Associations between common variants in iron-related genes with haematological traits in populations of African ancestry
Background Large genome-wide association (GWA) studies of European ancestry individuals have identified multiple genetic variants influencing iron status. Studies on the generalizability of these associations to African ancestry populations have been limited. These studies are important given intere...
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Public Library of Science
2016
|
| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/76253 |
| _version_ | 1855524801575124992 |
|---|---|
| author | Gichohi-Wainaina, Wanjiku N. Tanaka, Toshiko Towers, G. Wayne Verhoef, Hans Veenemans, Jacobien Talsma, Elise F. Harryvan, Jan Boekschoten, Mark V. Feskens, Edith J.M. Melse-Boonstra, Alida |
| author_browse | Boekschoten, Mark V. Feskens, Edith J.M. Gichohi-Wainaina, Wanjiku N. Harryvan, Jan Melse-Boonstra, Alida Talsma, Elise F. Tanaka, Toshiko Towers, G. Wayne Veenemans, Jacobien Verhoef, Hans |
| author_facet | Gichohi-Wainaina, Wanjiku N. Tanaka, Toshiko Towers, G. Wayne Verhoef, Hans Veenemans, Jacobien Talsma, Elise F. Harryvan, Jan Boekschoten, Mark V. Feskens, Edith J.M. Melse-Boonstra, Alida |
| author_sort | Gichohi-Wainaina, Wanjiku N. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Background
Large genome-wide association (GWA) studies of European ancestry individuals have identified multiple genetic variants influencing iron status. Studies on the generalizability of these associations to African ancestry populations have been limited. These studies are important given interethnic differences in iron status and the disproportionate burden of iron deficiency among African ancestry populations.
Methods
We tested the associations of 20 previously identified iron status-associated single nucleotide polymorphisms (SNPs) in 628 Kenyans, 609 Tanzanians, 608 South Africans and 228 African Americans. In each study, we examined the associations present between 20 SNPs with ferritin and haemoglobin, adjusting for age, sex and CRP levels.
Results
In the meta analysis including all 4 African ancestry cohorts, we replicated previously reported associations with lowered haemoglobin concentrations for rs2413450 (β = -0.19, P = 0.02) and rs4820268 (β = -0.16, P = 0.04) in TMPRSS6. An association with increased ferritin concentrations was also confirmed for rs1867504 in TF (β = 1.04, P = <0.0001) in the meta analysis including the African cohorts only.
Conclusions
In all meta analyses, we only replicated 4 of the 20 single nucleotide polymorphisms reported to be associated with iron status in large GWA studies of European ancestry individuals. While there is now evidence for the associations of a number of genetic variants with iron status in both European and African ancestry populations, the considerable lack of concordance highlights the importance of continued ancestry-specific studies to elucidate the genetic underpinnings of iron status in ethnically diverse populations. |
| format | Journal Article |
| id | CGSpace76253 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2016 |
| publishDateRange | 2016 |
| publishDateSort | 2016 |
| publisher | Public Library of Science |
| publisherStr | Public Library of Science |
| record_format | dspace |
| spelling | CGSpace762532025-03-13T09:44:14Z Associations between common variants in iron-related genes with haematological traits in populations of African ancestry Gichohi-Wainaina, Wanjiku N. Tanaka, Toshiko Towers, G. Wayne Verhoef, Hans Veenemans, Jacobien Talsma, Elise F. Harryvan, Jan Boekschoten, Mark V. Feskens, Edith J.M. Melse-Boonstra, Alida diet ferritin genotypes deficiencies iron inflammation population genetics genomics ferritín genotipos hierro inflamación genética de poblaciones genómica Background Large genome-wide association (GWA) studies of European ancestry individuals have identified multiple genetic variants influencing iron status. Studies on the generalizability of these associations to African ancestry populations have been limited. These studies are important given interethnic differences in iron status and the disproportionate burden of iron deficiency among African ancestry populations. Methods We tested the associations of 20 previously identified iron status-associated single nucleotide polymorphisms (SNPs) in 628 Kenyans, 609 Tanzanians, 608 South Africans and 228 African Americans. In each study, we examined the associations present between 20 SNPs with ferritin and haemoglobin, adjusting for age, sex and CRP levels. Results In the meta analysis including all 4 African ancestry cohorts, we replicated previously reported associations with lowered haemoglobin concentrations for rs2413450 (β = -0.19, P = 0.02) and rs4820268 (β = -0.16, P = 0.04) in TMPRSS6. An association with increased ferritin concentrations was also confirmed for rs1867504 in TF (β = 1.04, P = <0.0001) in the meta analysis including the African cohorts only. Conclusions In all meta analyses, we only replicated 4 of the 20 single nucleotide polymorphisms reported to be associated with iron status in large GWA studies of European ancestry individuals. While there is now evidence for the associations of a number of genetic variants with iron status in both European and African ancestry populations, the considerable lack of concordance highlights the importance of continued ancestry-specific studies to elucidate the genetic underpinnings of iron status in ethnically diverse populations. 2016-06-22 2016-07-22T23:14:58Z 2016-07-22T23:14:58Z Journal Article https://hdl.handle.net/10568/76253 en Open Access Public Library of Science Gichohi-Wainaina, Wanjiku N.; Tanaka, Toshiko; Towers, G. Wayne; Verhoef, Hans; Veenemans, Jacobien; Talsma, Elise; Harryvan, Jan; Boekschoten, Mark V.; Feskens, Edith J.; Melse-Boonstra, Alida. 2016. Associations between common variants in iron-related genes with haematological traits in populations of African ancestry . PLoS ONE 11(6): e0157996. |
| spellingShingle | diet ferritin genotypes deficiencies iron inflammation population genetics genomics ferritín genotipos hierro inflamación genética de poblaciones genómica Gichohi-Wainaina, Wanjiku N. Tanaka, Toshiko Towers, G. Wayne Verhoef, Hans Veenemans, Jacobien Talsma, Elise F. Harryvan, Jan Boekschoten, Mark V. Feskens, Edith J.M. Melse-Boonstra, Alida Associations between common variants in iron-related genes with haematological traits in populations of African ancestry |
| title | Associations between common variants in iron-related genes with haematological traits in populations of African ancestry |
| title_full | Associations between common variants in iron-related genes with haematological traits in populations of African ancestry |
| title_fullStr | Associations between common variants in iron-related genes with haematological traits in populations of African ancestry |
| title_full_unstemmed | Associations between common variants in iron-related genes with haematological traits in populations of African ancestry |
| title_short | Associations between common variants in iron-related genes with haematological traits in populations of African ancestry |
| title_sort | associations between common variants in iron related genes with haematological traits in populations of african ancestry |
| topic | diet ferritin genotypes deficiencies iron inflammation population genetics genomics ferritín genotipos hierro inflamación genética de poblaciones genómica |
| url | https://hdl.handle.net/10568/76253 |
| work_keys_str_mv | AT gichohiwainainawanjikun associationsbetweencommonvariantsinironrelatedgeneswithhaematologicaltraitsinpopulationsofafricanancestry AT tanakatoshiko associationsbetweencommonvariantsinironrelatedgeneswithhaematologicaltraitsinpopulationsofafricanancestry AT towersgwayne associationsbetweencommonvariantsinironrelatedgeneswithhaematologicaltraitsinpopulationsofafricanancestry AT verhoefhans associationsbetweencommonvariantsinironrelatedgeneswithhaematologicaltraitsinpopulationsofafricanancestry AT veenemansjacobien associationsbetweencommonvariantsinironrelatedgeneswithhaematologicaltraitsinpopulationsofafricanancestry AT talsmaelisef associationsbetweencommonvariantsinironrelatedgeneswithhaematologicaltraitsinpopulationsofafricanancestry AT harryvanjan associationsbetweencommonvariantsinironrelatedgeneswithhaematologicaltraitsinpopulationsofafricanancestry AT boekschotenmarkv associationsbetweencommonvariantsinironrelatedgeneswithhaematologicaltraitsinpopulationsofafricanancestry AT feskensedithjm associationsbetweencommonvariantsinironrelatedgeneswithhaematologicaltraitsinpopulationsofafricanancestry AT melseboonstraalida associationsbetweencommonvariantsinironrelatedgeneswithhaematologicaltraitsinpopulationsofafricanancestry |