Evidence for negative selection of gene variants that increase dependence on dietary choline in a Gambian cohort
Choline is an essential nutrient, and the amount needed in the diet is modulated by several factors. Given geographical differences in dietary choline intake and disparate frequencies of single-nucleotide polymorphisms (SNPs) in choline metabolism genes between ethnic groups, we tested the hypothesi...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Wiley
2015
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| Online Access: | https://hdl.handle.net/10568/68515 |
| _version_ | 1855526075375812608 |
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| author | Silver, M.J. Corbin, K.D. Hellenthal, G. Costa, K.A. da Domínguez Salas, Paula Moore, S.E. Owen, J. Prentice, A.M. Hennig, B.J. Zeisel, S.H. |
| author_browse | Corbin, K.D. Costa, K.A. da Domínguez Salas, Paula Hellenthal, G. Hennig, B.J. Moore, S.E. Owen, J. Prentice, A.M. Silver, M.J. Zeisel, S.H. |
| author_facet | Silver, M.J. Corbin, K.D. Hellenthal, G. Costa, K.A. da Domínguez Salas, Paula Moore, S.E. Owen, J. Prentice, A.M. Hennig, B.J. Zeisel, S.H. |
| author_sort | Silver, M.J. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Choline is an essential nutrient, and the amount needed in the diet is modulated by several factors. Given geographical differences in dietary choline intake and disparate frequencies of single-nucleotide polymorphisms (SNPs) in choline metabolism genes between ethnic groups, we tested the hypothesis that 3 SNPs that increase dependence on dietary choline would be under negative selection pressure in settings where choline intake is low: choline dehydrogenase (CHDH) rs12676, methylenetetrahydrofolate reductase 1 (MTHFD1) rs2236225, and phosphatidylethanolamine-N-methyltransferase (PEMT) rs12325817. Evidence of negative selection was assessed in 2 populations: one in The Gambia, West Africa, where there is historic evidence of a choline-poor diet, and the other in the United States, with a comparatively choline-rich diet. We used 2 independent methods, and confirmation of our hypothesis was sought via a comparison with SNP data from the Maasai, an East African population with a genetic background similar to that of Gambians but with a traditional diet that is higher in choline. Our results show that frequencies of SNPs known to increase dependence on dietary choline are significantly reduced in the low-choline setting of The Gambia. Our findings suggest that adequate intake levels of choline may have to be reevaluated in different ethnic groups and highlight a possible approach for identifying novel functional SNPs under the influence of dietary selective pressure. |
| format | Journal Article |
| id | CGSpace68515 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Wiley |
| publisherStr | Wiley |
| record_format | dspace |
| spelling | CGSpace685152023-12-08T19:25:22Z Evidence for negative selection of gene variants that increase dependence on dietary choline in a Gambian cohort Silver, M.J. Corbin, K.D. Hellenthal, G. Costa, K.A. da Domínguez Salas, Paula Moore, S.E. Owen, J. Prentice, A.M. Hennig, B.J. Zeisel, S.H. Choline is an essential nutrient, and the amount needed in the diet is modulated by several factors. Given geographical differences in dietary choline intake and disparate frequencies of single-nucleotide polymorphisms (SNPs) in choline metabolism genes between ethnic groups, we tested the hypothesis that 3 SNPs that increase dependence on dietary choline would be under negative selection pressure in settings where choline intake is low: choline dehydrogenase (CHDH) rs12676, methylenetetrahydrofolate reductase 1 (MTHFD1) rs2236225, and phosphatidylethanolamine-N-methyltransferase (PEMT) rs12325817. Evidence of negative selection was assessed in 2 populations: one in The Gambia, West Africa, where there is historic evidence of a choline-poor diet, and the other in the United States, with a comparatively choline-rich diet. We used 2 independent methods, and confirmation of our hypothesis was sought via a comparison with SNP data from the Maasai, an East African population with a genetic background similar to that of Gambians but with a traditional diet that is higher in choline. Our results show that frequencies of SNPs known to increase dependence on dietary choline are significantly reduced in the low-choline setting of The Gambia. Our findings suggest that adequate intake levels of choline may have to be reevaluated in different ethnic groups and highlight a possible approach for identifying novel functional SNPs under the influence of dietary selective pressure. 2015-08 2015-10-13T12:33:05Z 2015-10-13T12:33:05Z Journal Article https://hdl.handle.net/10568/68515 en Open Access Wiley Silver, M.J., Corbin, K.D., Hellenthal, G., da Costa, K.-A., Dominguez-Salas, P., Moore, S.E., Owen, J., Prentice, A.M., Hennig, B.J. and Zeisel, S.H. 2015. Evidence for negative selection of gene variants that increase dependence on dietary choline in a Gambian cohort. The FASEB Journal 29(8): 3426-3435. |
| spellingShingle | Silver, M.J. Corbin, K.D. Hellenthal, G. Costa, K.A. da Domínguez Salas, Paula Moore, S.E. Owen, J. Prentice, A.M. Hennig, B.J. Zeisel, S.H. Evidence for negative selection of gene variants that increase dependence on dietary choline in a Gambian cohort |
| title | Evidence for negative selection of gene variants that increase dependence on dietary choline in a Gambian cohort |
| title_full | Evidence for negative selection of gene variants that increase dependence on dietary choline in a Gambian cohort |
| title_fullStr | Evidence for negative selection of gene variants that increase dependence on dietary choline in a Gambian cohort |
| title_full_unstemmed | Evidence for negative selection of gene variants that increase dependence on dietary choline in a Gambian cohort |
| title_short | Evidence for negative selection of gene variants that increase dependence on dietary choline in a Gambian cohort |
| title_sort | evidence for negative selection of gene variants that increase dependence on dietary choline in a gambian cohort |
| url | https://hdl.handle.net/10568/68515 |
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