The subunit vaccine H65 + CAF01 increased the BCG- protection against Mycobacterium bovis infection in a mouse model of bovine tuberculosis
H65, a fusion protein of three pairs of ESX-secreted antigens of Mycobacterium tuberculosis and Mycobacterium bovis, formulated with the liposomal adjuvant CAF01 has been shown to confer protection against M. tuberculosis infection in mice. In this study, we evaluated the impact of combining BCG wit...
| Main Authors: | , , , |
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| Format: | Artículo |
| Language: | Inglés |
| Published: |
Elsevier
2021
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| Online Access: | http://hdl.handle.net/20.500.12123/10917 https://www.sciencedirect.com/science/article/abs/pii/S0034528821001132 https://doi.org/10.1016/j.rvsc.2021.04.014 |
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| author | Blanco, Federico Carlos Garcia, Elizabeth Andrea Aagaard, Claus Bigi, Fabiana |
| author_browse | Aagaard, Claus Bigi, Fabiana Blanco, Federico Carlos Garcia, Elizabeth Andrea |
| author_facet | Blanco, Federico Carlos Garcia, Elizabeth Andrea Aagaard, Claus Bigi, Fabiana |
| author_sort | Blanco, Federico Carlos |
| collection | INTA Digital |
| description | H65, a fusion protein of three pairs of ESX-secreted antigens of Mycobacterium tuberculosis and Mycobacterium bovis, formulated with the liposomal adjuvant CAF01 has been shown to confer protection against M. tuberculosis infection in mice. In this study, we evaluated the impact of combining BCG with H65 + CAF01 immunization in a M. bovis mouse model of infection. We found that a BCG-H65 + CAF01/ H65 + CAF01 prime-boost scheme induced higher protection than BCG and H65 + CAF01 alone. Altogether, H65 antigen formulated in liposomal adjuvant improved the BCG-induced immune protection, thus making this vaccine strategy a promising tool to control bovine tuberculosis. |
| format | Artículo |
| id | INTA10917 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | INTA109172021-12-15T16:26:45Z The subunit vaccine H65 + CAF01 increased the BCG- protection against Mycobacterium bovis infection in a mouse model of bovine tuberculosis Blanco, Federico Carlos Garcia, Elizabeth Andrea Aagaard, Claus Bigi, Fabiana Mycobacterium bovis Vacuna Control de Enfermedades Infección por Mycobacterium Bovis Vaccines Disease Control Mycobacterium Bovis Infections Tuberculosis Bovina Bovine Tuberculosis H65, a fusion protein of three pairs of ESX-secreted antigens of Mycobacterium tuberculosis and Mycobacterium bovis, formulated with the liposomal adjuvant CAF01 has been shown to confer protection against M. tuberculosis infection in mice. In this study, we evaluated the impact of combining BCG with H65 + CAF01 immunization in a M. bovis mouse model of infection. We found that a BCG-H65 + CAF01/ H65 + CAF01 prime-boost scheme induced higher protection than BCG and H65 + CAF01 alone. Altogether, H65 antigen formulated in liposomal adjuvant improved the BCG-induced immune protection, thus making this vaccine strategy a promising tool to control bovine tuberculosis. Instituto de Biotecnología Fil: Blanco, Federico Carlos. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina Fil: Blanco, Federico Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Garcia, Elizabeth Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina Fil: Garcia, Elizabeth Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Aagaard, Claus. Statens Serum Institut. Department of Infectious Disease Immunology; Dinamarca Fil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina. Fil: Bigi, Fabiana. Consejo Nacional de investigaciones Científicas y Tecnológicas; Argentina 2021-12-15T16:23:28Z 2021-12-15T16:23:28Z 2021-05 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion http://hdl.handle.net/20.500.12123/10917 https://www.sciencedirect.com/science/article/abs/pii/S0034528821001132 0034-5288 https://doi.org/10.1016/j.rvsc.2021.04.014 eng info:eu-repograntAgreement/INTA/2019-PD-E5-I102-001/2019-PD-E5-I102-001/AR./Desarrollo de vacunas y tecnologías para mejorar las estrategias profilácticas y terapéuticas de las enfermedades que afectan la producción animal y la salud pública info:eu-repo/semantics/embargoedAccess application/pdf Elsevier Research in Veterinary Science 136 : 595-597 (May 2021) |
| spellingShingle | Mycobacterium bovis Vacuna Control de Enfermedades Infección por Mycobacterium Bovis Vaccines Disease Control Mycobacterium Bovis Infections Tuberculosis Bovina Bovine Tuberculosis Blanco, Federico Carlos Garcia, Elizabeth Andrea Aagaard, Claus Bigi, Fabiana The subunit vaccine H65 + CAF01 increased the BCG- protection against Mycobacterium bovis infection in a mouse model of bovine tuberculosis |
| title | The subunit vaccine H65 + CAF01 increased the BCG- protection against Mycobacterium bovis infection in a mouse model of bovine tuberculosis |
| title_full | The subunit vaccine H65 + CAF01 increased the BCG- protection against Mycobacterium bovis infection in a mouse model of bovine tuberculosis |
| title_fullStr | The subunit vaccine H65 + CAF01 increased the BCG- protection against Mycobacterium bovis infection in a mouse model of bovine tuberculosis |
| title_full_unstemmed | The subunit vaccine H65 + CAF01 increased the BCG- protection against Mycobacterium bovis infection in a mouse model of bovine tuberculosis |
| title_short | The subunit vaccine H65 + CAF01 increased the BCG- protection against Mycobacterium bovis infection in a mouse model of bovine tuberculosis |
| title_sort | subunit vaccine h65 caf01 increased the bcg protection against mycobacterium bovis infection in a mouse model of bovine tuberculosis |
| topic | Mycobacterium bovis Vacuna Control de Enfermedades Infección por Mycobacterium Bovis Vaccines Disease Control Mycobacterium Bovis Infections Tuberculosis Bovina Bovine Tuberculosis |
| url | http://hdl.handle.net/20.500.12123/10917 https://www.sciencedirect.com/science/article/abs/pii/S0034528821001132 https://doi.org/10.1016/j.rvsc.2021.04.014 |
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