The major histocompatibility complex homozygous inbred Babraham pig as a resource for veterinary and translational medicine
The Babraham pig is a highly inbred breed first developed in the United Kingdom approximately 50 years ago. Previous reports indicate a very high degree of homozygosity across the genome, including the major histocompatibility complex (MHC) region, but confirmation of homozygosity at the specific MH...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Wiley
2018
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/99010 |
| _version_ | 1855533375914246144 |
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| author | Schwartz, J.C. Hemmink, J.D. Graham, S.P. Tchilian, E. Charleston, B. Hammer, S.E. Ho, C.S. Hammond, John A. |
| author_browse | Charleston, B. Graham, S.P. Hammer, S.E. Hammond, John A. Hemmink, J.D. Ho, C.S. Schwartz, J.C. Tchilian, E. |
| author_facet | Schwartz, J.C. Hemmink, J.D. Graham, S.P. Tchilian, E. Charleston, B. Hammer, S.E. Ho, C.S. Hammond, John A. |
| author_sort | Schwartz, J.C. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | The Babraham pig is a highly inbred breed first developed in the United Kingdom approximately 50 years ago. Previous reports indicate a very high degree of homozygosity across the genome, including the major histocompatibility complex (MHC) region, but confirmation of homozygosity at the specific MHC loci was lacking. Using both direct sequencing and PCR‐based sequence‐specific typing, we confirm that Babraham pigs are essentially homozygous at their MHC loci and formalise their MHC haplotype as Hp‐55.6. This enhances the utility of the Babraham pig as a useful biomedical model for studies in which controlling for genetic variation is important. |
| format | Journal Article |
| id | CGSpace99010 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| publisher | Wiley |
| publisherStr | Wiley |
| record_format | dspace |
| spelling | CGSpace990102024-05-01T08:18:39Z The major histocompatibility complex homozygous inbred Babraham pig as a resource for veterinary and translational medicine Schwartz, J.C. Hemmink, J.D. Graham, S.P. Tchilian, E. Charleston, B. Hammer, S.E. Ho, C.S. Hammond, John A. animal breeding genetics swine The Babraham pig is a highly inbred breed first developed in the United Kingdom approximately 50 years ago. Previous reports indicate a very high degree of homozygosity across the genome, including the major histocompatibility complex (MHC) region, but confirmation of homozygosity at the specific MHC loci was lacking. Using both direct sequencing and PCR‐based sequence‐specific typing, we confirm that Babraham pigs are essentially homozygous at their MHC loci and formalise their MHC haplotype as Hp‐55.6. This enhances the utility of the Babraham pig as a useful biomedical model for studies in which controlling for genetic variation is important. 2018-07 2019-01-09T13:36:40Z 2019-01-09T13:36:40Z Journal Article https://hdl.handle.net/10568/99010 en Open Access Wiley Schwartz, J.C., Hemmink, J.D., Graham, S.P., Tchilian, E., Charleston, B., Hammer, S.E., Ho, C.S. and Hammond, J.A. 2018. The major histocompatibility complex homozygous inbred Babraham pig as a resource for veterinary and translational medicine. HLA 92:40–43. |
| spellingShingle | animal breeding genetics swine Schwartz, J.C. Hemmink, J.D. Graham, S.P. Tchilian, E. Charleston, B. Hammer, S.E. Ho, C.S. Hammond, John A. The major histocompatibility complex homozygous inbred Babraham pig as a resource for veterinary and translational medicine |
| title | The major histocompatibility complex homozygous inbred Babraham pig as a resource for veterinary and translational medicine |
| title_full | The major histocompatibility complex homozygous inbred Babraham pig as a resource for veterinary and translational medicine |
| title_fullStr | The major histocompatibility complex homozygous inbred Babraham pig as a resource for veterinary and translational medicine |
| title_full_unstemmed | The major histocompatibility complex homozygous inbred Babraham pig as a resource for veterinary and translational medicine |
| title_short | The major histocompatibility complex homozygous inbred Babraham pig as a resource for veterinary and translational medicine |
| title_sort | major histocompatibility complex homozygous inbred babraham pig as a resource for veterinary and translational medicine |
| topic | animal breeding genetics swine |
| url | https://hdl.handle.net/10568/99010 |
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