First report of in vitro resistance of Psoroptes ovis to ivermectin in Argentina
Sheep scab, or psoroptic mange, a disease caused by the mite Psoroptes ovis, is commonly treated with ivermectin (IVM) and other macrocyclic lactones. In Argentina, in vivo trials have shown a decrease in IVM effectiveness to treat both sheep and bovine scab. In this work, we used an in vitro techni...
| Autores principales: | , , |
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| Formato: | info:ar-repo/semantics/artículo |
| Lenguaje: | Inglés |
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Elsevier
2022
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/11410 https://www.sciencedirect.com/science/article/abs/pii/S0014489422000236 https://doi.org/10.1016/j.exppara.2022.108229 |
| _version_ | 1855036568537923584 |
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| author | Soler, Paula Germano, Monica Daniela Larroza, Marcela Patricia |
| author_browse | Germano, Monica Daniela Larroza, Marcela Patricia Soler, Paula |
| author_facet | Soler, Paula Germano, Monica Daniela Larroza, Marcela Patricia |
| author_sort | Soler, Paula |
| collection | INTA Digital |
| description | Sheep scab, or psoroptic mange, a disease caused by the mite Psoroptes ovis, is commonly treated with ivermectin (IVM) and other macrocyclic lactones. In Argentina, in vivo trials have shown a decrease in IVM effectiveness to treat both sheep and bovine scab. In this work, we used an in vitro technique to establish the efficacy of IVM and two other macrocyclic lactones, doramectin (DRM) and moxidectin (MXD), against P. ovis in sheep. Mites were exposed to plates with culture medium and either ethanol or each of the acaricides, and mite mortality at a diagnostic concentration of IVM was assessed. Total survival in one of the strains studied demonstrated the presence of resistance, associated with control failures previously described by the authors. These resistant mites
also presented larger LC50 values for both DRM and MXD than expected. Since, in in vivo trials, we had also previously observed a decrease in DRM effectiveness, cross-resistance may exist between DRM and IVM. We propose the use of in vitro tests to evaluate the efficacy of acaricides, considering their practicality, low cost and proven usefulness in detecting resistance in cases of low effectiveness against sheep scab |
| format | info:ar-repo/semantics/artículo |
| id | INTA11410 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | INTA114102022-03-15T21:37:25Z First report of in vitro resistance of Psoroptes ovis to ivermectin in Argentina Soler, Paula Germano, Monica Daniela Larroza, Marcela Patricia Sanidad Animal Sarna Sarna Psoróptica Enfermedades Parasitarias Ivermectina Animal Health Mange Psoroptic Mange Parasitoses Ivermectin Sheep scab, or psoroptic mange, a disease caused by the mite Psoroptes ovis, is commonly treated with ivermectin (IVM) and other macrocyclic lactones. In Argentina, in vivo trials have shown a decrease in IVM effectiveness to treat both sheep and bovine scab. In this work, we used an in vitro technique to establish the efficacy of IVM and two other macrocyclic lactones, doramectin (DRM) and moxidectin (MXD), against P. ovis in sheep. Mites were exposed to plates with culture medium and either ethanol or each of the acaricides, and mite mortality at a diagnostic concentration of IVM was assessed. Total survival in one of the strains studied demonstrated the presence of resistance, associated with control failures previously described by the authors. These resistant mites also presented larger LC50 values for both DRM and MXD than expected. Since, in in vivo trials, we had also previously observed a decrease in DRM effectiveness, cross-resistance may exist between DRM and IVM. We propose the use of in vitro tests to evaluate the efficacy of acaricides, considering their practicality, low cost and proven usefulness in detecting resistance in cases of low effectiveness against sheep scab Estación Experimental Agropecuaria Bariloche Fil: Soler, Paula. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Area de Produccion Animal. Grupo de Sanidad Animal; Argentina Fil: Germano, Monica Daniela. Instituto Nacional de Tecnologia Agropecuaria (INTA). Estacion Experimental Agropecuaria Bariloche; Argentina Fil: Germano, Monica Daniela. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Investigaciones Forestales y Agropecuarias Bariloche; Argentina Fil: Larroza, Marcela Patricia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Area de Produccion Animal. Grupo de Sanidad Animal; Argentina 2022-03-15T21:31:38Z 2022-03-15T21:31:38Z 2022-04 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/11410 https://www.sciencedirect.com/science/article/abs/pii/S0014489422000236 0014-4894 https://doi.org/10.1016/j.exppara.2022.108229 eng info:eu-repograntAgreement/INTA/2019-PD-E5-I104-001/2019-PD-E5-I104-001/AR./Estudios sobre generación de resistencia a los antimicrobianos y desarrollo de alternativas profilácticas y terapéuticas info:eu-repograntAgreement/INTA/2019-PE-E1-I002-001/2019-PE-E1-I002-001/AR./Tecnologías sostenibles para la estabilización y mejora de la competitividad de las cadenas productivas de ovinos, caprinos y camélidos sudamericanos. info:eu-repo/semantics/restrictedAccess application/pdf Elsevier Experimental Parasitology 235 : Art. 108229 (Abril 2022) |
| spellingShingle | Sanidad Animal Sarna Sarna Psoróptica Enfermedades Parasitarias Ivermectina Animal Health Mange Psoroptic Mange Parasitoses Ivermectin Soler, Paula Germano, Monica Daniela Larroza, Marcela Patricia First report of in vitro resistance of Psoroptes ovis to ivermectin in Argentina |
| title | First report of in vitro resistance of Psoroptes ovis to ivermectin in Argentina |
| title_full | First report of in vitro resistance of Psoroptes ovis to ivermectin in Argentina |
| title_fullStr | First report of in vitro resistance of Psoroptes ovis to ivermectin in Argentina |
| title_full_unstemmed | First report of in vitro resistance of Psoroptes ovis to ivermectin in Argentina |
| title_short | First report of in vitro resistance of Psoroptes ovis to ivermectin in Argentina |
| title_sort | first report of in vitro resistance of psoroptes ovis to ivermectin in argentina |
| topic | Sanidad Animal Sarna Sarna Psoróptica Enfermedades Parasitarias Ivermectina Animal Health Mange Psoroptic Mange Parasitoses Ivermectin |
| url | http://hdl.handle.net/20.500.12123/11410 https://www.sciencedirect.com/science/article/abs/pii/S0014489422000236 https://doi.org/10.1016/j.exppara.2022.108229 |
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