:ar-repo/semantics/artículo |
| Lenguaje: | Inglés |
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Elsevier
2022
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/11521 https://www.sciencedirect.com/science/article/pii/S2405939022000387 https://doi.org/10.1016/j.vprsr.2022.100722 |
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| author | Canton, German Jose Urtizbiria, Facundo Nahuel Lloberas, María Mercedes Morrell, Eleonora Lidia Lanusse, Carlos Edmundo Lifschitz, Adrian Luis |
| author_browse | Canton, German Jose Lanusse, Carlos Edmundo Lifschitz, Adrian Luis Lloberas, María Mercedes Morrell, Eleonora Lidia Urtizbiria, Facundo Nahuel |
| author_facet | Canton, German Jose Urtizbiria, Facundo Nahuel Lloberas, María Mercedes Morrell, Eleonora Lidia Lanusse, Carlos Edmundo Lifschitz, Adrian Luis |
| author_sort | Canton, German Jose |
| collection | INTA Digital |
| description | Macrocyclic lactones are widely used endectocides in ruminants, with a high margin of safety for labeled indications. No previous report of iatrogenic doramectin overdosing has been published. We report an outbreak in a sheep flock in Northeast Patagonia, Argentina. Toxicity signs were observed in more than 10% and 59% of ewes and lambs, respectively, particularly those with low body condition, treated with doramectin 3.5% long-acting injectable formulation, presumably at the indicated dose of 700 μg/kg. Clinical signs included lethargy, mydriasis and coma. Doramectin concentration in blood samples was 826.8 (±119.3) ng/ml. Cerebrospinal fluid (CSF) and liver doramectin concentration in euthanized lambs were 3.26–4.28 ng/ml and 8506–8772 ng/g, respectively. Epidemiological and clinical information, and high doramectin concentration were sufficient to confirm the neurotoxicity. Scarce fat deposition could have altered doramectin pharmacokinetic which may have accounted for the observed neurotoxicity. Special care should be taken when animals under similar nutritional conditions are treated with macrocyclic lactones. |
| format | info:ar-repo/semantics/artículo |
| id | INTA11521 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | INTA115212022-11-04T14:18:43Z Iatrogenic doramectin overdosing causes toxicity in sheep: a case report Canton, German Jose Urtizbiria, Facundo Nahuel Lloberas, María Mercedes Morrell, Eleonora Lidia Lanusse, Carlos Edmundo Lifschitz, Adrian Luis Lactonas Toxicidad Rumiante Ovinos Lactones Toxicity Ruminants Sheep Iatrogénico Macrocyclic lactones are widely used endectocides in ruminants, with a high margin of safety for labeled indications. No previous report of iatrogenic doramectin overdosing has been published. We report an outbreak in a sheep flock in Northeast Patagonia, Argentina. Toxicity signs were observed in more than 10% and 59% of ewes and lambs, respectively, particularly those with low body condition, treated with doramectin 3.5% long-acting injectable formulation, presumably at the indicated dose of 700 μg/kg. Clinical signs included lethargy, mydriasis and coma. Doramectin concentration in blood samples was 826.8 (±119.3) ng/ml. Cerebrospinal fluid (CSF) and liver doramectin concentration in euthanized lambs were 3.26–4.28 ng/ml and 8506–8772 ng/g, respectively. Epidemiological and clinical information, and high doramectin concentration were sufficient to confirm the neurotoxicity. Scarce fat deposition could have altered doramectin pharmacokinetic which may have accounted for the observed neurotoxicity. Special care should be taken when animals under similar nutritional conditions are treated with macrocyclic lactones. EEA Balcarce Fil: Cantón, Germán José. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina. Fil: Urtizbiría, Facundo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina. Fil: Lloberas, María Mercedes. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina. Fil: Morrell, Eleonora. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina. Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina. Fil: Lifschitz, Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina. 2022-03-31T17:01:07Z 2022-03-31T17:01:07Z 2022-03-24 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/11521 https://www.sciencedirect.com/science/article/pii/S2405939022000387 2405-9390 https://doi.org/10.1016/j.vprsr.2022.100722 eng info:eu-repograntAgreement/INTA/2019-RIST-E5-I111-001/2019-RIST-E5-I111-001/AR./Laboratorios de Diagnóstico Veterinario info:eu-repo/semantics/restrictedAccess application/pdf Elsevier Veterinary Parasitology: Regional Studies and Reports 30 : 100722 (May 2022) |
| spellingShingle | Lactonas Toxicidad Rumiante Ovinos Lactones Toxicity Ruminants Sheep Iatrogénico Canton, German Jose Urtizbiria, Facundo Nahuel Lloberas, María Mercedes Morrell, Eleonora Lidia Lanusse, Carlos Edmundo Lifschitz, Adrian Luis Iatrogenic doramectin overdosing causes toxicity in sheep: a case report |
| title | Iatrogenic doramectin overdosing causes toxicity in sheep: a case report |
| title_full | Iatrogenic doramectin overdosing causes toxicity in sheep: a case report |
| title_fullStr | Iatrogenic doramectin overdosing causes toxicity in sheep: a case report |
| title_full_unstemmed | Iatrogenic doramectin overdosing causes toxicity in sheep: a case report |
| title_short | Iatrogenic doramectin overdosing causes toxicity in sheep: a case report |
| title_sort | iatrogenic doramectin overdosing causes toxicity in sheep a case report |
| topic | Lactonas Toxicidad Rumiante Ovinos Lactones Toxicity Ruminants Sheep Iatrogénico |
| url | http://hdl.handle.net/20.500.12123/11521 https://www.sciencedirect.com/science/article/pii/S2405939022000387 https://doi.org/10.1016/j.vprsr.2022.100722 |
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