Alpha-mannosidosis caused by toxic plants in ruminants of Argentina
It is well known that several of the swainsonine-containing plant species found widespread around the world have a negative economic impact in each country. In Argentina, most of the information on the poisonous plant species that produce α-mannosidosis is published in Spanish and thus not available...
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| Formato: | Artículo |
| Lenguaje: | Inglés |
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Academia Brasileira de Ciencias
2021
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12123/10720 https://www.scielo.br/j/aabc/a/phRKSPsNW73QJN8C7jWTjnL/?lang=en https://doi.org/10.1590/0001-3765202120191496 |
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| author | Cholich, Luciana Andrea Martinez, Agustin Micheloud, Juan Francisco Pistán, Maria Elena Garcia, Enrique Nicolas Robles, Carlos Alejandro Ortega, Hugo Hector Gimeno, Eduardo Juan |
| author_browse | Cholich, Luciana Andrea Garcia, Enrique Nicolas Gimeno, Eduardo Juan Martinez, Agustin Micheloud, Juan Francisco Ortega, Hugo Hector Pistán, Maria Elena Robles, Carlos Alejandro |
| author_facet | Cholich, Luciana Andrea Martinez, Agustin Micheloud, Juan Francisco Pistán, Maria Elena Garcia, Enrique Nicolas Robles, Carlos Alejandro Ortega, Hugo Hector Gimeno, Eduardo Juan |
| author_sort | Cholich, Luciana Andrea |
| collection | INTA Digital |
| description | It is well known that several of the swainsonine-containing plant species found widespread around the world have a negative economic impact in each country. In Argentina, most of the information on the poisonous plant species that produce α-mannosidosis is published in Spanish and thus not available to most English speaking researchers interested in toxic plants. Therefore, the aim of this review is to summarize the information about swainsonine-containing plants in Argentina, which are extensively distributed throughout different ecoregions of the country. To date, five species from three genera have been shown to induce α-mannosidosis in livestock in Argentina: Ipomoea carnea subsp. fi stulosa, Ipomoea hieronymi subsp. calchaquina (Convolvulaceae), Astragalus garbancillo, Astragalus pehuenches (Fabaceae), and Sida rodrigoi (Malvaceae). These species contain the indolizidine alkaloid swainsonine, which inhibits the lysosomal enzyme α-mannosidase and consequently affects glycoprotein metabolism, resulting in partially metabolized sugars. The prolonged consumption of these poisonous plants produces progressive weight loss and clinical signs related to a nervous disorder, characterized by tremors of head and neck, abnormalities of gait, difficulty in standing, ataxia and wide-based stance. Histological lesions are mainly characterized by vacuolation of different cells, especially neurons of the central
nervous system. The main animal model used to study α-mannosidosis is the guinea pig because, when experimentally poisoned, it exhibits many of the characteristics of naturally intoxicated livestock. |
| format | Artículo |
| id | INTA10720 |
| institution | Instituto Nacional de Tecnología Agropecuaria (INTA -Argentina) |
| language | Inglés |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Academia Brasileira de Ciencias |
| publisherStr | Academia Brasileira de Ciencias |
| record_format | dspace |
| spelling | INTA107202022-12-22T10:38:17Z Alpha-mannosidosis caused by toxic plants in ruminants of Argentina Cholich, Luciana Andrea Martinez, Agustin Micheloud, Juan Francisco Pistán, Maria Elena Garcia, Enrique Nicolas Robles, Carlos Alejandro Ortega, Hugo Hector Gimeno, Eduardo Juan Plantas Tóxicas Inmunodeficiencia Astragalus Envenenamiento Poisonous Plants Immunodeficiency Poisoning Swainsonine Alfa-manosidosis It is well known that several of the swainsonine-containing plant species found widespread around the world have a negative economic impact in each country. In Argentina, most of the information on the poisonous plant species that produce α-mannosidosis is published in Spanish and thus not available to most English speaking researchers interested in toxic plants. Therefore, the aim of this review is to summarize the information about swainsonine-containing plants in Argentina, which are extensively distributed throughout different ecoregions of the country. To date, five species from three genera have been shown to induce α-mannosidosis in livestock in Argentina: Ipomoea carnea subsp. fi stulosa, Ipomoea hieronymi subsp. calchaquina (Convolvulaceae), Astragalus garbancillo, Astragalus pehuenches (Fabaceae), and Sida rodrigoi (Malvaceae). These species contain the indolizidine alkaloid swainsonine, which inhibits the lysosomal enzyme α-mannosidase and consequently affects glycoprotein metabolism, resulting in partially metabolized sugars. The prolonged consumption of these poisonous plants produces progressive weight loss and clinical signs related to a nervous disorder, characterized by tremors of head and neck, abnormalities of gait, difficulty in standing, ataxia and wide-based stance. Histological lesions are mainly characterized by vacuolation of different cells, especially neurons of the central nervous system. The main animal model used to study α-mannosidosis is the guinea pig because, when experimentally poisoned, it exhibits many of the characteristics of naturally intoxicated livestock. Estación Experimental Agropecuaria Bariloche Fil: Cholich, Luciana Andrea. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina Fil: Cholich, Luciana Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Martinez, Agustin. Instituto Nacional de Tecnologia Agropecuaria (INTA). Estacion Experimental Agropecuaria Bariloche. Grupo de Sanidad Animal; Argentina Fil: Micheloud, Juan Francisco. Universidad Católica de Salta. Facultad de Ciencias Veterinarias y Agronomía; Argentina Fil: Micheloud, Juan Francisco. Instituto Nacional de Tecnologia Agropecuaria (INTA). Instituto de Investigación Animal del Chaco Semiárido. Área de Sanidad Animal; Argentina Fil: Pistán, Maria Elena. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina Fil: Garcia, Enrique Nicolas. Universidad Nacional del Nordeste. Facultad de Ciencias Veterinarias; Argentina Fil: Robles, Carlos Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Grupo de Sanidad Animal; Argentina Fil: Ortega, Hugo Hector. Universidad Nacional del Litoral. Instituto de Ciencias Veterinarias del Litoral; Argentina Fil: Ortega, Hugo Hector. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Gimeno, Eduardo Juan. Universidad Nacional de la Plata. Facultad de Ciencias Veterinarias; Argentina Fil: Gimeno, Eduardo Juan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina 2021-11-09T12:06:04Z 2021-11-09T12:06:04Z 2021 info:ar-repo/semantics/artículo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/20.500.12123/10720 https://www.scielo.br/j/aabc/a/phRKSPsNW73QJN8C7jWTjnL/?lang=en 0001-3765 1678-2690 https://doi.org/10.1590/0001-3765202120191496 eng info:eu-repograntAgreement/INTA/PATNOR-1281102/AR./Aportes a la recuperación y desarrollo territorial del semiárido sur de la provincia de Rio Negro. info:eu-repograntAgreement/INTA/PNSA-1115054/AR./Enfermedades parasitarias, infecciosas y tóxico metabólicas que afectan la productividad de los bóvidos para producción de carne y leche. info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf Academia Brasileira de Ciencias Anais da Academia Brasileira de Ciencias 93 (sup. 3) : e20191496 (2021) |
| spellingShingle | Plantas Tóxicas Inmunodeficiencia Astragalus Envenenamiento Poisonous Plants Immunodeficiency Poisoning Swainsonine Alfa-manosidosis Cholich, Luciana Andrea Martinez, Agustin Micheloud, Juan Francisco Pistán, Maria Elena Garcia, Enrique Nicolas Robles, Carlos Alejandro Ortega, Hugo Hector Gimeno, Eduardo Juan Alpha-mannosidosis caused by toxic plants in ruminants of Argentina |
| title | Alpha-mannosidosis caused by toxic plants in ruminants of Argentina |
| title_full | Alpha-mannosidosis caused by toxic plants in ruminants of Argentina |
| title_fullStr | Alpha-mannosidosis caused by toxic plants in ruminants of Argentina |
| title_full_unstemmed | Alpha-mannosidosis caused by toxic plants in ruminants of Argentina |
| title_short | Alpha-mannosidosis caused by toxic plants in ruminants of Argentina |
| title_sort | alpha mannosidosis caused by toxic plants in ruminants of argentina |
| topic | Plantas Tóxicas Inmunodeficiencia Astragalus Envenenamiento Poisonous Plants Immunodeficiency Poisoning Swainsonine Alfa-manosidosis |
| url | http://hdl.handle.net/20.500.12123/10720 https://www.scielo.br/j/aabc/a/phRKSPsNW73QJN8C7jWTjnL/?lang=en https://doi.org/10.1590/0001-3765202120191496 |
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