Analysis of immune responses to recombinant proteins from strains of Mycoplasma mycoides subsp. mycoides, the causative agent of contagious Bovine pleuropneumonia
Current contagious bovine pleuropneumonia (CBPP) vaccines are based on live-attenuated strains of Mycoplasma mycoides subsp. mycoides (Mmm). These vaccines have shortcomings in terms of efficacy, duration of immunity and in some cases show severe side effects at the inoculation site; hence the need...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier
2015
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/68492 |
| _version_ | 1855535013805686784 |
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| author | Pérez Casal, J. Prysliak, T. Maina, T. Wang, Y. Townsend, H. Berverov, E. Nkando, I. Wesonga, H.O. Liljander, Anne M. Jores, Joerg Naessens, Jan Gerdts, V. Potter, A. |
| author_browse | Berverov, E. Gerdts, V. Jores, Joerg Liljander, Anne M. Maina, T. Naessens, Jan Nkando, I. Potter, A. Prysliak, T. Pérez Casal, J. Townsend, H. Wang, Y. Wesonga, H.O. |
| author_facet | Pérez Casal, J. Prysliak, T. Maina, T. Wang, Y. Townsend, H. Berverov, E. Nkando, I. Wesonga, H.O. Liljander, Anne M. Jores, Joerg Naessens, Jan Gerdts, V. Potter, A. |
| author_sort | Pérez Casal, J. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Current contagious bovine pleuropneumonia (CBPP) vaccines are based on live-attenuated strains of Mycoplasma mycoides subsp. mycoides (Mmm). These vaccines have shortcomings in terms of efficacy, duration of immunity and in some cases show severe side effects at the inoculation site; hence the need to develop new vaccines to combat the disease. Reverse vaccinology approaches were used and identified 66 candidate Mycoplasma proteins using available Mmm genome data. These proteins were ranked by their ability to be recognized by serum from CBPP-positive cattle and thereafter used to inoculate naïve cattle. We report here the inoculation of cattle with recombinant proteins and the subsequent humoral and T-cell-mediated immune responses to these proteins and conclude that a subset of these proteins are candidate molecules for recombinant protein-based subunit vaccines for CBPP control. |
| format | Journal Article |
| id | CGSpace68492 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | CGSpace684922024-05-01T08:18:53Z Analysis of immune responses to recombinant proteins from strains of Mycoplasma mycoides subsp. mycoides, the causative agent of contagious Bovine pleuropneumonia Pérez Casal, J. Prysliak, T. Maina, T. Wang, Y. Townsend, H. Berverov, E. Nkando, I. Wesonga, H.O. Liljander, Anne M. Jores, Joerg Naessens, Jan Gerdts, V. Potter, A. animal diseases cattle mycoplasma mycoides vaccination Current contagious bovine pleuropneumonia (CBPP) vaccines are based on live-attenuated strains of Mycoplasma mycoides subsp. mycoides (Mmm). These vaccines have shortcomings in terms of efficacy, duration of immunity and in some cases show severe side effects at the inoculation site; hence the need to develop new vaccines to combat the disease. Reverse vaccinology approaches were used and identified 66 candidate Mycoplasma proteins using available Mmm genome data. These proteins were ranked by their ability to be recognized by serum from CBPP-positive cattle and thereafter used to inoculate naïve cattle. We report here the inoculation of cattle with recombinant proteins and the subsequent humoral and T-cell-mediated immune responses to these proteins and conclude that a subset of these proteins are candidate molecules for recombinant protein-based subunit vaccines for CBPP control. 2015-11 2015-10-13T12:14:50Z 2015-10-13T12:14:50Z Journal Article https://hdl.handle.net/10568/68492 en Limited Access Elsevier Perez-Casal, J., Prysliak, T., Maina, T., Wang, Y., Townsend, H., Berverov, E., Nkando, I., Wesonga, H., Liljander, A., Jores, J., Naessens, J., Gerdts, V. and Potter, A. 2015. Analysis of immune responses to recombinant proteins from strains of Mycoplasma mycoides subsp. mycoides, the causative agent of contagious Bovine pleuropneumonia. Veterinary Immunology and Immunopathology 168(1–2): 103–110 |
| spellingShingle | animal diseases cattle mycoplasma mycoides vaccination Pérez Casal, J. Prysliak, T. Maina, T. Wang, Y. Townsend, H. Berverov, E. Nkando, I. Wesonga, H.O. Liljander, Anne M. Jores, Joerg Naessens, Jan Gerdts, V. Potter, A. Analysis of immune responses to recombinant proteins from strains of Mycoplasma mycoides subsp. mycoides, the causative agent of contagious Bovine pleuropneumonia |
| title | Analysis of immune responses to recombinant proteins from strains of Mycoplasma mycoides subsp. mycoides, the causative agent of contagious Bovine pleuropneumonia |
| title_full | Analysis of immune responses to recombinant proteins from strains of Mycoplasma mycoides subsp. mycoides, the causative agent of contagious Bovine pleuropneumonia |
| title_fullStr | Analysis of immune responses to recombinant proteins from strains of Mycoplasma mycoides subsp. mycoides, the causative agent of contagious Bovine pleuropneumonia |
| title_full_unstemmed | Analysis of immune responses to recombinant proteins from strains of Mycoplasma mycoides subsp. mycoides, the causative agent of contagious Bovine pleuropneumonia |
| title_short | Analysis of immune responses to recombinant proteins from strains of Mycoplasma mycoides subsp. mycoides, the causative agent of contagious Bovine pleuropneumonia |
| title_sort | analysis of immune responses to recombinant proteins from strains of mycoplasma mycoides subsp mycoides the causative agent of contagious bovine pleuropneumonia |
| topic | animal diseases cattle mycoplasma mycoides vaccination |
| url | https://hdl.handle.net/10568/68492 |
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