Serological and spatial analysis of alphavirus and flavivirus prevalence and risk factors in a rural community in western Kenya
Alphaviruses, such as chikungunya virus, and flaviviruses, such as dengue virus, are (re)-emerging arboviruses that are endemic in tropical environments. In Africa, arbovirus infections are often undiagnosed and unreported, with febrile illnesses often assumed to be malaria. This cross-sectional stu...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
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Public Library of Science
2017
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/89176 |
| _version_ | 1855535612577185792 |
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| author | Grossi-Soyster, E.N. Cook, Elizabeth A.J. Glanville, William A. de Thomas, Lian F. Krystosik, A.R. Lee, J. Wamae, C.N. Kariuki, S. Fèvre, Eric M. LaBeaud, A.D. |
| author_browse | Cook, Elizabeth A.J. Fèvre, Eric M. Glanville, William A. de Grossi-Soyster, E.N. Kariuki, S. Krystosik, A.R. LaBeaud, A.D. Lee, J. Thomas, Lian F. Wamae, C.N. |
| author_facet | Grossi-Soyster, E.N. Cook, Elizabeth A.J. Glanville, William A. de Thomas, Lian F. Krystosik, A.R. Lee, J. Wamae, C.N. Kariuki, S. Fèvre, Eric M. LaBeaud, A.D. |
| author_sort | Grossi-Soyster, E.N. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Alphaviruses, such as chikungunya virus, and flaviviruses, such as dengue virus, are (re)-emerging arboviruses that are endemic in tropical environments. In Africa, arbovirus infections are often undiagnosed and unreported, with febrile illnesses often assumed to be malaria. This cross-sectional study aimed to characterize the seroprevalence of alphaviruses and flaviviruses among children (ages 5–14, n = 250) and adults (ages 15 ≥ 75, n = 250) in western Kenya. Risk factors for seropositivity were explored using Lasso regression. Overall, 67% of participants showed alphavirus seropositivity (CI95 63%–70%), and 1.6% of participants showed flavivirus seropositivity (CI95 0.7%–3%). Children aged 10–14 were more likely to be seropositive to an alphavirus than adults (p < 0.001), suggesting a recent transmission period. Alphavirus and flavivirus seropositivity was detected in the youngest participants (age 5–9), providing evidence of inter-epidemic transmission. Demographic variables that were significantly different amongst those with previous infection versus those without infection included age, education level, and occupation. Behavioral and environmental variables significantly different amongst those in with previous infection to those without infection included taking animals for grazing, fishing, and recent village flooding. Experience of recent fever was also found to be a significant indicator of infection (p = 0.027). These results confirm alphavirus and flavivirus exposure in western Kenya, while illustrating significantly higher alphavirus transmission compared to previous studies. |
| format | Journal Article |
| id | CGSpace89176 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| publisher | Public Library of Science |
| publisherStr | Public Library of Science |
| record_format | dspace |
| spelling | CGSpace891762023-12-08T19:36:04Z Serological and spatial analysis of alphavirus and flavivirus prevalence and risk factors in a rural community in western Kenya Grossi-Soyster, E.N. Cook, Elizabeth A.J. Glanville, William A. de Thomas, Lian F. Krystosik, A.R. Lee, J. Wamae, C.N. Kariuki, S. Fèvre, Eric M. LaBeaud, A.D. environment health Alphaviruses, such as chikungunya virus, and flaviviruses, such as dengue virus, are (re)-emerging arboviruses that are endemic in tropical environments. In Africa, arbovirus infections are often undiagnosed and unreported, with febrile illnesses often assumed to be malaria. This cross-sectional study aimed to characterize the seroprevalence of alphaviruses and flaviviruses among children (ages 5–14, n = 250) and adults (ages 15 ≥ 75, n = 250) in western Kenya. Risk factors for seropositivity were explored using Lasso regression. Overall, 67% of participants showed alphavirus seropositivity (CI95 63%–70%), and 1.6% of participants showed flavivirus seropositivity (CI95 0.7%–3%). Children aged 10–14 were more likely to be seropositive to an alphavirus than adults (p < 0.001), suggesting a recent transmission period. Alphavirus and flavivirus seropositivity was detected in the youngest participants (age 5–9), providing evidence of inter-epidemic transmission. Demographic variables that were significantly different amongst those with previous infection versus those without infection included age, education level, and occupation. Behavioral and environmental variables significantly different amongst those in with previous infection to those without infection included taking animals for grazing, fishing, and recent village flooding. Experience of recent fever was also found to be a significant indicator of infection (p = 0.027). These results confirm alphavirus and flavivirus exposure in western Kenya, while illustrating significantly higher alphavirus transmission compared to previous studies. 2017-10-17 2017-11-01T12:18:37Z 2017-11-01T12:18:37Z Journal Article https://hdl.handle.net/10568/89176 en Open Access Public Library of Science Grossi-Soyster, E.N., Cook, E.A.J., Glanville, W.A. de, Thomas, L.F., Krystosik, A.R., Lee, J., Wamae, C.N., Kariuki, S., Fèvre, E.M. and LaBeaud, A.D. 2017. Serological and spatial analysis of alphavirus and flavivirus prevalence and risk factors in a rural community in western Kenya. PLOS Neglected Tropical Diseases 11(10): e0005998. |
| spellingShingle | environment health Grossi-Soyster, E.N. Cook, Elizabeth A.J. Glanville, William A. de Thomas, Lian F. Krystosik, A.R. Lee, J. Wamae, C.N. Kariuki, S. Fèvre, Eric M. LaBeaud, A.D. Serological and spatial analysis of alphavirus and flavivirus prevalence and risk factors in a rural community in western Kenya |
| title | Serological and spatial analysis of alphavirus and flavivirus prevalence and risk factors in a rural community in western Kenya |
| title_full | Serological and spatial analysis of alphavirus and flavivirus prevalence and risk factors in a rural community in western Kenya |
| title_fullStr | Serological and spatial analysis of alphavirus and flavivirus prevalence and risk factors in a rural community in western Kenya |
| title_full_unstemmed | Serological and spatial analysis of alphavirus and flavivirus prevalence and risk factors in a rural community in western Kenya |
| title_short | Serological and spatial analysis of alphavirus and flavivirus prevalence and risk factors in a rural community in western Kenya |
| title_sort | serological and spatial analysis of alphavirus and flavivirus prevalence and risk factors in a rural community in western kenya |
| topic | environment health |
| url | https://hdl.handle.net/10568/89176 |
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