The genome of the blood fluke Schistosoma mansoni
Schistosoma mansoni is responsible for the neglected tropical disease schistosomiasis that affects 210 million people in 76 countries. Here we present analysis of the 363 megabase nuclear genome of the blood fluke. It encodes at least 11,809 genes, with an unusual intron size distribution, and new f...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Springer
2009
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/68366 |
| _version_ | 1855517341562961920 |
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| author | Berriman, M. Haas, B.J. LoVerde, P.T. Wilson, R.A. Dillon, G.P. Cerqueira, G.C. Mashiyama, S.T. Al-Lazikani, B. Andrade, L.F. Ashton, P.D. Aslett, M.A. Bartholomeu, D.C. Blandin, G. Caffrey, C.R. Coghlan, A. Coulson, R. Day, T.A. Delcher, A. DeMarco, R. Djikeng, Appolinaire Eyre, T. Gamble, J.A. Ghedin, E. Gu, Y. Hertz-Fowler, C. Hirai, H. Hirai, Y. Houston, R. Ivens, A. Johnston, D.A. Lacerda, D. Macedo, C.D. McVeigh, P. Ning, Z. Oliveira, G. Overington, J.P. Parkhill, J. Pertea, M. Pierce, R.J. Protasio, A.V. Quail, M.A. Rajandream, M.A. Rogers, J. Sajid, M. Salzberg, S.L. Stanke, M. Tivey, A.R. White, O. Williams, D.L. Wortman, Jennifer R. Wu, W. Zamanian, M. Zerlotini, A. Fraser-Liggett, C.M. Barrell, B.G. El-Sayed, N.M. |
| author_browse | Al-Lazikani, B. Andrade, L.F. Ashton, P.D. Aslett, M.A. Barrell, B.G. Bartholomeu, D.C. Berriman, M. Blandin, G. Caffrey, C.R. Cerqueira, G.C. Coghlan, A. Coulson, R. Day, T.A. DeMarco, R. Delcher, A. Dillon, G.P. Djikeng, Appolinaire El-Sayed, N.M. Eyre, T. Fraser-Liggett, C.M. Gamble, J.A. Ghedin, E. Gu, Y. Haas, B.J. Hertz-Fowler, C. Hirai, H. Hirai, Y. Houston, R. Ivens, A. Johnston, D.A. Lacerda, D. LoVerde, P.T. Macedo, C.D. Mashiyama, S.T. McVeigh, P. Ning, Z. Oliveira, G. Overington, J.P. Parkhill, J. Pertea, M. Pierce, R.J. Protasio, A.V. Quail, M.A. Rajandream, M.A. Rogers, J. Sajid, M. Salzberg, S.L. Stanke, M. Tivey, A.R. White, O. Williams, D.L. Wilson, R.A. Wortman, Jennifer R. Wu, W. Zamanian, M. Zerlotini, A. |
| author_facet | Berriman, M. Haas, B.J. LoVerde, P.T. Wilson, R.A. Dillon, G.P. Cerqueira, G.C. Mashiyama, S.T. Al-Lazikani, B. Andrade, L.F. Ashton, P.D. Aslett, M.A. Bartholomeu, D.C. Blandin, G. Caffrey, C.R. Coghlan, A. Coulson, R. Day, T.A. Delcher, A. DeMarco, R. Djikeng, Appolinaire Eyre, T. Gamble, J.A. Ghedin, E. Gu, Y. Hertz-Fowler, C. Hirai, H. Hirai, Y. Houston, R. Ivens, A. Johnston, D.A. Lacerda, D. Macedo, C.D. McVeigh, P. Ning, Z. Oliveira, G. Overington, J.P. Parkhill, J. Pertea, M. Pierce, R.J. Protasio, A.V. Quail, M.A. Rajandream, M.A. Rogers, J. Sajid, M. Salzberg, S.L. Stanke, M. Tivey, A.R. White, O. Williams, D.L. Wortman, Jennifer R. Wu, W. Zamanian, M. Zerlotini, A. Fraser-Liggett, C.M. Barrell, B.G. El-Sayed, N.M. |
| author_sort | Berriman, M. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Schistosoma mansoni is responsible for the neglected tropical disease schistosomiasis that affects 210 million people in 76 countries. Here we present analysis of the 363 megabase nuclear genome of the blood fluke. It encodes at least 11,809 genes, with an unusual intron size distribution, and new families of micro-exon genes that undergo frequent alternative splicing. As the first sequenced flatworm, and a representative of the Lophotrochozoa, it offers insights into early events in the evolution of the animals, including the development of a body pattern with bilateral symmetry, and the development of tissues into organs. Our analysis has been informed by the need to find new drug targets. The deficits in lipid metabolism that make schistosomes dependent on the host are revealed, and the identification of membrane receptors, ion channels and more than 300 proteases provide new insights into the biology of the life cycle and new targets. Bioinformatics approaches have identified metabolic chokepoints, and a chemogenomic screen has pinpointed schistosome proteins for which existing drugs may be active. The information generated provides an invaluable resource for the research community to develop much needed new control tools for the treatment and eradication of this important and neglected disease. |
| format | Journal Article |
| id | CGSpace68366 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2009 |
| publishDateRange | 2009 |
| publishDateSort | 2009 |
| publisher | Springer |
| publisherStr | Springer |
| record_format | dspace |
| spelling | CGSpace683662024-08-27T10:35:03Z The genome of the blood fluke Schistosoma mansoni Berriman, M. Haas, B.J. LoVerde, P.T. Wilson, R.A. Dillon, G.P. Cerqueira, G.C. Mashiyama, S.T. Al-Lazikani, B. Andrade, L.F. Ashton, P.D. Aslett, M.A. Bartholomeu, D.C. Blandin, G. Caffrey, C.R. Coghlan, A. Coulson, R. Day, T.A. Delcher, A. DeMarco, R. Djikeng, Appolinaire Eyre, T. Gamble, J.A. Ghedin, E. Gu, Y. Hertz-Fowler, C. Hirai, H. Hirai, Y. Houston, R. Ivens, A. Johnston, D.A. Lacerda, D. Macedo, C.D. McVeigh, P. Ning, Z. Oliveira, G. Overington, J.P. Parkhill, J. Pertea, M. Pierce, R.J. Protasio, A.V. Quail, M.A. Rajandream, M.A. Rogers, J. Sajid, M. Salzberg, S.L. Stanke, M. Tivey, A.R. White, O. Williams, D.L. Wortman, Jennifer R. Wu, W. Zamanian, M. Zerlotini, A. Fraser-Liggett, C.M. Barrell, B.G. El-Sayed, N.M. schistosoma health Schistosoma mansoni is responsible for the neglected tropical disease schistosomiasis that affects 210 million people in 76 countries. Here we present analysis of the 363 megabase nuclear genome of the blood fluke. It encodes at least 11,809 genes, with an unusual intron size distribution, and new families of micro-exon genes that undergo frequent alternative splicing. As the first sequenced flatworm, and a representative of the Lophotrochozoa, it offers insights into early events in the evolution of the animals, including the development of a body pattern with bilateral symmetry, and the development of tissues into organs. Our analysis has been informed by the need to find new drug targets. The deficits in lipid metabolism that make schistosomes dependent on the host are revealed, and the identification of membrane receptors, ion channels and more than 300 proteases provide new insights into the biology of the life cycle and new targets. Bioinformatics approaches have identified metabolic chokepoints, and a chemogenomic screen has pinpointed schistosome proteins for which existing drugs may be active. The information generated provides an invaluable resource for the research community to develop much needed new control tools for the treatment and eradication of this important and neglected disease. 2009-07 2015-09-30T10:55:55Z 2015-09-30T10:55:55Z Journal Article https://hdl.handle.net/10568/68366 en Open Access Springer Berriman, M., Haas, B.J., LoVerde, P.T., Wilson, R.A., Dillon, G.P., Cerqueira, G.C., Mashiyama, S.T., Al-Lazikani, B., Andrade, L.F., Ashton, P.D., Aslett, M.A., Bartholomeu, D.C., Blandin, G., Caffrey, C.R., Coghlan, A., Coulson, R., Day, T.A., Delcher, A., DeMarco, R., Djikeng, A., Eyre, T., Gamble, J.A., Ghedin, E., Gu, Y., Hertz-Fowler, C., Hirai, H., Hirai Y, Houston R, Ivens A, Johnston DA, Lacerda D, Macedo CD, McVeigh P, Ning, Z., Oliveira, G., Overington, J.P., Parkhill, J., Pertea, M., Pierce, R.J., Protasio, A.V., Quail, M.A., Rajandream, M.A., Rogers, J., Sajid, M., Salzberg, S.L., Stanke, M., Tivey, A.R., White, O., Williams, D.L., Wortman, J., Wu, W., Zamanian, M., Zerlotini, A., Fraser-Liggett, C.M., Barrell, B.G. and El-Sayed, N.M. 2009. The genome of the blood fluke Schistosoma mansoni. Nature 460:352-358. |
| spellingShingle | schistosoma health Berriman, M. Haas, B.J. LoVerde, P.T. Wilson, R.A. Dillon, G.P. Cerqueira, G.C. Mashiyama, S.T. Al-Lazikani, B. Andrade, L.F. Ashton, P.D. Aslett, M.A. Bartholomeu, D.C. Blandin, G. Caffrey, C.R. Coghlan, A. Coulson, R. Day, T.A. Delcher, A. DeMarco, R. Djikeng, Appolinaire Eyre, T. Gamble, J.A. Ghedin, E. Gu, Y. Hertz-Fowler, C. Hirai, H. Hirai, Y. Houston, R. Ivens, A. Johnston, D.A. Lacerda, D. Macedo, C.D. McVeigh, P. Ning, Z. Oliveira, G. Overington, J.P. Parkhill, J. Pertea, M. Pierce, R.J. Protasio, A.V. Quail, M.A. Rajandream, M.A. Rogers, J. Sajid, M. Salzberg, S.L. Stanke, M. Tivey, A.R. White, O. Williams, D.L. Wortman, Jennifer R. Wu, W. Zamanian, M. Zerlotini, A. Fraser-Liggett, C.M. Barrell, B.G. El-Sayed, N.M. The genome of the blood fluke Schistosoma mansoni |
| title | The genome of the blood fluke Schistosoma mansoni |
| title_full | The genome of the blood fluke Schistosoma mansoni |
| title_fullStr | The genome of the blood fluke Schistosoma mansoni |
| title_full_unstemmed | The genome of the blood fluke Schistosoma mansoni |
| title_short | The genome of the blood fluke Schistosoma mansoni |
| title_sort | genome of the blood fluke schistosoma mansoni |
| topic | schistosoma health |
| url | https://hdl.handle.net/10568/68366 |
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