Whole genome detection of signature of positive selection in African cattle reveals selection for thermotolerance
As African indigenous cattle evolved in a hot tropical climate, they have developed an inherent thermotolerance; survival mechanisms include a light‐colored and shiny coat, increased sweating, and cellular and molecular mechanisms to cope with high environmental temperature. Here, we report the posi...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Wiley
2017
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/90521 |
| _version_ | 1855515605529001984 |
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| author | Taye, M. Wonseok Lee Caetano-Anolles, Kelsey Dessie, Tadelle Hanotte, Olivier H. Okeyo Mwai, Ally Kemp, Stephen J. Seoae Cho Sung Jong Oh Hak-Kyo Lee Heebal Kim |
| author_browse | Caetano-Anolles, Kelsey Dessie, Tadelle Hak-Kyo Lee Hanotte, Olivier H. Heebal Kim Kemp, Stephen J. Okeyo Mwai, Ally Seoae Cho Sung Jong Oh Taye, M. Wonseok Lee |
| author_facet | Taye, M. Wonseok Lee Caetano-Anolles, Kelsey Dessie, Tadelle Hanotte, Olivier H. Okeyo Mwai, Ally Kemp, Stephen J. Seoae Cho Sung Jong Oh Hak-Kyo Lee Heebal Kim |
| author_sort | Taye, M. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | As African indigenous cattle evolved in a hot tropical climate, they have developed an inherent thermotolerance; survival mechanisms include a light‐colored and shiny coat, increased sweating, and cellular and molecular mechanisms to cope with high environmental temperature. Here, we report the positive selection signature of genes in African cattle breeds which contribute for their heat tolerance mechanisms. We compared the genomes of five indigenous African cattle breeds with the genomes of four commercial cattle breeds using cross‐population composite likelihood ratio (XP‐CLR) and cross‐population extended haplotype homozygosity (XP‐EHH) statistical methods. We identified 296 (XP‐EHH) and 327 (XP‐CLR) positively selected genes. Gene ontology analysis resulted in 41 biological process terms and six Kyoto Encyclopedia of Genes and Genomes pathways. Several genes and pathways were found to be involved in oxidative stress response, osmotic stress response, heat shock response, hair and skin properties, sweat gland development and sweating, feed intake and metabolism, and reproduction functions. The genes and pathways identified directly or indirectly contribute to the superior heat tolerance mechanisms in African cattle populations. The result will improve our understanding of the biological mechanisms of heat tolerance in African cattle breeds and opens an avenue for further study. |
| format | Journal Article |
| id | CGSpace90521 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| publisher | Wiley |
| publisherStr | Wiley |
| record_format | dspace |
| spelling | CGSpace905212024-05-01T08:15:21Z Whole genome detection of signature of positive selection in African cattle reveals selection for thermotolerance Taye, M. Wonseok Lee Caetano-Anolles, Kelsey Dessie, Tadelle Hanotte, Olivier H. Okeyo Mwai, Ally Kemp, Stephen J. Seoae Cho Sung Jong Oh Hak-Kyo Lee Heebal Kim cattle livestock genomes research As African indigenous cattle evolved in a hot tropical climate, they have developed an inherent thermotolerance; survival mechanisms include a light‐colored and shiny coat, increased sweating, and cellular and molecular mechanisms to cope with high environmental temperature. Here, we report the positive selection signature of genes in African cattle breeds which contribute for their heat tolerance mechanisms. We compared the genomes of five indigenous African cattle breeds with the genomes of four commercial cattle breeds using cross‐population composite likelihood ratio (XP‐CLR) and cross‐population extended haplotype homozygosity (XP‐EHH) statistical methods. We identified 296 (XP‐EHH) and 327 (XP‐CLR) positively selected genes. Gene ontology analysis resulted in 41 biological process terms and six Kyoto Encyclopedia of Genes and Genomes pathways. Several genes and pathways were found to be involved in oxidative stress response, osmotic stress response, heat shock response, hair and skin properties, sweat gland development and sweating, feed intake and metabolism, and reproduction functions. The genes and pathways identified directly or indirectly contribute to the superior heat tolerance mechanisms in African cattle populations. The result will improve our understanding of the biological mechanisms of heat tolerance in African cattle breeds and opens an avenue for further study. 2017-12 2018-01-18T13:46:38Z 2018-01-18T13:46:38Z Journal Article https://hdl.handle.net/10568/90521 en Open Access Wiley Taye, M., Wonseok Lee, Caetano-Anolles, K., Dessie, T., Hanotte, O., Ally Mwai, O., Kemp, S., Seoae Cho, Sung Jong Oh, Hak-Kyo Lee, Heebal Kim. 2017. Whole genome detection of signature of positive selection in African cattle reveals selection for thermotolerance. Animal Science Journal 88(12): 1889–1901 |
| spellingShingle | cattle livestock genomes research Taye, M. Wonseok Lee Caetano-Anolles, Kelsey Dessie, Tadelle Hanotte, Olivier H. Okeyo Mwai, Ally Kemp, Stephen J. Seoae Cho Sung Jong Oh Hak-Kyo Lee Heebal Kim Whole genome detection of signature of positive selection in African cattle reveals selection for thermotolerance |
| title | Whole genome detection of signature of positive selection in African cattle reveals selection for thermotolerance |
| title_full | Whole genome detection of signature of positive selection in African cattle reveals selection for thermotolerance |
| title_fullStr | Whole genome detection of signature of positive selection in African cattle reveals selection for thermotolerance |
| title_full_unstemmed | Whole genome detection of signature of positive selection in African cattle reveals selection for thermotolerance |
| title_short | Whole genome detection of signature of positive selection in African cattle reveals selection for thermotolerance |
| title_sort | whole genome detection of signature of positive selection in african cattle reveals selection for thermotolerance |
| topic | cattle livestock genomes research |
| url | https://hdl.handle.net/10568/90521 |
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