Genomic characterization of Escherichia coli isolates from alpaca crias (Vicugna pacos) in the peruvian highlands: insights into functional diversity and pathogenicity
Diarrhea in alpaca crias significantly impacts livestock health in high-altitude regions, with Escherichia coli as a common pathogen. This study analyzed 10 E. coli isolates from diarrheic and healthy alpacas using whole-genome sequencing to assess genetic diversity, virulence factors, and antibioti...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | Inglés |
| Publicado: |
MDPI
2025
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12955/2823 https://doi.org/10.3390/microorganisms13071533 |
| _version_ | 1855490418160959488 |
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| author | Zapata, Celso Rodriguez Perez, Lila Maciel Romero Avila, Yolanda Madedein Coila, Pedro Hañari Quispe, Renán Dilton Oros, Oscar Zanabria, Víctor Quilcate Pairazaman, Carlos Enrique Rojas Cruz, Diórman Cruz Luis, Juancarlos Alejandro Ortiz Morera, Narda Cecilia Estrada Cañari, Richard |
| author_browse | Coila, Pedro Cruz Luis, Juancarlos Alejandro Estrada Cañari, Richard Hañari Quispe, Renán Dilton Oros, Oscar Ortiz Morera, Narda Cecilia Quilcate Pairazaman, Carlos Enrique Rodriguez Perez, Lila Maciel Rojas Cruz, Diórman Romero Avila, Yolanda Madedein Zanabria, Víctor Zapata, Celso |
| author_facet | Zapata, Celso Rodriguez Perez, Lila Maciel Romero Avila, Yolanda Madedein Coila, Pedro Hañari Quispe, Renán Dilton Oros, Oscar Zanabria, Víctor Quilcate Pairazaman, Carlos Enrique Rojas Cruz, Diórman Cruz Luis, Juancarlos Alejandro Ortiz Morera, Narda Cecilia Estrada Cañari, Richard |
| author_sort | Zapata, Celso |
| collection | Repositorio INIA |
| description | Diarrhea in alpaca crias significantly impacts livestock health in high-altitude regions, with Escherichia coli as a common pathogen. This study analyzed 10 E. coli isolates from diarrheic and healthy alpacas using whole-genome sequencing to assess genetic diversity, virulence factors, and antibiotic resistance. Predominant sequence types (ST73, ST29), serotypes (O22:H1, O109:H11), and phylogroups (B2, B1, A) were identified. Virulence profiling revealed ExPEC-like and EPEC pathotypes, while resistance genes for β-lactams (blaEC-15), fosfomycin (glpT_E448K), and colistin (pmrB) were prevalent. These findings highlight the need for genomic surveillance and antimicrobial stewardship to manage E. coli infections in alpacas and reduce public health risks. |
| format | Artículo |
| id | INIA2823 |
| institution | Institucional Nacional de Innovación Agraria |
| language | Inglés |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | MDPI |
| publisherStr | MDPI |
| record_format | dspace |
| spelling | INIA28232025-08-19T04:46:32Z Genomic characterization of Escherichia coli isolates from alpaca crias (Vicugna pacos) in the peruvian highlands: insights into functional diversity and pathogenicity Zapata, Celso Rodriguez Perez, Lila Maciel Romero Avila, Yolanda Madedein Coila, Pedro Hañari Quispe, Renán Dilton Oros, Oscar Zanabria, Víctor Quilcate Pairazaman, Carlos Enrique Rojas Cruz, Diórman Cruz Luis, Juancarlos Alejandro Ortiz Morera, Narda Cecilia Estrada Cañari, Richard E. coli genetic diversity antibiotic resistance in alpacas virulence factors in alpaca pathogens Diversidad genética de E. coli resistencia a antibióticos en alpacas factores de virulencia en patógenos de alpacas https://purl.org/pe-repo/ocde/ford#4.02.02 genómica, genomics, pathogenicity; patogenicidad Diarrhea in alpaca crias significantly impacts livestock health in high-altitude regions, with Escherichia coli as a common pathogen. This study analyzed 10 E. coli isolates from diarrheic and healthy alpacas using whole-genome sequencing to assess genetic diversity, virulence factors, and antibiotic resistance. Predominant sequence types (ST73, ST29), serotypes (O22:H1, O109:H11), and phylogroups (B2, B1, A) were identified. Virulence profiling revealed ExPEC-like and EPEC pathotypes, while resistance genes for β-lactams (blaEC-15), fosfomycin (glpT_E448K), and colistin (pmrB) were prevalent. These findings highlight the need for genomic surveillance and antimicrobial stewardship to manage E. coli infections in alpacas and reduce public health risks. 2025-08-19T04:46:32Z 2025-08-19T04:46:32Z 2025-06-30 info:eu-repo/semantics/article Zapata, C., Rodriguez, L., Romero, Y., Coila, P., Hañari-Quispe, R. D., Oros, O., Zanabria, V., Quilcate, C., Rojas, D., Cruz, J., et al. (2025). Genomic characterization of Escherichia coli isolates from alpaca crias (Vicugna pacos) in the Peruvian Highlands: Insights into functional diversity and pathogenicity. Microorganisms, 13(7), 1533. https://doi.org/10.3390/microorganisms13071533 2076-2607 http://hdl.handle.net/20.500.12955/2823 https://doi.org/10.3390/microorganisms13071533 eng urn:issn:2076-2607 Microorganisms info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/4.0/ application/pdf application/pdf MDPI CH Instituto Nacional de Innovación Agraria Repositorio Institucional - INIA |
| spellingShingle | E. coli genetic diversity antibiotic resistance in alpacas virulence factors in alpaca pathogens Diversidad genética de E. coli resistencia a antibióticos en alpacas factores de virulencia en patógenos de alpacas https://purl.org/pe-repo/ocde/ford#4.02.02 genómica, genomics, pathogenicity; patogenicidad Zapata, Celso Rodriguez Perez, Lila Maciel Romero Avila, Yolanda Madedein Coila, Pedro Hañari Quispe, Renán Dilton Oros, Oscar Zanabria, Víctor Quilcate Pairazaman, Carlos Enrique Rojas Cruz, Diórman Cruz Luis, Juancarlos Alejandro Ortiz Morera, Narda Cecilia Estrada Cañari, Richard Genomic characterization of Escherichia coli isolates from alpaca crias (Vicugna pacos) in the peruvian highlands: insights into functional diversity and pathogenicity |
| title | Genomic characterization of Escherichia coli isolates from alpaca crias (Vicugna pacos) in the peruvian highlands: insights into functional diversity and pathogenicity |
| title_full | Genomic characterization of Escherichia coli isolates from alpaca crias (Vicugna pacos) in the peruvian highlands: insights into functional diversity and pathogenicity |
| title_fullStr | Genomic characterization of Escherichia coli isolates from alpaca crias (Vicugna pacos) in the peruvian highlands: insights into functional diversity and pathogenicity |
| title_full_unstemmed | Genomic characterization of Escherichia coli isolates from alpaca crias (Vicugna pacos) in the peruvian highlands: insights into functional diversity and pathogenicity |
| title_short | Genomic characterization of Escherichia coli isolates from alpaca crias (Vicugna pacos) in the peruvian highlands: insights into functional diversity and pathogenicity |
| title_sort | genomic characterization of escherichia coli isolates from alpaca crias vicugna pacos in the peruvian highlands insights into functional diversity and pathogenicity |
| topic | E. coli genetic diversity antibiotic resistance in alpacas virulence factors in alpaca pathogens Diversidad genética de E. coli resistencia a antibióticos en alpacas factores de virulencia en patógenos de alpacas https://purl.org/pe-repo/ocde/ford#4.02.02 genómica, genomics, pathogenicity; patogenicidad |
| url | http://hdl.handle.net/20.500.12955/2823 https://doi.org/10.3390/microorganisms13071533 |
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