A Fosmid pool-based next generation sequencing approach to haplotype-resolve whole genomes
Haplotype resolution of human genomes is essential to describe and interpret genetic variation and its impact on biology and disease. Our approach to haplotyping relies on converting genomic DNA into a fosmid library, which represents the entire diploid genome as a collection of haploid DNA clones o...
| Main Authors: | , , , , , |
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| Format: | Book Chapter |
| Language: | Inglés |
| Published: |
Springer
2017
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/79937 |
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