East Coast fever caused by Theileria parva is characterized by macrophage activation associated with vasculitis and respiratory failure
Respiratory failure and death in East Coast Fever (ECF), a clinical syndrome of African cattle caused by the apicomplexan parasite Theileria parva, has historically been attributed to pulmonary infiltration by infected lymphocytes. However, immunohistochemical staining of tissue from T. parva infect...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
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Public Library of Science
2016
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/74287 |
| _version_ | 1855531060622786560 |
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| author | Fry, Lindsay M. Schneider, D.A. Frevert, C.W. Nelson, D.D. Morrison, W. Ivan Knowles, Donald P. |
| author_browse | Frevert, C.W. Fry, Lindsay M. Knowles, Donald P. Morrison, W. Ivan Nelson, D.D. Schneider, D.A. |
| author_facet | Fry, Lindsay M. Schneider, D.A. Frevert, C.W. Nelson, D.D. Morrison, W. Ivan Knowles, Donald P. |
| author_sort | Fry, Lindsay M. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Respiratory failure and death in East Coast Fever (ECF), a clinical syndrome of African cattle caused by the apicomplexan parasite Theileria parva, has historically been attributed to pulmonary infiltration by infected lymphocytes. However, immunohistochemical staining of tissue from T. parva infected cattle revealed large numbers of CD3- and CD20-negative intralesional mononuclear cells. Due to this finding, we hypothesized that macrophages play an important role in Theileria parva disease pathogenesis. Data presented here demonstrates that terminal ECF in both Holstein and Boran cattle is largely due to multisystemic histiocytic responses and resultant tissue damage. Furthermore, the combination of these histologic changes with the clinical findings, including lymphadenopathy, prolonged pyrexia, multi-lineage leukopenia, and thrombocytopenia is consistent with macrophage activation syndrome. All animals that succumbed to infection exhibited lymphohistiocytic vasculitis of small to medium caliber blood and lymphatic vessels. In pulmonary, lymphoid, splenic and hepatic tissues from Holstein cattle, the majority of intralesional macrophages were positive for CD163, and often expressed large amounts of IL-17. These data define a terminal ECF pathogenesis in which parasite-driven lymphoproliferation leads to secondary systemic macrophage activation syndrome, mononuclear vasculitis, pulmonary edema, respiratory failure and death. The accompanying macrophage phenotype defined by CD163 and IL-17 is presented in the context of this pathogenesis. |
| format | Journal Article |
| id | CGSpace74287 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2016 |
| publishDateRange | 2016 |
| publishDateSort | 2016 |
| publisher | Public Library of Science |
| publisherStr | Public Library of Science |
| record_format | dspace |
| spelling | CGSpace742872023-12-08T19:36:04Z East Coast fever caused by Theileria parva is characterized by macrophage activation associated with vasculitis and respiratory failure Fry, Lindsay M. Schneider, D.A. Frevert, C.W. Nelson, D.D. Morrison, W. Ivan Knowles, Donald P. theileria cattle animal diseases vaccines disease control east coast fever Respiratory failure and death in East Coast Fever (ECF), a clinical syndrome of African cattle caused by the apicomplexan parasite Theileria parva, has historically been attributed to pulmonary infiltration by infected lymphocytes. However, immunohistochemical staining of tissue from T. parva infected cattle revealed large numbers of CD3- and CD20-negative intralesional mononuclear cells. Due to this finding, we hypothesized that macrophages play an important role in Theileria parva disease pathogenesis. Data presented here demonstrates that terminal ECF in both Holstein and Boran cattle is largely due to multisystemic histiocytic responses and resultant tissue damage. Furthermore, the combination of these histologic changes with the clinical findings, including lymphadenopathy, prolonged pyrexia, multi-lineage leukopenia, and thrombocytopenia is consistent with macrophage activation syndrome. All animals that succumbed to infection exhibited lymphohistiocytic vasculitis of small to medium caliber blood and lymphatic vessels. In pulmonary, lymphoid, splenic and hepatic tissues from Holstein cattle, the majority of intralesional macrophages were positive for CD163, and often expressed large amounts of IL-17. These data define a terminal ECF pathogenesis in which parasite-driven lymphoproliferation leads to secondary systemic macrophage activation syndrome, mononuclear vasculitis, pulmonary edema, respiratory failure and death. The accompanying macrophage phenotype defined by CD163 and IL-17 is presented in the context of this pathogenesis. 2016-05-19 2016-05-23T10:48:39Z 2016-05-23T10:48:39Z Journal Article https://hdl.handle.net/10568/74287 en Open Access Public Library of Science Fry, L.M., Schneider, D.A., Frevert, C.W., Nelson, D.D., Morrison, W.I. and Knowles, D.P. 2016. East Coast fever caused by Theileria parva is characterized by macrophage activation associated with vasculitis and respiratory failure. PLoS One 11(5):e0156004. |
| spellingShingle | theileria cattle animal diseases vaccines disease control east coast fever Fry, Lindsay M. Schneider, D.A. Frevert, C.W. Nelson, D.D. Morrison, W. Ivan Knowles, Donald P. East Coast fever caused by Theileria parva is characterized by macrophage activation associated with vasculitis and respiratory failure |
| title | East Coast fever caused by Theileria parva is characterized by macrophage activation associated with vasculitis and respiratory failure |
| title_full | East Coast fever caused by Theileria parva is characterized by macrophage activation associated with vasculitis and respiratory failure |
| title_fullStr | East Coast fever caused by Theileria parva is characterized by macrophage activation associated with vasculitis and respiratory failure |
| title_full_unstemmed | East Coast fever caused by Theileria parva is characterized by macrophage activation associated with vasculitis and respiratory failure |
| title_short | East Coast fever caused by Theileria parva is characterized by macrophage activation associated with vasculitis and respiratory failure |
| title_sort | east coast fever caused by theileria parva is characterized by macrophage activation associated with vasculitis and respiratory failure |
| topic | theileria cattle animal diseases vaccines disease control east coast fever |
| url | https://hdl.handle.net/10568/74287 |
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