Nanoformulations with Leishmania braziliensis antigens triggered controlled parasite burden in vaccinated golden hamster (Mesocricetus auratus) against visceral Leishmaniasis

Leishmaniasis is a widespread vector-borne disease in Brazil, with Leishmania (Leishmania) infantum as the primary etiological agent of visceral leishmaniasis (VL). Dogs are considered the main reservoir of this parasite, whose treatment in Brazil is restricted to the use of veterinary medicines, wh...

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Main Authors: Ottino, Jennifer, Leite, Jaqueline Costa, Melo Júnior, Otoni Alves, Cabrera González, Marco Antonio, de Carvalho, Tatiane Furtado, Garcia, Giani Martins, Batista, Maurício Azevedo, Silveira, Patrícia, Cardoso, Mariana Santos, Bueno, Lilian Lacerda, Fujiwara, Ricardo Toshio, Santos, Renato Lima, Paes, Paulo Ricardo de Oliveira, Silveira Lemos, Denise, Martins Filho, Olindo Assis, Galdino, Alexsandro Sobreira, Chávez Fumagalli, Miguel Angel, Dutra, Walderez Ornelas, Mosqueira, Vanessa Carla Furtado, Giunchetti, Rodolfo Cordeiro
Format: Artículo
Language:Español
Published: MDPI 2023
Subjects:
Online Access:https://hdl.handle.net/20.500.12955/2110
https://doi.org/10.3390/vaccines10111848
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author Ottino, Jennifer
Leite, Jaqueline Costa
Melo Júnior, Otoni Alves
Cabrera González, Marco Antonio
de Carvalho, Tatiane Furtado
Garcia, Giani Martins
Batista, Maurício Azevedo
Silveira, Patrícia
Cardoso, Mariana Santos
Bueno, Lilian Lacerda
Fujiwara, Ricardo Toshio
Santos, Renato Lima
Paes, Paulo Ricardo de Oliveira
Silveira Lemos, Denise
Martins Filho, Olindo Assis
Galdino, Alexsandro Sobreira
Chávez Fumagalli, Miguel Angel
Dutra, Walderez Ornelas
Mosqueira, Vanessa Carla Furtado
Giunchetti, Rodolfo Cordeiro
author_browse Batista, Maurício Azevedo
Bueno, Lilian Lacerda
Cabrera González, Marco Antonio
Cardoso, Mariana Santos
Chávez Fumagalli, Miguel Angel
Dutra, Walderez Ornelas
Fujiwara, Ricardo Toshio
Galdino, Alexsandro Sobreira
Garcia, Giani Martins
Giunchetti, Rodolfo Cordeiro
Leite, Jaqueline Costa
Martins Filho, Olindo Assis
Melo Júnior, Otoni Alves
Mosqueira, Vanessa Carla Furtado
Ottino, Jennifer
Paes, Paulo Ricardo de Oliveira
Santos, Renato Lima
Silveira Lemos, Denise
Silveira, Patrícia
de Carvalho, Tatiane Furtado
author_facet Ottino, Jennifer
Leite, Jaqueline Costa
Melo Júnior, Otoni Alves
Cabrera González, Marco Antonio
de Carvalho, Tatiane Furtado
Garcia, Giani Martins
Batista, Maurício Azevedo
Silveira, Patrícia
Cardoso, Mariana Santos
Bueno, Lilian Lacerda
Fujiwara, Ricardo Toshio
Santos, Renato Lima
Paes, Paulo Ricardo de Oliveira
Silveira Lemos, Denise
Martins Filho, Olindo Assis
Galdino, Alexsandro Sobreira
Chávez Fumagalli, Miguel Angel
Dutra, Walderez Ornelas
Mosqueira, Vanessa Carla Furtado
Giunchetti, Rodolfo Cordeiro
author_sort Ottino, Jennifer
collection Repositorio INIA
description Leishmaniasis is a widespread vector-borne disease in Brazil, with Leishmania (Leishmania) infantum as the primary etiological agent of visceral leishmaniasis (VL). Dogs are considered the main reservoir of this parasite, whose treatment in Brazil is restricted to the use of veterinary medicines, which do not promote a parasitological cure. Therefore, efficient vaccine development is the best approach to Canine Visceral Leishmaniasis (CVL) control. With this in mind, this study used hamsters (Mesocricetus auratus) as an experimental model in an anti-Leishmania preclinical vaccine trial to evaluate the safety, antigenicity, humoral response, and effects on tissue parasite load. Two novel formulations of nanoparticles made from poly(D, L-lactic) acid (PLA) polymer loading Leishmania braziliensis crude antigen (LB) exhibiting two different particle sizes were utilized: LBPSmG (570 nm) and LBPSmP (388 nm). The results showed that the nanoparticles were safe and harmless to hamsters and were antigenic with the induction in LBSap, LBPSmG, and LBPSmG groups of total anti-Leishmania IgG antibodies 30 days after challenge, which persists 200 days in LBSap and LBPSmP. At the same time, a less pronounced hepatosplenomegaly in LBSap, LBPSmG, and LBPSmP was found when compared to control groups, as well as a less pronounced inflammatory infiltrate and granuloma formation in the spleen. Furthermore, significant reductions of 84%, 81%, and 90% were observed in spleen parasite burden accessed by qPCR in the LBSap, LBPSmG, and LBPSmP groups, respectively. In this way, LBSap, LBPSmG, and LBPSmP formulations showed better results in vaccinated and L. infantum-challenged animals in further reducing parasitic load in the spleen and attenuating lesions in liver and splenic tissues. This results in safe, harmless nanoformulation vaccines with significant immunogenic and infection control potential. In addition, animals vaccinated with LBPSmP had an overall reduction in parasite burden in the spleen, indicating that a smaller nanoparticle could be more efficient in targeting antigen-presenting cells.
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spelling INIA21102025-05-25T23:19:35Z Nanoformulations with Leishmania braziliensis antigens triggered controlled parasite burden in vaccinated golden hamster (Mesocricetus auratus) against visceral Leishmaniasis Ottino, Jennifer Leite, Jaqueline Costa Melo Júnior, Otoni Alves Cabrera González, Marco Antonio de Carvalho, Tatiane Furtado Garcia, Giani Martins Batista, Maurício Azevedo Silveira, Patrícia Cardoso, Mariana Santos Bueno, Lilian Lacerda Fujiwara, Ricardo Toshio Santos, Renato Lima Paes, Paulo Ricardo de Oliveira Silveira Lemos, Denise Martins Filho, Olindo Assis Galdino, Alexsandro Sobreira Chávez Fumagalli, Miguel Angel Dutra, Walderez Ornelas Mosqueira, Vanessa Carla Furtado Giunchetti, Rodolfo Cordeiro Visceral leishmaniasis Polymeric nanoparticle Vaccine Hamster Pre-clinical trial https://purl.org/pe-repo/ocde/ford#1.06.01 Leishmaniasis Hamsters Mesocricetus auratus Leishmaniasis is a widespread vector-borne disease in Brazil, with Leishmania (Leishmania) infantum as the primary etiological agent of visceral leishmaniasis (VL). Dogs are considered the main reservoir of this parasite, whose treatment in Brazil is restricted to the use of veterinary medicines, which do not promote a parasitological cure. Therefore, efficient vaccine development is the best approach to Canine Visceral Leishmaniasis (CVL) control. With this in mind, this study used hamsters (Mesocricetus auratus) as an experimental model in an anti-Leishmania preclinical vaccine trial to evaluate the safety, antigenicity, humoral response, and effects on tissue parasite load. Two novel formulations of nanoparticles made from poly(D, L-lactic) acid (PLA) polymer loading Leishmania braziliensis crude antigen (LB) exhibiting two different particle sizes were utilized: LBPSmG (570 nm) and LBPSmP (388 nm). The results showed that the nanoparticles were safe and harmless to hamsters and were antigenic with the induction in LBSap, LBPSmG, and LBPSmG groups of total anti-Leishmania IgG antibodies 30 days after challenge, which persists 200 days in LBSap and LBPSmP. At the same time, a less pronounced hepatosplenomegaly in LBSap, LBPSmG, and LBPSmP was found when compared to control groups, as well as a less pronounced inflammatory infiltrate and granuloma formation in the spleen. Furthermore, significant reductions of 84%, 81%, and 90% were observed in spleen parasite burden accessed by qPCR in the LBSap, LBPSmG, and LBPSmP groups, respectively. In this way, LBSap, LBPSmG, and LBPSmP formulations showed better results in vaccinated and L. infantum-challenged animals in further reducing parasitic load in the spleen and attenuating lesions in liver and splenic tissues. This results in safe, harmless nanoformulation vaccines with significant immunogenic and infection control potential. In addition, animals vaccinated with LBPSmP had an overall reduction in parasite burden in the spleen, indicating that a smaller nanoparticle could be more efficient in targeting antigen-presenting cells. 2023-03-10T19:44:59Z 2023-03-10T19:44:59Z 2022-10-31 info:eu-repo/semantics/article Ottino, J., Leite, J. C., Melo-Júnior, O. A., González, M. A. C., de Carvalho, T. F., Garcia, G. M., Batista, M. A., Silveira, P., Cardoso, M. S., Bueno, L. L., Fujiwara, R. T., Santos, R. L., Paes, P. R. de O., Silveira-Lemos, D., Martins-Filho, O. A., Galdino, A. S., Chávez-Fumagalli, M. A., Dutra, W. O., Mosqueira, V. C. F., & Giunchetti, R. C. (2022). Nanoformulations with Leishmania braziliensis antigens triggered controlled parasite burden in vaccinated golden hamster (Mesocricetus auratus) against visceral Leishmaniasis. Vaccines, 10(11), 1848. doi: 10.3390/vaccines10111848 2076-393X https://hdl.handle.net/20.500.12955/2110 https://doi.org/10.3390/vaccines10111848 spa urn:issn:2076-393X Vaccines info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/4.0/ application/pdf application/pdf MDPI CH Instituto Nacional de Innovación Agraria Repositorio Institucional - INIA
spellingShingle Visceral leishmaniasis
Polymeric nanoparticle
Vaccine
Hamster
Pre-clinical trial
https://purl.org/pe-repo/ocde/ford#1.06.01
Leishmaniasis
Hamsters
Mesocricetus auratus
Ottino, Jennifer
Leite, Jaqueline Costa
Melo Júnior, Otoni Alves
Cabrera González, Marco Antonio
de Carvalho, Tatiane Furtado
Garcia, Giani Martins
Batista, Maurício Azevedo
Silveira, Patrícia
Cardoso, Mariana Santos
Bueno, Lilian Lacerda
Fujiwara, Ricardo Toshio
Santos, Renato Lima
Paes, Paulo Ricardo de Oliveira
Silveira Lemos, Denise
Martins Filho, Olindo Assis
Galdino, Alexsandro Sobreira
Chávez Fumagalli, Miguel Angel
Dutra, Walderez Ornelas
Mosqueira, Vanessa Carla Furtado
Giunchetti, Rodolfo Cordeiro
Nanoformulations with Leishmania braziliensis antigens triggered controlled parasite burden in vaccinated golden hamster (Mesocricetus auratus) against visceral Leishmaniasis
title Nanoformulations with Leishmania braziliensis antigens triggered controlled parasite burden in vaccinated golden hamster (Mesocricetus auratus) against visceral Leishmaniasis
title_full Nanoformulations with Leishmania braziliensis antigens triggered controlled parasite burden in vaccinated golden hamster (Mesocricetus auratus) against visceral Leishmaniasis
title_fullStr Nanoformulations with Leishmania braziliensis antigens triggered controlled parasite burden in vaccinated golden hamster (Mesocricetus auratus) against visceral Leishmaniasis
title_full_unstemmed Nanoformulations with Leishmania braziliensis antigens triggered controlled parasite burden in vaccinated golden hamster (Mesocricetus auratus) against visceral Leishmaniasis
title_short Nanoformulations with Leishmania braziliensis antigens triggered controlled parasite burden in vaccinated golden hamster (Mesocricetus auratus) against visceral Leishmaniasis
title_sort nanoformulations with leishmania braziliensis antigens triggered controlled parasite burden in vaccinated golden hamster mesocricetus auratus against visceral leishmaniasis
topic Visceral leishmaniasis
Polymeric nanoparticle
Vaccine
Hamster
Pre-clinical trial
https://purl.org/pe-repo/ocde/ford#1.06.01
Leishmaniasis
Hamsters
Mesocricetus auratus
url https://hdl.handle.net/20.500.12955/2110
https://doi.org/10.3390/vaccines10111848
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