Whole-genome sequencing of native sheep provides insights into rapid adaptations to extreme environments
Global climate change has a significant effect on extreme environments and a profound influence on species survival. However, little is known of the genome-wide pattern of livestock adaptations to extreme environments over a short time frame following domestication. Sheep (Ovis aries) have become we...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Oxford University Press
2016
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/77317 |
| _version_ | 1855524048320069632 |
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| author | Ji Yang Wen-Rong Li Feng-Hua Lv San-Gang He Shi-Lin Tian Wei-Feng Peng Ya-Wei Sun Yong-Xin Zhao Xiao-Long Tu Min Zhang Xing-Long Xie Yu-Tao Wang Jin-Quan Li Yong-Gang Liu Zhi-Qiang Shen Feng Wang Guang-Jian Liu Hong-Feng Lu Kantanen, Juha Han Jianlin Meng-Hua Li Ming-Jun Liu |
| author_browse | Feng Wang Feng-Hua Lv Guang-Jian Liu Han Jianlin Hong-Feng Lu Ji Yang Jin-Quan Li Kantanen, Juha Meng-Hua Li Min Zhang Ming-Jun Liu San-Gang He Shi-Lin Tian Wei-Feng Peng Wen-Rong Li Xiao-Long Tu Xing-Long Xie Ya-Wei Sun Yong-Gang Liu Yong-Xin Zhao Yu-Tao Wang Zhi-Qiang Shen |
| author_facet | Ji Yang Wen-Rong Li Feng-Hua Lv San-Gang He Shi-Lin Tian Wei-Feng Peng Ya-Wei Sun Yong-Xin Zhao Xiao-Long Tu Min Zhang Xing-Long Xie Yu-Tao Wang Jin-Quan Li Yong-Gang Liu Zhi-Qiang Shen Feng Wang Guang-Jian Liu Hong-Feng Lu Kantanen, Juha Han Jianlin Meng-Hua Li Ming-Jun Liu |
| author_sort | Ji Yang |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Global climate change has a significant effect on extreme environments and a profound influence on species survival. However, little is known of the genome-wide pattern of livestock adaptations to extreme environments over a short time frame following domestication. Sheep (Ovis aries) have become well adapted to a diverse range of agroecological zones, including certain extreme environments (e.g., plateaus and deserts), during their post-domestication (approximately 8–9 kya) migration and differentiation. Here, we generated whole-genome sequences from 77 native sheep, with an average effective sequencing depth of ∼5× for 75 samples and ∼42× for 2 samples. Comparative genomic analyses among sheep in contrasting environments, that is, plateau (>4,000 m above sea level) versus lowland (<100 m), high-altitude region (>1500 m) versus low-altitude region (<1300 m), desert (<10 mm average annual precipitation) versus highly humid region (>600 mm), and arid zone (<400 mm) versus humid zone (>400 mm), detected a novel set of candidate genes as well as pathways and GO categories that are putatively associated with hypoxia responses at high altitudes and water reabsorption in arid environments. In addition, candidate genes and GO terms functionally related to energy metabolism and body size variations were identified. This study offers novel insights into rapid genomic adaptations to extreme environments in sheep and other animals, and provides a valuable resource for future research on livestock breeding in response to climate change. |
| format | Journal Article |
| id | CGSpace77317 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2016 |
| publishDateRange | 2016 |
| publishDateSort | 2016 |
| publisher | Oxford University Press |
| publisherStr | Oxford University Press |
| record_format | dspace |
| spelling | CGSpace773172025-11-12T04:27:16Z Whole-genome sequencing of native sheep provides insights into rapid adaptations to extreme environments Ji Yang Wen-Rong Li Feng-Hua Lv San-Gang He Shi-Lin Tian Wei-Feng Peng Ya-Wei Sun Yong-Xin Zhao Xiao-Long Tu Min Zhang Xing-Long Xie Yu-Tao Wang Jin-Quan Li Yong-Gang Liu Zhi-Qiang Shen Feng Wang Guang-Jian Liu Hong-Feng Lu Kantanen, Juha Han Jianlin Meng-Hua Li Ming-Jun Liu animal production sheep climate change Global climate change has a significant effect on extreme environments and a profound influence on species survival. However, little is known of the genome-wide pattern of livestock adaptations to extreme environments over a short time frame following domestication. Sheep (Ovis aries) have become well adapted to a diverse range of agroecological zones, including certain extreme environments (e.g., plateaus and deserts), during their post-domestication (approximately 8–9 kya) migration and differentiation. Here, we generated whole-genome sequences from 77 native sheep, with an average effective sequencing depth of ∼5× for 75 samples and ∼42× for 2 samples. Comparative genomic analyses among sheep in contrasting environments, that is, plateau (>4,000 m above sea level) versus lowland (<100 m), high-altitude region (>1500 m) versus low-altitude region (<1300 m), desert (<10 mm average annual precipitation) versus highly humid region (>600 mm), and arid zone (<400 mm) versus humid zone (>400 mm), detected a novel set of candidate genes as well as pathways and GO categories that are putatively associated with hypoxia responses at high altitudes and water reabsorption in arid environments. In addition, candidate genes and GO terms functionally related to energy metabolism and body size variations were identified. This study offers novel insights into rapid genomic adaptations to extreme environments in sheep and other animals, and provides a valuable resource for future research on livestock breeding in response to climate change. 2016-10 2016-10-14T13:04:40Z 2016-10-14T13:04:40Z Journal Article https://hdl.handle.net/10568/77317 en Open Access application/pdf Oxford University Press Yu-Tao Wang, Jin-Quan Li, Yong-Gang Liu, Zhi-Qiang Shen, Feng Wang, Guang-Jian Liu, Hong-Feng Lu, Juha Kantanen, Jian-Lin Han, Meng-Hua Li and Ming-Jun Liu. 2016. Whole-genome sequencing of native sheep provides insights into rapid adaptations to extreme environments. Molecular Biology and Evolution 33(10):2576-2592. |
| spellingShingle | animal production sheep climate change Ji Yang Wen-Rong Li Feng-Hua Lv San-Gang He Shi-Lin Tian Wei-Feng Peng Ya-Wei Sun Yong-Xin Zhao Xiao-Long Tu Min Zhang Xing-Long Xie Yu-Tao Wang Jin-Quan Li Yong-Gang Liu Zhi-Qiang Shen Feng Wang Guang-Jian Liu Hong-Feng Lu Kantanen, Juha Han Jianlin Meng-Hua Li Ming-Jun Liu Whole-genome sequencing of native sheep provides insights into rapid adaptations to extreme environments |
| title | Whole-genome sequencing of native sheep provides insights into rapid adaptations to extreme environments |
| title_full | Whole-genome sequencing of native sheep provides insights into rapid adaptations to extreme environments |
| title_fullStr | Whole-genome sequencing of native sheep provides insights into rapid adaptations to extreme environments |
| title_full_unstemmed | Whole-genome sequencing of native sheep provides insights into rapid adaptations to extreme environments |
| title_short | Whole-genome sequencing of native sheep provides insights into rapid adaptations to extreme environments |
| title_sort | whole genome sequencing of native sheep provides insights into rapid adaptations to extreme environments |
| topic | animal production sheep climate change |
| url | https://hdl.handle.net/10568/77317 |
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