Two novel cases of autosomal translocations in the horse: Warmblood family segregating t(4;30) and a cloned arabian with a de novo t(12;25)
We report 2 novel autosomal translocations in the horse. In Case 1, a breeding stallion with a balanced t(4p;30) had produced normal foals and those with congenital abnormalities. Of his 9 phenotypically normal offspring, 4 had normal karyotypes, 4 had balanced t(4p;30), and 1 carried an unbalanced...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | info:eu-repo/semantics/article |
| Lenguaje: | Inglés |
| Publicado: |
S. Karger AG
2023
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/20.500.12955/2196 https://doi.org/10.1159/000512206 |
| _version_ | 1855028860450504704 |
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| author | Ghosh, Sharmila Carden, Candice F. Juras, Rytis Mendoza Cerna, Mayra Nohelia Jevit, Matthew J. Castaneda, Caitlin Phelps, Olivia Dube, Jessie Kelley, Dale E. Varner, Dickson D. Love, Charley C. Raudsepp, Terje |
| author_browse | Carden, Candice F. Castaneda, Caitlin Dube, Jessie Ghosh, Sharmila Jevit, Matthew J. Juras, Rytis Kelley, Dale E. Love, Charley C. Mendoza Cerna, Mayra Nohelia Phelps, Olivia Raudsepp, Terje Varner, Dickson D. |
| author_facet | Ghosh, Sharmila Carden, Candice F. Juras, Rytis Mendoza Cerna, Mayra Nohelia Jevit, Matthew J. Castaneda, Caitlin Phelps, Olivia Dube, Jessie Kelley, Dale E. Varner, Dickson D. Love, Charley C. Raudsepp, Terje |
| author_sort | Ghosh, Sharmila |
| collection | Repositorio INIA |
| description | We report 2 novel autosomal translocations in the horse. In Case 1, a breeding stallion with a balanced t(4p;30) had produced normal foals and those with congenital abnormalities. Of his 9 phenotypically normal offspring, 4 had normal karyotypes, 4 had balanced t(4p;30), and 1 carried an unbalanced translocation with tertiary trisomy of 4p. We argue that unbalanced forms of t(4p;30) are more tolerated and result in viable congenital abnormalities, without causing embryonic death like all other known equine autosomal translocations. In Case 2, two stallions produced by somatic cell nuclear transfer from the same donor were karyotyped because of fertility issues. A balanced translocation t(12q;25) was found in one, but not in the other clone. The findings underscore the importance of routine cytogenetic screening of breeding animals and animals produced by assisted reproductive technologies. These cases will contribute to molecular studies of translocation breakpoints and their genetic consequences in the horse. |
| format | info:eu-repo/semantics/article |
| id | INIA2196 |
| institution | Institucional Nacional de Innovación Agraria |
| language | Inglés |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | S. Karger AG |
| publisherStr | S. Karger AG |
| record_format | dspace |
| spelling | INIA21962023-06-05T17:43:10Z Two novel cases of autosomal translocations in the horse: Warmblood family segregating t(4;30) and a cloned arabian with a de novo t(12;25) Ghosh, Sharmila Carden, Candice F. Juras, Rytis Mendoza Cerna, Mayra Nohelia Jevit, Matthew J. Castaneda, Caitlin Phelps, Olivia Dube, Jessie Kelley, Dale E. Varner, Dickson D. Love, Charley C. Raudsepp, Terje Balanced-unbalancedautosomal chromosome rearrangements Assisted reproductive technologies Subfertility Congenital abnormalities Horses https://purl.org/pe-repo/ocde/ford#4.02.01 Congenital abnormalities Anomalías congénitas Horses Caballos We report 2 novel autosomal translocations in the horse. In Case 1, a breeding stallion with a balanced t(4p;30) had produced normal foals and those with congenital abnormalities. Of his 9 phenotypically normal offspring, 4 had normal karyotypes, 4 had balanced t(4p;30), and 1 carried an unbalanced translocation with tertiary trisomy of 4p. We argue that unbalanced forms of t(4p;30) are more tolerated and result in viable congenital abnormalities, without causing embryonic death like all other known equine autosomal translocations. In Case 2, two stallions produced by somatic cell nuclear transfer from the same donor were karyotyped because of fertility issues. A balanced translocation t(12q;25) was found in one, but not in the other clone. The findings underscore the importance of routine cytogenetic screening of breeding animals and animals produced by assisted reproductive technologies. These cases will contribute to molecular studies of translocation breakpoints and their genetic consequences in the horse. 2023-06-05T17:43:06Z 2023-06-05T17:43:06Z 2020-12-16 info:eu-repo/semantics/article Certificado de obtentor-variedades vegetales Ghosh, S., Carden, C. F., Juras, R., Mendoza, M. N., Jevit, M. J., Castaneda, C., … Raudsepp, T. (2020). Two novel cases of autosomal translocations in the horse: Warmblood family segregating t(4;30) and a cloned arabian with a de novo t(12;25). Cytogenetic and Genome Research, 160(11-12), 688–697. doi:10.1159/000512206 1424-859X https://hdl.handle.net/20.500.12955/2196 https://doi.org/10.1159/000512206 eng urn:issn:1424-859X Cytogenetic and Genome Research info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc/4.0/ application/pdf S. Karger AG CH Instituto Nacional de Innovación Agraria Repositorio Institucional - INIA |
| spellingShingle | Balanced-unbalancedautosomal chromosome rearrangements Assisted reproductive technologies Subfertility Congenital abnormalities Horses https://purl.org/pe-repo/ocde/ford#4.02.01 Congenital abnormalities Anomalías congénitas Horses Caballos Ghosh, Sharmila Carden, Candice F. Juras, Rytis Mendoza Cerna, Mayra Nohelia Jevit, Matthew J. Castaneda, Caitlin Phelps, Olivia Dube, Jessie Kelley, Dale E. Varner, Dickson D. Love, Charley C. Raudsepp, Terje Two novel cases of autosomal translocations in the horse: Warmblood family segregating t(4;30) and a cloned arabian with a de novo t(12;25) |
| title | Two novel cases of autosomal translocations in the horse: Warmblood family segregating t(4;30) and a cloned arabian with a de novo t(12;25) |
| title_full | Two novel cases of autosomal translocations in the horse: Warmblood family segregating t(4;30) and a cloned arabian with a de novo t(12;25) |
| title_fullStr | Two novel cases of autosomal translocations in the horse: Warmblood family segregating t(4;30) and a cloned arabian with a de novo t(12;25) |
| title_full_unstemmed | Two novel cases of autosomal translocations in the horse: Warmblood family segregating t(4;30) and a cloned arabian with a de novo t(12;25) |
| title_short | Two novel cases of autosomal translocations in the horse: Warmblood family segregating t(4;30) and a cloned arabian with a de novo t(12;25) |
| title_sort | two novel cases of autosomal translocations in the horse warmblood family segregating t 4 30 and a cloned arabian with a de novo t 12 25 |
| topic | Balanced-unbalancedautosomal chromosome rearrangements Assisted reproductive technologies Subfertility Congenital abnormalities Horses https://purl.org/pe-repo/ocde/ford#4.02.01 Congenital abnormalities Anomalías congénitas Horses Caballos |
| url | https://hdl.handle.net/20.500.12955/2196 https://doi.org/10.1159/000512206 |
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