Biofortified yellow cassava and vitamin A status of Kenyan children: a randomized controlled trial
Background: Whereas conventional white cassava roots are devoid of provitamin A, biofortified yellow varieties are naturally rich in b-carotene, the primary provitamin A carotenoid. Objective: We assessed the effect of consuming yellow cassava on serum retinol concentration in Kenyan schoolchildren...
| Autores principales: | , , , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier
2016
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/73653 |
| _version_ | 1855537699681730560 |
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| author | Talsma, Elise F. Brouwer, Inge D. Verhoef, H. Mbera, G.N. Nwangi, A.M. Demir, Ayse Y. Maziya-Dixon, B.B. Boy, Erick Zimmermann, Michael B. Melse-Boonstra, Alida |
| author_browse | Boy, Erick Brouwer, Inge D. Demir, Ayse Y. Maziya-Dixon, B.B. Mbera, G.N. Melse-Boonstra, Alida Nwangi, A.M. Talsma, Elise F. Verhoef, H. Zimmermann, Michael B. |
| author_facet | Talsma, Elise F. Brouwer, Inge D. Verhoef, H. Mbera, G.N. Nwangi, A.M. Demir, Ayse Y. Maziya-Dixon, B.B. Boy, Erick Zimmermann, Michael B. Melse-Boonstra, Alida |
| author_sort | Talsma, Elise F. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Background: Whereas conventional white cassava roots are devoid of provitamin A, biofortified yellow varieties are naturally rich in b-carotene, the primary provitamin A carotenoid. Objective: We assessed the effect of consuming yellow cassava on serum retinol concentration in Kenyan schoolchildren with marginal vitamin A status. Design: We randomly allocated 342 children aged 5–13 y to receive daily, 6 d/wk, for 18.5 wk 1) white cassava and placebo supplement (control group), 2) provitamin A–rich cassava (mean content: 1460 mg b-carotene/d) and placebo supplement (yellow cassava group), and 3) white cassava and b-carotene supplement (1053 mg/d; b-carotene supplement group). The primary outcome was serum retinol concentration; prespecified secondary outcomes were hemoglobin concentration and serum concentrations of b-carotene, retinol-binding protein, and prealbumin. Groups were compared by using ANCOVA, adjusting for inflammation, baseline serum concentrations of retinol and b-carotene, and stratified design. Results: The baseline prevalence of serum retinol concentration, 0.7 mmol/L and inflammation was 27% and 24%, respectively. For children in the control, yellow cassava, and b-carotene supplement groups, the mean daily intake of cassava was 378, 371, and 378 g, respectively, and the total daily supply of provitamin A and vitamin A from diet and supplements was equivalent to 22, 220, and 175 mg retinol, respectively. Both yellow cassava and b-carotene supplementation increased serum retinol concentration by 0.04 mmol/L (95% CI: 0.00, 0.07 mmol/L); correspondingly, serum b-carotene concentration increased by 524% (448%, 608%) and 166% (134%, 202%). We found no effect on hemoglobin concentration or serum concentrations of retinol-binding protein and prealbumin. Conclusions: In our study population, consumption of yellow cassava led to modest gains in serum retinol concentration and a large increase in b-carotene concentration. It can be an efficacious, new approach to improve vitamin A status. This study was registered with clinicaltrials.gov as NCT01614483. |
| format | Journal Article |
| id | CGSpace73653 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2016 |
| publishDateRange | 2016 |
| publishDateSort | 2016 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | CGSpace736532025-11-12T04:48:32Z Biofortified yellow cassava and vitamin A status of Kenyan children: a randomized controlled trial Talsma, Elise F. Brouwer, Inge D. Verhoef, H. Mbera, G.N. Nwangi, A.M. Demir, Ayse Y. Maziya-Dixon, B.B. Boy, Erick Zimmermann, Michael B. Melse-Boonstra, Alida nutrition consumption vitamin a cassava biofortification nutrition-sensitive agriculture health retinol children experimental design Background: Whereas conventional white cassava roots are devoid of provitamin A, biofortified yellow varieties are naturally rich in b-carotene, the primary provitamin A carotenoid. Objective: We assessed the effect of consuming yellow cassava on serum retinol concentration in Kenyan schoolchildren with marginal vitamin A status. Design: We randomly allocated 342 children aged 5–13 y to receive daily, 6 d/wk, for 18.5 wk 1) white cassava and placebo supplement (control group), 2) provitamin A–rich cassava (mean content: 1460 mg b-carotene/d) and placebo supplement (yellow cassava group), and 3) white cassava and b-carotene supplement (1053 mg/d; b-carotene supplement group). The primary outcome was serum retinol concentration; prespecified secondary outcomes were hemoglobin concentration and serum concentrations of b-carotene, retinol-binding protein, and prealbumin. Groups were compared by using ANCOVA, adjusting for inflammation, baseline serum concentrations of retinol and b-carotene, and stratified design. Results: The baseline prevalence of serum retinol concentration, 0.7 mmol/L and inflammation was 27% and 24%, respectively. For children in the control, yellow cassava, and b-carotene supplement groups, the mean daily intake of cassava was 378, 371, and 378 g, respectively, and the total daily supply of provitamin A and vitamin A from diet and supplements was equivalent to 22, 220, and 175 mg retinol, respectively. Both yellow cassava and b-carotene supplementation increased serum retinol concentration by 0.04 mmol/L (95% CI: 0.00, 0.07 mmol/L); correspondingly, serum b-carotene concentration increased by 524% (448%, 608%) and 166% (134%, 202%). We found no effect on hemoglobin concentration or serum concentrations of retinol-binding protein and prealbumin. Conclusions: In our study population, consumption of yellow cassava led to modest gains in serum retinol concentration and a large increase in b-carotene concentration. It can be an efficacious, new approach to improve vitamin A status. This study was registered with clinicaltrials.gov as NCT01614483. 2016-01 2016-05-20T14:47:04Z 2016-05-20T14:47:04Z Journal Article https://hdl.handle.net/10568/73653 en https://doi.org/10.3945/ajcn.116.135483 https://doi.org/10.3945/ajcn.116.135715 https://doi.org/10.1093/ajcn/nqaa290 Open Access application/pdf Elsevier Talsma, E.F., Brouwer, I.D., Verhoef, H., Mbera, G.N., Mwangi, A.M., Demir, A.Y., ... & Melse-Boonstra, A. (2016). Biofortified yellow cassava and vitamin A status of Kenyan children: a randomized controlled trial. The American journal of clinical nutrition, 103(1), 258-267. |
| spellingShingle | nutrition consumption vitamin a cassava biofortification nutrition-sensitive agriculture health retinol children experimental design Talsma, Elise F. Brouwer, Inge D. Verhoef, H. Mbera, G.N. Nwangi, A.M. Demir, Ayse Y. Maziya-Dixon, B.B. Boy, Erick Zimmermann, Michael B. Melse-Boonstra, Alida Biofortified yellow cassava and vitamin A status of Kenyan children: a randomized controlled trial |
| title | Biofortified yellow cassava and vitamin A status of Kenyan children: a randomized controlled trial |
| title_full | Biofortified yellow cassava and vitamin A status of Kenyan children: a randomized controlled trial |
| title_fullStr | Biofortified yellow cassava and vitamin A status of Kenyan children: a randomized controlled trial |
| title_full_unstemmed | Biofortified yellow cassava and vitamin A status of Kenyan children: a randomized controlled trial |
| title_short | Biofortified yellow cassava and vitamin A status of Kenyan children: a randomized controlled trial |
| title_sort | biofortified yellow cassava and vitamin a status of kenyan children a randomized controlled trial |
| topic | nutrition consumption vitamin a cassava biofortification nutrition-sensitive agriculture health retinol children experimental design |
| url | https://hdl.handle.net/10568/73653 |
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