Containment studies of transgenic mosquitoes in disease endemic countries: The broad concept of facilities readiness
Genetic strategies for large scale pest or vector control using modified insects are not yet operational in Africa, and currently rely on import of the modified strains to begin preliminary, contained studies. Early involvement of research teams from participating countries is crucial to evaluate ca...
| Autores principales: | , , , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Mary Ann Liebert Inc
2018
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| Acceso en línea: | https://hdl.handle.net/10568/92438 |
| _version_ | 1855533928441446400 |
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| author | Quinlan, M. Megan Birungi, Josephine Coulibaly, Mamadou B. Diabaté, Abdoulaye Facchinelli, Luca Mukabana, Wolfgang R. Mutunga James M. Nolan, Tony Raymond, Peter Traoré, Sékou F. |
| author_browse | Birungi, Josephine Coulibaly, Mamadou B. Diabaté, Abdoulaye Facchinelli, Luca Mukabana, Wolfgang R. Mutunga James M. Nolan, Tony Quinlan, M. Megan Raymond, Peter Traoré, Sékou F. |
| author_facet | Quinlan, M. Megan Birungi, Josephine Coulibaly, Mamadou B. Diabaté, Abdoulaye Facchinelli, Luca Mukabana, Wolfgang R. Mutunga James M. Nolan, Tony Raymond, Peter Traoré, Sékou F. |
| author_sort | Quinlan, M. Megan |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Genetic strategies for large scale pest or vector control using modified insects are not yet operational in Africa, and currently rely on import of the modified strains to begin preliminary, contained studies. Early involvement of research teams from participating countries is crucial to evaluate candidate field interventions. Following the recommended phased approach for novel strategies, evaluation should begin with studies in containment facilities. Experiences to prepare facilities and build international teams for research on transgenic mosquitoes revealed some important organizing themes underlying the concept of “facilities readiness,” or the point at which studies in containment may proceed, in sub-Saharan African settings. First, “compliance” for research with novel or non-native living organisms was defined as the fulfillment of all legislative and regulatory requirements. This is not limited to regulations regarding use of transgenic organisms. Second, the concept of “colony utility” was related to the characteristics of laboratory colonies being produced so that results of studies may be validated across time, sites, and strains or technologies; so that the appropriate candidate strains are moved forward toward field studies. Third, the importance of achieving “defensible science” was recognized, including that study conclusions can be traced back to evidence, covering the concerns of various stakeholders over the long term. This, combined with good stewardship of resources and appropriate funding, covers a diverse set of criteria for declaring when “facilities readiness” has been attained. It is proposed that, despite the additional demands on time and resources, only with the balance of and rigorous achievement of each of these organizing themes can collaborative research into novel strategies in vector or pest control reliably progress past initial containment studies. |
| format | Journal Article |
| id | CGSpace92438 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| publisher | Mary Ann Liebert Inc |
| publisherStr | Mary Ann Liebert Inc |
| record_format | dspace |
| spelling | CGSpace924382024-01-12T10:00:54Z Containment studies of transgenic mosquitoes in disease endemic countries: The broad concept of facilities readiness Quinlan, M. Megan Birungi, Josephine Coulibaly, Mamadou B. Diabaté, Abdoulaye Facchinelli, Luca Mukabana, Wolfgang R. Mutunga James M. Nolan, Tony Raymond, Peter Traoré, Sékou F. disease control health livestock zoonoses Genetic strategies for large scale pest or vector control using modified insects are not yet operational in Africa, and currently rely on import of the modified strains to begin preliminary, contained studies. Early involvement of research teams from participating countries is crucial to evaluate candidate field interventions. Following the recommended phased approach for novel strategies, evaluation should begin with studies in containment facilities. Experiences to prepare facilities and build international teams for research on transgenic mosquitoes revealed some important organizing themes underlying the concept of “facilities readiness,” or the point at which studies in containment may proceed, in sub-Saharan African settings. First, “compliance” for research with novel or non-native living organisms was defined as the fulfillment of all legislative and regulatory requirements. This is not limited to regulations regarding use of transgenic organisms. Second, the concept of “colony utility” was related to the characteristics of laboratory colonies being produced so that results of studies may be validated across time, sites, and strains or technologies; so that the appropriate candidate strains are moved forward toward field studies. Third, the importance of achieving “defensible science” was recognized, including that study conclusions can be traced back to evidence, covering the concerns of various stakeholders over the long term. This, combined with good stewardship of resources and appropriate funding, covers a diverse set of criteria for declaring when “facilities readiness” has been attained. It is proposed that, despite the additional demands on time and resources, only with the balance of and rigorous achievement of each of these organizing themes can collaborative research into novel strategies in vector or pest control reliably progress past initial containment studies. 2018-01 2018-05-01T12:18:12Z 2018-05-01T12:18:12Z Journal Article https://hdl.handle.net/10568/92438 en Open Access Mary Ann Liebert Inc Quinlan, M. M., Birungi, J., Coulibaly, M.B., Diabaté, A., Facchinelli, L., Mukabana, W.R., Mutunga J.M., Nolan, T., Raymond, P. and Traoré, S.F. 2018. Containment studies of transgenic mosquitoes in disease endemic countries: The broad concept of facilities readiness. Vector-Borne and Zoonotic Diseases 18(1):14–20. |
| spellingShingle | disease control health livestock zoonoses Quinlan, M. Megan Birungi, Josephine Coulibaly, Mamadou B. Diabaté, Abdoulaye Facchinelli, Luca Mukabana, Wolfgang R. Mutunga James M. Nolan, Tony Raymond, Peter Traoré, Sékou F. Containment studies of transgenic mosquitoes in disease endemic countries: The broad concept of facilities readiness |
| title | Containment studies of transgenic mosquitoes in disease endemic countries: The broad concept of facilities readiness |
| title_full | Containment studies of transgenic mosquitoes in disease endemic countries: The broad concept of facilities readiness |
| title_fullStr | Containment studies of transgenic mosquitoes in disease endemic countries: The broad concept of facilities readiness |
| title_full_unstemmed | Containment studies of transgenic mosquitoes in disease endemic countries: The broad concept of facilities readiness |
| title_short | Containment studies of transgenic mosquitoes in disease endemic countries: The broad concept of facilities readiness |
| title_sort | containment studies of transgenic mosquitoes in disease endemic countries the broad concept of facilities readiness |
| topic | disease control health livestock zoonoses |
| url | https://hdl.handle.net/10568/92438 |
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