Theileria-transformed bovine leukocytes have cancer hallmarks
The genus Theileria includes tick-transmitted apicomplexan parasites of ruminants with substantial economic impact in endemic countries. Some species, including Theileria parva and Theileria annulata, infect leukocytes where they induce phenotypes that are shared with some cancers, most notably immo...
| Autores principales: | , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier
2015
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/77696 |
| _version_ | 1855539423635046400 |
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| author | Tretina, Kyle Gotia, H.T. Mann, D.J. Silva, Joana C. |
| author_browse | Gotia, H.T. Mann, D.J. Silva, Joana C. Tretina, Kyle |
| author_facet | Tretina, Kyle Gotia, H.T. Mann, D.J. Silva, Joana C. |
| author_sort | Tretina, Kyle |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | The genus Theileria includes tick-transmitted apicomplexan parasites of ruminants with substantial economic impact in endemic countries. Some species, including Theileria parva and Theileria annulata, infect leukocytes where they induce phenotypes that are shared with some cancers, most notably immortalization, hyperproliferation, and dissemination. Despite considerable research into the affected host signaling pathways, the parasite proteins directly responsible for these host phenotypes remain unknown. In this review we outline current knowledge on the manipulation of host cells by transformation-inducing Theileria, and we propose that comparisons between cancer biology and host–Theileria interactions can reveal chemotherapeutic targets against Theileria-induced pathogenesis based on cancer treatment approaches. |
| format | Journal Article |
| id | CGSpace77696 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | CGSpace776962024-01-12T10:00:54Z Theileria-transformed bovine leukocytes have cancer hallmarks Tretina, Kyle Gotia, H.T. Mann, D.J. Silva, Joana C. theileria cattle animal diseases vaccines disease control east coast fever The genus Theileria includes tick-transmitted apicomplexan parasites of ruminants with substantial economic impact in endemic countries. Some species, including Theileria parva and Theileria annulata, infect leukocytes where they induce phenotypes that are shared with some cancers, most notably immortalization, hyperproliferation, and dissemination. Despite considerable research into the affected host signaling pathways, the parasite proteins directly responsible for these host phenotypes remain unknown. In this review we outline current knowledge on the manipulation of host cells by transformation-inducing Theileria, and we propose that comparisons between cancer biology and host–Theileria interactions can reveal chemotherapeutic targets against Theileria-induced pathogenesis based on cancer treatment approaches. 2015-07 2016-11-10T15:01:32Z 2016-11-10T15:01:32Z Journal Article https://hdl.handle.net/10568/77696 en Open Access Elsevier Tretina, K., Gotia, H.T., Mann, D.J. and Silva, J.C. 2015. Theileria-transformed bovine leukocytes have cancer hallmarks. Trends in Parasitology 31(7):306–314. |
| spellingShingle | theileria cattle animal diseases vaccines disease control east coast fever Tretina, Kyle Gotia, H.T. Mann, D.J. Silva, Joana C. Theileria-transformed bovine leukocytes have cancer hallmarks |
| title | Theileria-transformed bovine leukocytes have cancer hallmarks |
| title_full | Theileria-transformed bovine leukocytes have cancer hallmarks |
| title_fullStr | Theileria-transformed bovine leukocytes have cancer hallmarks |
| title_full_unstemmed | Theileria-transformed bovine leukocytes have cancer hallmarks |
| title_short | Theileria-transformed bovine leukocytes have cancer hallmarks |
| title_sort | theileria transformed bovine leukocytes have cancer hallmarks |
| topic | theileria cattle animal diseases vaccines disease control east coast fever |
| url | https://hdl.handle.net/10568/77696 |
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