In vivo role of capsular polysaccharide in Mycoplasma mycoides
Capsular polysaccharides have been confirmed to be an important virulence trait in many gram-positive and gram-negative bacteria. Similarly, they are proposed to be virulence traits in minimal Mycoplasma that cause disease in humans and animals. In the current study, goats were infected with the cap...
| Main Authors: | , , , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Oxford University Press
2019
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/98924 |
| _version_ | 1855516113971970048 |
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| author | Jores, Joerg Schieck, Elise G. Liljander, Anne M. Sacchini, Flavio Posthaus, H. Lartigue, C. Blanchard, Alain Labroussaa, F. Vashee, S. |
| author_browse | Blanchard, Alain Jores, Joerg Labroussaa, F. Lartigue, C. Liljander, Anne M. Posthaus, H. Sacchini, Flavio Schieck, Elise G. Vashee, S. |
| author_facet | Jores, Joerg Schieck, Elise G. Liljander, Anne M. Sacchini, Flavio Posthaus, H. Lartigue, C. Blanchard, Alain Labroussaa, F. Vashee, S. |
| author_sort | Jores, Joerg |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Capsular polysaccharides have been confirmed to be an important virulence trait in many gram-positive and gram-negative bacteria. Similarly, they are proposed to be virulence traits in minimal Mycoplasma that cause disease in humans and animals. In the current study, goats were infected with the caprine pathogen Mycoplasma mycoides subsp. capri or an engineered mutant lacking the capsular polysaccharide, galactofuranose. Goats infected with the mutant strain showed only transient fever. In contrast, 5 of 8 goats infected with the parental strain reached end-point criteria after infection. These findings confirm that galactofuranose is a virulence factor in M. mycoides. |
| format | Journal Article |
| id | CGSpace98924 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2019 |
| publishDateRange | 2019 |
| publishDateSort | 2019 |
| publisher | Oxford University Press |
| publisherStr | Oxford University Press |
| record_format | dspace |
| spelling | CGSpace989242025-12-08T09:54:28Z In vivo role of capsular polysaccharide in Mycoplasma mycoides Jores, Joerg Schieck, Elise G. Liljander, Anne M. Sacchini, Flavio Posthaus, H. Lartigue, C. Blanchard, Alain Labroussaa, F. Vashee, S. animal diseases health goats small ruminants vaccines zoonoses infectious diseases Capsular polysaccharides have been confirmed to be an important virulence trait in many gram-positive and gram-negative bacteria. Similarly, they are proposed to be virulence traits in minimal Mycoplasma that cause disease in humans and animals. In the current study, goats were infected with the caprine pathogen Mycoplasma mycoides subsp. capri or an engineered mutant lacking the capsular polysaccharide, galactofuranose. Goats infected with the mutant strain showed only transient fever. In contrast, 5 of 8 goats infected with the parental strain reached end-point criteria after infection. These findings confirm that galactofuranose is a virulence factor in M. mycoides. 2019-04-19 2019-01-02T12:19:18Z 2019-01-02T12:19:18Z Journal Article https://hdl.handle.net/10568/98924 en Open Access Oxford University Press Jores, J., Schieck, E., Liljander, A., Sacchini, F., Posthaus, H., Lartigue, C., Blanchard, A., Labroussaa, F. and Vashee, S. 2019. In vivo role of capsular polysaccharide in Mycoplasma mycoides. Journal of Infectious Diseases 219(10):1559–1563. |
| spellingShingle | animal diseases health goats small ruminants vaccines zoonoses infectious diseases Jores, Joerg Schieck, Elise G. Liljander, Anne M. Sacchini, Flavio Posthaus, H. Lartigue, C. Blanchard, Alain Labroussaa, F. Vashee, S. In vivo role of capsular polysaccharide in Mycoplasma mycoides |
| title | In vivo role of capsular polysaccharide in Mycoplasma mycoides |
| title_full | In vivo role of capsular polysaccharide in Mycoplasma mycoides |
| title_fullStr | In vivo role of capsular polysaccharide in Mycoplasma mycoides |
| title_full_unstemmed | In vivo role of capsular polysaccharide in Mycoplasma mycoides |
| title_short | In vivo role of capsular polysaccharide in Mycoplasma mycoides |
| title_sort | in vivo role of capsular polysaccharide in mycoplasma mycoides |
| topic | animal diseases health goats small ruminants vaccines zoonoses infectious diseases |
| url | https://hdl.handle.net/10568/98924 |
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