Interindividual variation in DNA methylation at a putative POMC metastable epiallele is associated with obesity

The estimated heritability of human BMI is close to 75%, but identified genetic variants explain only a small fraction of interindividual body-weight variation. Inherited epigenetic variants identified in mouse models named "metastable epialleles" could in principle explain this "missing heritabilit...

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Bibliographic Details

Main Authors:	Kühnen, P., Handke, D., Waterland, R.A., Hennig, B.J., Silver, M., Fulford, A.J., Domínguez Salas, Paula, Moore, S.E., Prentice, A.M., Spranger, J., Hinney, A., Hebebrand, J., Heppner, F.L., Walzer, L., Grötzinger, C., Gromoll, J., Wiegand, S., Grüters, A., Krude, H.
Format:	Journal Article
Language:	Inglés
Published:	Elsevier 2016
Subjects:	health
Online Access:	https://hdl.handle.net/10568/77018