Approaches to vaccination against Theileria parva and Theileria annulata
Despite having different cell tropism, the pathogenesis and immunobiology of the diseases caused by Theileria parva and Theileria annulata are remarkably similar. Live vaccines have been available for both parasites for over 40 years, but although they provide strong protection, practical disadvanta...
| Main Authors: | , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Wiley
2016
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/80004 |
| _version_ | 1855528580047437824 |
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| author | Nene, Vishvanath M. Morrison, W. Ivan |
| author_browse | Morrison, W. Ivan Nene, Vishvanath M. |
| author_facet | Nene, Vishvanath M. Morrison, W. Ivan |
| author_sort | Nene, Vishvanath M. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Despite having different cell tropism, the pathogenesis and immunobiology of the diseases caused by Theileria parva and Theileria annulata are remarkably similar. Live vaccines have been available for both parasites for over 40 years, but although they provide strong protection, practical disadvantages have limited their widespread application. Efforts to develop alternative vaccines using defined parasite antigens have focused on the sporozoite and intracellular schizont stages of the parasites. Experimental vaccination studies using viral vectors expressing T. parva schizont antigens and T. parva and T. annulata sporozoite antigens incorporated in adjuvant have, in each case, demonstrated protection against parasite challenge in a proportion of vaccinated animals. Current work is investigating alternative antigen delivery systems in an attempt to improve the levels of protection. The genome architecture and protein-coding capacity of T. parva and T. annulata are remarkably similar. The major sporozoite surface antigen in both species and most of the schizont antigens are encoded by orthologous genes. The former have been shown to induce species cross-reactive neutralizing antibodies, and comparison of the schizont antigen orthologues has demonstrated that some of them display high levels of sequence conservation. Hence, advances in development of subunit vaccines against one parasite species are likely to be readily applicable to the other. |
| format | Journal Article |
| id | CGSpace80004 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2016 |
| publishDateRange | 2016 |
| publishDateSort | 2016 |
| publisher | Wiley |
| publisherStr | Wiley |
| record_format | dspace |
| spelling | CGSpace800042024-01-17T12:58:34Z Approaches to vaccination against Theileria parva and Theileria annulata Nene, Vishvanath M. Morrison, W. Ivan theileria cattle animal diseases vaccines disease control east coast fever Despite having different cell tropism, the pathogenesis and immunobiology of the diseases caused by Theileria parva and Theileria annulata are remarkably similar. Live vaccines have been available for both parasites for over 40 years, but although they provide strong protection, practical disadvantages have limited their widespread application. Efforts to develop alternative vaccines using defined parasite antigens have focused on the sporozoite and intracellular schizont stages of the parasites. Experimental vaccination studies using viral vectors expressing T. parva schizont antigens and T. parva and T. annulata sporozoite antigens incorporated in adjuvant have, in each case, demonstrated protection against parasite challenge in a proportion of vaccinated animals. Current work is investigating alternative antigen delivery systems in an attempt to improve the levels of protection. The genome architecture and protein-coding capacity of T. parva and T. annulata are remarkably similar. The major sporozoite surface antigen in both species and most of the schizont antigens are encoded by orthologous genes. The former have been shown to induce species cross-reactive neutralizing antibodies, and comparison of the schizont antigen orthologues has demonstrated that some of them display high levels of sequence conservation. Hence, advances in development of subunit vaccines against one parasite species are likely to be readily applicable to the other. 2016-12 2017-02-23T09:29:31Z 2017-02-23T09:29:31Z Journal Article https://hdl.handle.net/10568/80004 en Open Access Wiley Nene, V. and Morrison, W.I. 2016. Approaches to vaccination against Theileria parva and Theileria annulata. Parasite Immunology 38(12):724-734. |
| spellingShingle | theileria cattle animal diseases vaccines disease control east coast fever Nene, Vishvanath M. Morrison, W. Ivan Approaches to vaccination against Theileria parva and Theileria annulata |
| title | Approaches to vaccination against Theileria parva and Theileria annulata |
| title_full | Approaches to vaccination against Theileria parva and Theileria annulata |
| title_fullStr | Approaches to vaccination against Theileria parva and Theileria annulata |
| title_full_unstemmed | Approaches to vaccination against Theileria parva and Theileria annulata |
| title_short | Approaches to vaccination against Theileria parva and Theileria annulata |
| title_sort | approaches to vaccination against theileria parva and theileria annulata |
| topic | theileria cattle animal diseases vaccines disease control east coast fever |
| url | https://hdl.handle.net/10568/80004 |
| work_keys_str_mv | AT nenevishvanathm approachestovaccinationagainsttheileriaparvaandtheileriaannulata AT morrisonwivan approachestovaccinationagainsttheileriaparvaandtheileriaannulata |