Epidemiology of Pig Tuberculosis in Argentina
Bovine tuberculosis (bTB) is a disease caused mainly by the Mycobacterium bovis and that is endemic to livestock populations in most Latin American countries. Traditionally, bTB control programs are costly and targeted to cattle, largely disregarding other species such as swine and wildlife. Accordi...
| Main Authors: | , , , , , , , , , , |
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| Format: | Artículo |
| Language: | Inglés |
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Frontiers Editorial
2022
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.12123/11129 https://www.frontiersin.org/articles/10.3389/fvets.2021.693082/full https://doi.org/10.3389/fvets.2021.693082 |
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| author | Barandiaran, Soledad Marfil, Maria Jimena Capobianco, Guillermo Perez Aguirreburualde, María Sol Zumarraga, Martin Jose Eirin, Maria Emilia Cuerda, Maria Ximena Winter, Marina Martinez Vivot, Marcela Pérez, Andrés Maximiliano La Sala, Luciano Francisco |
| author_browse | Barandiaran, Soledad Capobianco, Guillermo Cuerda, Maria Ximena Eirin, Maria Emilia La Sala, Luciano Francisco Marfil, Maria Jimena Martinez Vivot, Marcela Perez Aguirreburualde, María Sol Pérez, Andrés Maximiliano Winter, Marina Zumarraga, Martin Jose |
| author_facet | Barandiaran, Soledad Marfil, Maria Jimena Capobianco, Guillermo Perez Aguirreburualde, María Sol Zumarraga, Martin Jose Eirin, Maria Emilia Cuerda, Maria Ximena Winter, Marina Martinez Vivot, Marcela Pérez, Andrés Maximiliano La Sala, Luciano Francisco |
| author_sort | Barandiaran, Soledad |
| collection | INTA Digital |
| description | Bovine tuberculosis (bTB) is a disease caused mainly by the Mycobacterium bovis and that is endemic to livestock populations in most Latin American countries. Traditionally, bTB control programs are costly and targeted to cattle, largely disregarding other species such as swine and wildlife. According to official services, in Argentina disease prevalence in pigs is comparable to that observed in cattle, suggesting the need for efficient control programs to manage the disease in both species. Additionally, extensive farming systems, which are commonly practiced in Argentina, allow the interaction between livestock and wildlife such as wild boar (Sus scrofa), which is considered a natural host of the disease. Here, we evaluated the bTB pigs- cattle interface, studying the dynamics of M. bovis isolates in the pig population and identifying farm-level epidemiological variables associated with the disease confirmation at slaughterhouses. Additionally, to assess the potential multi-host systems in the transmission of bTB, the molecular characterization of wild boar mycobacterial strains was included in the study, as this interaction has not been previously evaluated in this region. Multivariable logistic regression models were used to assess the association between farm-level epidemiological variables (location, farm size, and co-existence with cattle and goats) and bTB confirmation in pig tuberculosis-like lesions samples. Results showed that when cattle were present, the odds of bTB in pigs decreased 0.3 or 0.6% for every additional sow when cattle were present or absent in the farm, respectively. Pigs shared 60% (18/30) of the genotypes with cattle and wild boar, suggesting transmission at the interface between pigs and cattle and highlighting the potential role of wild boar in bTB maintenance. These results provide novel information about the molecular diversity of M. bovis strains in pigs in Argentina and proposes the potential relevance of a multi-host system in the epidemiology of bTB in the region. The statistical models presented here may be used in the design of a low cost, abattoir-based surveillance program for bTB in the pig industry in Argentina, with potential extension to other settings with similar epidemiological conditions. |
| format | Artículo |
| id | INTA11129 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | Frontiers Editorial |
| publisherStr | Frontiers Editorial |
| record_format | dspace |
| spelling | INTA111292022-01-14T15:24:31Z Epidemiology of Pig Tuberculosis in Argentina Barandiaran, Soledad Marfil, Maria Jimena Capobianco, Guillermo Perez Aguirreburualde, María Sol Zumarraga, Martin Jose Eirin, Maria Emilia Cuerda, Maria Ximena Winter, Marina Martinez Vivot, Marcela Pérez, Andrés Maximiliano La Sala, Luciano Francisco Enfermedades de los Animales Cerdo Epidemiología Argentina Animal Diseases Tuberculosis Swine Epidemiology Bovine tuberculosis (bTB) is a disease caused mainly by the Mycobacterium bovis and that is endemic to livestock populations in most Latin American countries. Traditionally, bTB control programs are costly and targeted to cattle, largely disregarding other species such as swine and wildlife. According to official services, in Argentina disease prevalence in pigs is comparable to that observed in cattle, suggesting the need for efficient control programs to manage the disease in both species. Additionally, extensive farming systems, which are commonly practiced in Argentina, allow the interaction between livestock and wildlife such as wild boar (Sus scrofa), which is considered a natural host of the disease. Here, we evaluated the bTB pigs- cattle interface, studying the dynamics of M. bovis isolates in the pig population and identifying farm-level epidemiological variables associated with the disease confirmation at slaughterhouses. Additionally, to assess the potential multi-host systems in the transmission of bTB, the molecular characterization of wild boar mycobacterial strains was included in the study, as this interaction has not been previously evaluated in this region. Multivariable logistic regression models were used to assess the association between farm-level epidemiological variables (location, farm size, and co-existence with cattle and goats) and bTB confirmation in pig tuberculosis-like lesions samples. Results showed that when cattle were present, the odds of bTB in pigs decreased 0.3 or 0.6% for every additional sow when cattle were present or absent in the farm, respectively. Pigs shared 60% (18/30) of the genotypes with cattle and wild boar, suggesting transmission at the interface between pigs and cattle and highlighting the potential role of wild boar in bTB maintenance. These results provide novel information about the molecular diversity of M. bovis strains in pigs in Argentina and proposes the potential relevance of a multi-host system in the epidemiology of bTB in the region. The statistical models presented here may be used in the design of a low cost, abattoir-based surveillance program for bTB in the pig industry in Argentina, with potential extension to other settings with similar epidemiological conditions. Instituto de Biotecnología Fil: Barandiaran, Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Producción Animal; Argentina Fil: Barandiaran, Soledad. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina Fil: Marfil, Maria Jimena. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Enfermedades Infecciosas; Argentina Fil: Capobianco, Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Matemática de Bahía Blanca; Argentina Fil: Capobianco, Guillermo. Universidad Nacional del Sur. Departamento de Matemática. Instituto de Matemática de Bahía Blanca; Argentina Fil: Perez Aguirreburualde, María Sol. University of Minnesota. College of Veterinary Medicine; Estados Unidos Fil: Zumarraga, Martin Jose. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina Fil: Zumarraga, Martin Jose. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Eirin, Maria Emilia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina Fil: Eirin, Maria Emilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Cuerda, Maria Ximena. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina Fil: Cuerda, Maria Ximena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Winter, Marina. Universidad Nacional de Río Negro. Centro de Investigaciones y Transferencia de Río Negro; Argentina Fil: Martinez Vivot, Marcela. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Enfermedades Infecciosas; Argentina Fil: Pérez, Andrés Maximiliano. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina Fil: Pérez, Andrés Maximiliano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: La Sala, Luciano Francisco. Universidad Nacional del Sur. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina Fil: La Sala, Luciano Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina 2022-01-14T15:21:20Z 2022-01-14T15:21:20Z 2021-07 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/11129 https://www.frontiersin.org/articles/10.3389/fvets.2021.693082/full 2297-1769 https://doi.org/10.3389/fvets.2021.693082 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Frontiers Editorial Frontiers in Veterinary Science 8 : 693082 (July 2021) |
| spellingShingle | Enfermedades de los Animales Cerdo Epidemiología Argentina Animal Diseases Tuberculosis Swine Epidemiology Barandiaran, Soledad Marfil, Maria Jimena Capobianco, Guillermo Perez Aguirreburualde, María Sol Zumarraga, Martin Jose Eirin, Maria Emilia Cuerda, Maria Ximena Winter, Marina Martinez Vivot, Marcela Pérez, Andrés Maximiliano La Sala, Luciano Francisco Epidemiology of Pig Tuberculosis in Argentina |
| title | Epidemiology of Pig Tuberculosis in Argentina |
| title_full | Epidemiology of Pig Tuberculosis in Argentina |
| title_fullStr | Epidemiology of Pig Tuberculosis in Argentina |
| title_full_unstemmed | Epidemiology of Pig Tuberculosis in Argentina |
| title_short | Epidemiology of Pig Tuberculosis in Argentina |
| title_sort | epidemiology of pig tuberculosis in argentina |
| topic | Enfermedades de los Animales Cerdo Epidemiología Argentina Animal Diseases Tuberculosis Swine Epidemiology |
| url | http://hdl.handle.net/20.500.12123/11129 https://www.frontiersin.org/articles/10.3389/fvets.2021.693082/full https://doi.org/10.3389/fvets.2021.693082 |
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