Serological evidence for the circulation of ebolaviruses in pigs from Sierra Leone
Many human ebolavirus outbreaks have been linked to contact with wildlife including nonhuman primates and bats, which are assumed to serve as host species. However, it is largely unknown to what extent other animal species, particularly livestock, are involved in the transmission cycle or act as add...
| Autores principales: | , , , , , , , , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Oxford University Press
2018
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| Acceso en línea: | https://hdl.handle.net/10568/99009 |
| _version_ | 1855528347407220736 |
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| author | Fischer, K. Jabaty, J. Suluku, R. Strecker, T. Groseth, A. Fehling, S.K. Balkema-Buschmann, A. Koroma, B. Schmidt, K.M. Atherstone, Christine Weingartl, H.M. Mettenleiter, T.C. Groschup, M.H. Hoenen, T. Diederich, S. |
| author_browse | Atherstone, Christine Balkema-Buschmann, A. Diederich, S. Fehling, S.K. Fischer, K. Groschup, M.H. Groseth, A. Hoenen, T. Jabaty, J. Koroma, B. Mettenleiter, T.C. Schmidt, K.M. Strecker, T. Suluku, R. Weingartl, H.M. |
| author_facet | Fischer, K. Jabaty, J. Suluku, R. Strecker, T. Groseth, A. Fehling, S.K. Balkema-Buschmann, A. Koroma, B. Schmidt, K.M. Atherstone, Christine Weingartl, H.M. Mettenleiter, T.C. Groschup, M.H. Hoenen, T. Diederich, S. |
| author_sort | Fischer, K. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Many human ebolavirus outbreaks have been linked to contact with wildlife including nonhuman primates and bats, which are assumed to serve as host species. However, it is largely unknown to what extent other animal species, particularly livestock, are involved in the transmission cycle or act as additional hosts for filoviruses. Pigs were identified as a susceptible host for Reston virus with subsequent transmission to humans reported in the Philippines. To date, there is no evidence of natural Ebola virus (EBOV) infection in pigs, although pigs were shown to be susceptible to EBOV infection under experimental settings. To investigate the potential role of pigs in the ecology of EBOV, we analyzed 400 porcine serum samples from Sierra Leone for the presence of ebolavirus-specific antibodies. Three samples reacted with ebolavirus nucleoproteins but had no neutralizing antibodies. Our results (1) suggest the circulation of ebolaviruses in swine in Sierra Leone that are antigenically related but not identical to EBOV and (2) could represent undiscovered ebolaviruses with unknown pathogenic and/or zoonotic potential. |
| format | Journal Article |
| id | CGSpace99009 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| publisher | Oxford University Press |
| publisherStr | Oxford University Press |
| record_format | dspace |
| spelling | CGSpace990092024-11-15T08:52:37Z Serological evidence for the circulation of ebolaviruses in pigs from Sierra Leone Fischer, K. Jabaty, J. Suluku, R. Strecker, T. Groseth, A. Fehling, S.K. Balkema-Buschmann, A. Koroma, B. Schmidt, K.M. Atherstone, Christine Weingartl, H.M. Mettenleiter, T.C. Groschup, M.H. Hoenen, T. Diederich, S. animal diseases epidemiology swine zoonoses health Many human ebolavirus outbreaks have been linked to contact with wildlife including nonhuman primates and bats, which are assumed to serve as host species. However, it is largely unknown to what extent other animal species, particularly livestock, are involved in the transmission cycle or act as additional hosts for filoviruses. Pigs were identified as a susceptible host for Reston virus with subsequent transmission to humans reported in the Philippines. To date, there is no evidence of natural Ebola virus (EBOV) infection in pigs, although pigs were shown to be susceptible to EBOV infection under experimental settings. To investigate the potential role of pigs in the ecology of EBOV, we analyzed 400 porcine serum samples from Sierra Leone for the presence of ebolavirus-specific antibodies. Three samples reacted with ebolavirus nucleoproteins but had no neutralizing antibodies. Our results (1) suggest the circulation of ebolaviruses in swine in Sierra Leone that are antigenically related but not identical to EBOV and (2) could represent undiscovered ebolaviruses with unknown pathogenic and/or zoonotic potential. 2018-11-22 2019-01-09T13:35:04Z 2019-01-09T13:35:04Z Journal Article https://hdl.handle.net/10568/99009 en Open Access Oxford University Press Fischer, K., Jabaty, J., Suluku, R., Strecker, T., Groseth, A., Fehling, S.K., Balkema-Buschmann, A., Koroma, B., Schmidt, K.M., Atherstone, C., Weingartl, H.M., Mettenleiter, T.C., Groschup, M.H., Hoenen, T. and Diederich, S. 2018. Serological evidence for the circulation of ebolaviruses in pigs from Sierra Leone. Journal of Infectious Diseases 218(suppl_5): S305–S311. |
| spellingShingle | animal diseases epidemiology swine zoonoses health Fischer, K. Jabaty, J. Suluku, R. Strecker, T. Groseth, A. Fehling, S.K. Balkema-Buschmann, A. Koroma, B. Schmidt, K.M. Atherstone, Christine Weingartl, H.M. Mettenleiter, T.C. Groschup, M.H. Hoenen, T. Diederich, S. Serological evidence for the circulation of ebolaviruses in pigs from Sierra Leone |
| title | Serological evidence for the circulation of ebolaviruses in pigs from Sierra Leone |
| title_full | Serological evidence for the circulation of ebolaviruses in pigs from Sierra Leone |
| title_fullStr | Serological evidence for the circulation of ebolaviruses in pigs from Sierra Leone |
| title_full_unstemmed | Serological evidence for the circulation of ebolaviruses in pigs from Sierra Leone |
| title_short | Serological evidence for the circulation of ebolaviruses in pigs from Sierra Leone |
| title_sort | serological evidence for the circulation of ebolaviruses in pigs from sierra leone |
| topic | animal diseases epidemiology swine zoonoses health |
| url | https://hdl.handle.net/10568/99009 |
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