Sequencing and analyses of all known human rhinovirus genomes reveal structure and evolution
Infection by human rhinovirus (HRV) is a major cause of upper and lower respiratory tract disease worldwide and displays considerable phenotypic variation. We examined diversity by completing the genome sequences for all known serotypes (n = 99). Superimposition of capsid crystal structure and optim...
| Autores principales: | , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
American Association for the Advancement of Science
2009
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/68364 |
| _version_ | 1855516840413888512 |
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| author | Palmenberg, A.C. Spiro, D. Kuzmickas, R. Wang, S. Djikeng, Appolinaire Rathe, J.A. Fraser-Liggett, C.M. Liggett, S.B. |
| author_browse | Djikeng, Appolinaire Fraser-Liggett, C.M. Kuzmickas, R. Liggett, S.B. Palmenberg, A.C. Rathe, J.A. Spiro, D. Wang, S. |
| author_facet | Palmenberg, A.C. Spiro, D. Kuzmickas, R. Wang, S. Djikeng, Appolinaire Rathe, J.A. Fraser-Liggett, C.M. Liggett, S.B. |
| author_sort | Palmenberg, A.C. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Infection by human rhinovirus (HRV) is a major cause of upper and lower respiratory tract disease worldwide and displays considerable phenotypic variation. We examined diversity by completing the genome sequences for all known serotypes (n = 99). Superimposition of capsid crystal structure and optimal-energy RNA configurations established alignments and phylogeny. These revealed conserved motifs; clade-specific diversity, including a potential newly identified species (HRV-D); mutations in field isolates; and recombination. In analogy with poliovirus, a hypervariable 5? untranslated region tract may affect virulence. A configuration consistent with nonscanning internal ribosome entry was found in all HRVs and may account for rapid translation. The data density from complete sequences of the reference HRVs provided high resolution for this degree of modeling and serves as a platform for full genome-based epidemiologic studies and antiviral or vaccine development. |
| format | Journal Article |
| id | CGSpace68364 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2009 |
| publishDateRange | 2009 |
| publishDateSort | 2009 |
| publisher | American Association for the Advancement of Science |
| publisherStr | American Association for the Advancement of Science |
| record_format | dspace |
| spelling | CGSpace683642023-12-08T19:36:04Z Sequencing and analyses of all known human rhinovirus genomes reveal structure and evolution Palmenberg, A.C. Spiro, D. Kuzmickas, R. Wang, S. Djikeng, Appolinaire Rathe, J.A. Fraser-Liggett, C.M. Liggett, S.B. health vaccines Infection by human rhinovirus (HRV) is a major cause of upper and lower respiratory tract disease worldwide and displays considerable phenotypic variation. We examined diversity by completing the genome sequences for all known serotypes (n = 99). Superimposition of capsid crystal structure and optimal-energy RNA configurations established alignments and phylogeny. These revealed conserved motifs; clade-specific diversity, including a potential newly identified species (HRV-D); mutations in field isolates; and recombination. In analogy with poliovirus, a hypervariable 5? untranslated region tract may affect virulence. A configuration consistent with nonscanning internal ribosome entry was found in all HRVs and may account for rapid translation. The data density from complete sequences of the reference HRVs provided high resolution for this degree of modeling and serves as a platform for full genome-based epidemiologic studies and antiviral or vaccine development. 2009-04-03 2015-09-30T10:55:55Z 2015-09-30T10:55:55Z Journal Article https://hdl.handle.net/10568/68364 en Limited Access American Association for the Advancement of Science Palmenberg, A.C., Spiro, D., Kuzmickas, R., Wang, S., Djikeng, A., Rathe, J.A., Fraser-Liggett, C.M. and Liggett, S.B. 2009. Sequencing and analyses of all known human rhinovirus genomes reveal structure and evolution. Science 324 (5923): 55-59. |
| spellingShingle | health vaccines Palmenberg, A.C. Spiro, D. Kuzmickas, R. Wang, S. Djikeng, Appolinaire Rathe, J.A. Fraser-Liggett, C.M. Liggett, S.B. Sequencing and analyses of all known human rhinovirus genomes reveal structure and evolution |
| title | Sequencing and analyses of all known human rhinovirus genomes reveal structure and evolution |
| title_full | Sequencing and analyses of all known human rhinovirus genomes reveal structure and evolution |
| title_fullStr | Sequencing and analyses of all known human rhinovirus genomes reveal structure and evolution |
| title_full_unstemmed | Sequencing and analyses of all known human rhinovirus genomes reveal structure and evolution |
| title_short | Sequencing and analyses of all known human rhinovirus genomes reveal structure and evolution |
| title_sort | sequencing and analyses of all known human rhinovirus genomes reveal structure and evolution |
| topic | health vaccines |
| url | https://hdl.handle.net/10568/68364 |
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