Polymorphisms in MC1R and ASIP Genes are associated with Coat Color Variation in the Arabian Camel
Pigmentation in mammals is primarily determined by the distribution of eumelanin and pheomelanin, the ratio of which is mostly controlled by the activity of melanocortin 1 receptor (MC1R) and agouti signaling protein (ASIP) genes. Using 91 animals from 10 Arabian camel populations, that included the...
| Autores principales: | , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Oxford University Press
2018
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/97018 |
| _version_ | 1855541986427142144 |
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| author | Almathen, Faisal Elbir, Haitham Bahbahani, Hussain Mwacharo, Joram M. Hanotte, Olivier H. |
| author_browse | Almathen, Faisal Bahbahani, Hussain Elbir, Haitham Hanotte, Olivier H. Mwacharo, Joram M. |
| author_facet | Almathen, Faisal Elbir, Haitham Bahbahani, Hussain Mwacharo, Joram M. Hanotte, Olivier H. |
| author_sort | Almathen, Faisal |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Pigmentation in mammals is primarily determined by the distribution of eumelanin and pheomelanin, the ratio of which is mostly controlled by the activity of melanocortin 1 receptor (MC1R) and agouti signaling protein (ASIP) genes. Using 91 animals from 10 Arabian camel populations, that included the 4 predominant coat color phenotypes observed in the dromedary (light brown, dark brown, black, and white), we investigated the effects of the MC1R and ASIP sequence variants and identified candidate polymorphisms associated with coat color variation. In particular, we identified a single nucleotide polymorphism (SNP), found in the coding region of MC1R (901C/T), linked to the white coat color, whereas a 1-bp deletion (23delT/T) and a SNP (25G/A) in exon 2 of ASIP are associated with both black and dark-brown coat colors. Our results also indicate support that the light-brown coat color is likely the ancestral coat color for the dromedary. These sequence variations at the MC1R and ASIP genes represent the first documented evidence of candidate polymorphisms associated with Mendelian traits in the dromedary. |
| format | Journal Article |
| id | CGSpace97018 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| publisher | Oxford University Press |
| publisherStr | Oxford University Press |
| record_format | dspace |
| spelling | CGSpace970182023-12-08T19:36:04Z Polymorphisms in MC1R and ASIP Genes are associated with Coat Color Variation in the Arabian Camel Almathen, Faisal Elbir, Haitham Bahbahani, Hussain Mwacharo, Joram M. Hanotte, Olivier H. camels animal breeding livestock Pigmentation in mammals is primarily determined by the distribution of eumelanin and pheomelanin, the ratio of which is mostly controlled by the activity of melanocortin 1 receptor (MC1R) and agouti signaling protein (ASIP) genes. Using 91 animals from 10 Arabian camel populations, that included the 4 predominant coat color phenotypes observed in the dromedary (light brown, dark brown, black, and white), we investigated the effects of the MC1R and ASIP sequence variants and identified candidate polymorphisms associated with coat color variation. In particular, we identified a single nucleotide polymorphism (SNP), found in the coding region of MC1R (901C/T), linked to the white coat color, whereas a 1-bp deletion (23delT/T) and a SNP (25G/A) in exon 2 of ASIP are associated with both black and dark-brown coat colors. Our results also indicate support that the light-brown coat color is likely the ancestral coat color for the dromedary. These sequence variations at the MC1R and ASIP genes represent the first documented evidence of candidate polymorphisms associated with Mendelian traits in the dromedary. 2018-08-24 2018-08-31T05:56:38Z 2018-08-31T05:56:38Z Journal Article https://hdl.handle.net/10568/97018 en Open Access Oxford University Press Almathen, F., Elbir, H., Bahbahani, H., Mwacharo, J. and Hanotte, O. 2018. Polymorphisms in MC1R and ASIP Genes are associated with Coat Color Variation in the Arabian Camel. Journal of Heredity 109(6):700–706. |
| spellingShingle | camels animal breeding livestock Almathen, Faisal Elbir, Haitham Bahbahani, Hussain Mwacharo, Joram M. Hanotte, Olivier H. Polymorphisms in MC1R and ASIP Genes are associated with Coat Color Variation in the Arabian Camel |
| title | Polymorphisms in MC1R and ASIP Genes are associated with Coat Color Variation in the Arabian Camel |
| title_full | Polymorphisms in MC1R and ASIP Genes are associated with Coat Color Variation in the Arabian Camel |
| title_fullStr | Polymorphisms in MC1R and ASIP Genes are associated with Coat Color Variation in the Arabian Camel |
| title_full_unstemmed | Polymorphisms in MC1R and ASIP Genes are associated with Coat Color Variation in the Arabian Camel |
| title_short | Polymorphisms in MC1R and ASIP Genes are associated with Coat Color Variation in the Arabian Camel |
| title_sort | polymorphisms in mc1r and asip genes are associated with coat color variation in the arabian camel |
| topic | camels animal breeding livestock |
| url | https://hdl.handle.net/10568/97018 |
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