Complete avian malaria parasite genomes reveal features associated with lineage-specific evolution in birds and mammals
Avian malaria parasites are prevalent around the world and infect a wide diversity of bird species. Here, we report the sequencing and analysis of high-quality draft genome sequences for two avian malaria species, Plasmodium relictum and Plasmodium gallinaceum. We identify 50 genes that are specific...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
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Cold Spring Harbor Laboratory
2018
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/92065 |
| _version_ | 1855537720544198656 |
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| author | Böhme, U. Otto, T.D. Cotton, J.A. Steinbiss, S. Sanders, M. Oyola, Samuel O. Nicot, A. Gandon, S. Patra, K.P. Herd, C. Bushell, E. Modrzynska, K.K. Billker, O. Vinetz, J.M. Rivero, A. Newbold, C.J. Berriman, M. |
| author_browse | Berriman, M. Billker, O. Bushell, E. Böhme, U. Cotton, J.A. Gandon, S. Herd, C. Modrzynska, K.K. Newbold, C.J. Nicot, A. Otto, T.D. Oyola, Samuel O. Patra, K.P. Rivero, A. Sanders, M. Steinbiss, S. Vinetz, J.M. |
| author_facet | Böhme, U. Otto, T.D. Cotton, J.A. Steinbiss, S. Sanders, M. Oyola, Samuel O. Nicot, A. Gandon, S. Patra, K.P. Herd, C. Bushell, E. Modrzynska, K.K. Billker, O. Vinetz, J.M. Rivero, A. Newbold, C.J. Berriman, M. |
| author_sort | Böhme, U. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Avian malaria parasites are prevalent around the world and infect a wide diversity of bird species. Here, we report the sequencing and analysis of high-quality draft genome sequences for two avian malaria species, Plasmodium relictum and Plasmodium gallinaceum. We identify 50 genes that are specific to avian malaria, located in an otherwise conserved core of the genome that shares gene synteny with all other sequenced malaria genomes. Phylogenetic analysis suggests that the avian malaria species form an outgroup to the mammalian Plasmodium species, and using amino acid divergence between species, we estimate the avian- and mammalian-infective lineages diverged in the order of 10 million years ago. Consistent with their phylogenetic position, we identify orthologs of genes that had previously appeared to be restricted to the clades of parasites containing Plasmodium falciparum and Plasmodium vivax, the species with the greatest impact on human health. From these orthologs, we explore differential diversifying selection across the genus and show that the avian lineage is remarkable in the extent to which invasion-related genes are evolving. The subtelomeres of the P. relictum and P. gallinaceum genomes contain several novel gene families, including an expanded surf multigene family. We also identify an expansion of reticulocyte binding protein homologs in P. relictum, and within these proteins, we detect distinct regions that are specific to nonhuman primate, humans, rodent, and avian hosts. For the first time in the Plasmodium lineage, we find evidence of transposable elements, including several hundred fragments of LTR-retrotransposons in both species and an apparently complete LTR-retrotransposon in the genome of P. gallinaceum. |
| format | Journal Article |
| id | CGSpace92065 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| publisher | Cold Spring Harbor Laboratory |
| publisherStr | Cold Spring Harbor Laboratory |
| record_format | dspace |
| spelling | CGSpace920652023-03-18T10:58:00Z Complete avian malaria parasite genomes reveal features associated with lineage-specific evolution in birds and mammals Böhme, U. Otto, T.D. Cotton, J.A. Steinbiss, S. Sanders, M. Oyola, Samuel O. Nicot, A. Gandon, S. Patra, K.P. Herd, C. Bushell, E. Modrzynska, K.K. Billker, O. Vinetz, J.M. Rivero, A. Newbold, C.J. Berriman, M. genetics animal diseases malaria Avian malaria parasites are prevalent around the world and infect a wide diversity of bird species. Here, we report the sequencing and analysis of high-quality draft genome sequences for two avian malaria species, Plasmodium relictum and Plasmodium gallinaceum. We identify 50 genes that are specific to avian malaria, located in an otherwise conserved core of the genome that shares gene synteny with all other sequenced malaria genomes. Phylogenetic analysis suggests that the avian malaria species form an outgroup to the mammalian Plasmodium species, and using amino acid divergence between species, we estimate the avian- and mammalian-infective lineages diverged in the order of 10 million years ago. Consistent with their phylogenetic position, we identify orthologs of genes that had previously appeared to be restricted to the clades of parasites containing Plasmodium falciparum and Plasmodium vivax, the species with the greatest impact on human health. From these orthologs, we explore differential diversifying selection across the genus and show that the avian lineage is remarkable in the extent to which invasion-related genes are evolving. The subtelomeres of the P. relictum and P. gallinaceum genomes contain several novel gene families, including an expanded surf multigene family. We also identify an expansion of reticulocyte binding protein homologs in P. relictum, and within these proteins, we detect distinct regions that are specific to nonhuman primate, humans, rodent, and avian hosts. For the first time in the Plasmodium lineage, we find evidence of transposable elements, including several hundred fragments of LTR-retrotransposons in both species and an apparently complete LTR-retrotransposon in the genome of P. gallinaceum. 2018-04 2018-04-12T19:30:25Z 2018-04-12T19:30:25Z Journal Article https://hdl.handle.net/10568/92065 en Open Access Cold Spring Harbor Laboratory Böhme, U., Otto, T.D., Cotton, J.A., Steinbiss, S., Sanders, M., Oyola, S.O., Nicot, A., Gandon, S., Patra, K.P., Herd, C., Bushell, E., Modrzynska, K.K., Billker, O., Vinetz, J.M., Rivero, A., Newbold, C.I. and Berriman, M. 2018. Complete avian malaria parasite genomes reveal features associated with lineage-specific evolution in birds and mammals. Genome Research 28(4):547-560. |
| spellingShingle | genetics animal diseases malaria Böhme, U. Otto, T.D. Cotton, J.A. Steinbiss, S. Sanders, M. Oyola, Samuel O. Nicot, A. Gandon, S. Patra, K.P. Herd, C. Bushell, E. Modrzynska, K.K. Billker, O. Vinetz, J.M. Rivero, A. Newbold, C.J. Berriman, M. Complete avian malaria parasite genomes reveal features associated with lineage-specific evolution in birds and mammals |
| title | Complete avian malaria parasite genomes reveal features associated with lineage-specific evolution in birds and mammals |
| title_full | Complete avian malaria parasite genomes reveal features associated with lineage-specific evolution in birds and mammals |
| title_fullStr | Complete avian malaria parasite genomes reveal features associated with lineage-specific evolution in birds and mammals |
| title_full_unstemmed | Complete avian malaria parasite genomes reveal features associated with lineage-specific evolution in birds and mammals |
| title_short | Complete avian malaria parasite genomes reveal features associated with lineage-specific evolution in birds and mammals |
| title_sort | complete avian malaria parasite genomes reveal features associated with lineage specific evolution in birds and mammals |
| topic | genetics animal diseases malaria |
| url | https://hdl.handle.net/10568/92065 |
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