Variation and covariation in strongyle infection in East African shorthorn zebu calves
Parasite burden varies widely between individuals within a population, and can covary with multiple aspects of individual phenotype. Here we investigate the sources of variation in faecal strongyle eggs counts, and its association with body weight and a suite of haematological measures, in a cohort...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Cambridge University Press
2015
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/67376 |
| _version_ | 1855523867820294144 |
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| author | Callaby, R. Hanotte, Olivier H. Wyk, Ilana Conradie van Kiara, Henry K. Toye, Philip G. Mbole-Kariuki, Mary N. Jennings, A. Thumbi, Samuel M. Coetzer, Jacobus A.W. Bronsvoort, B.M. de C. Knott, S.A. Woolhouse, Mark E.J. Kruuk, L.E.B. |
| author_browse | Bronsvoort, B.M. de C. Callaby, R. Coetzer, Jacobus A.W. Hanotte, Olivier H. Jennings, A. Kiara, Henry K. Knott, S.A. Kruuk, L.E.B. Mbole-Kariuki, Mary N. Thumbi, Samuel M. Toye, Philip G. Woolhouse, Mark E.J. Wyk, Ilana Conradie van |
| author_facet | Callaby, R. Hanotte, Olivier H. Wyk, Ilana Conradie van Kiara, Henry K. Toye, Philip G. Mbole-Kariuki, Mary N. Jennings, A. Thumbi, Samuel M. Coetzer, Jacobus A.W. Bronsvoort, B.M. de C. Knott, S.A. Woolhouse, Mark E.J. Kruuk, L.E.B. |
| author_sort | Callaby, R. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Parasite burden varies widely between individuals within a population, and can covary with multiple aspects of individual phenotype. Here we investigate the sources of variation in faecal strongyle eggs counts, and its association with body weight and a suite of haematological measures, in a cohort of indigenous zebu calves in Western Kenya, using relatedness matrices reconstructed from single nucleotide polymorphism (SNP) genotypes. Strongyle egg count was heritable (h2 = 23·9%, s.e. = 11·8%) and we also found heritability of white blood cell counts (WBC) (h2 = 27·6%, s.e. = 10·6%). All the traits investigated showed negative phenotypic covariances with strongyle egg count throughout the first year: high worm counts were associated with low values of WBC, red blood cell count, total serum protein and absolute eosinophil count. Furthermore, calf body weight at 1 week old was a significant predictor of strongyle EPG at 16–51 weeks, with smaller calves having a higher strongyle egg count later in life. Our results indicate a genetic basis to strongyle EPG in this population, and also reveal consistently strong negative associations between strongyle infection and other important aspects of the multivariate phenotype. |
| format | Journal Article |
| id | CGSpace67376 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Cambridge University Press |
| publisherStr | Cambridge University Press |
| record_format | dspace |
| spelling | CGSpace673762024-04-25T06:00:52Z Variation and covariation in strongyle infection in East African shorthorn zebu calves Callaby, R. Hanotte, Olivier H. Wyk, Ilana Conradie van Kiara, Henry K. Toye, Philip G. Mbole-Kariuki, Mary N. Jennings, A. Thumbi, Samuel M. Coetzer, Jacobus A.W. Bronsvoort, B.M. de C. Knott, S.A. Woolhouse, Mark E.J. Kruuk, L.E.B. animal diseases animal breeding Parasite burden varies widely between individuals within a population, and can covary with multiple aspects of individual phenotype. Here we investigate the sources of variation in faecal strongyle eggs counts, and its association with body weight and a suite of haematological measures, in a cohort of indigenous zebu calves in Western Kenya, using relatedness matrices reconstructed from single nucleotide polymorphism (SNP) genotypes. Strongyle egg count was heritable (h2 = 23·9%, s.e. = 11·8%) and we also found heritability of white blood cell counts (WBC) (h2 = 27·6%, s.e. = 10·6%). All the traits investigated showed negative phenotypic covariances with strongyle egg count throughout the first year: high worm counts were associated with low values of WBC, red blood cell count, total serum protein and absolute eosinophil count. Furthermore, calf body weight at 1 week old was a significant predictor of strongyle EPG at 16–51 weeks, with smaller calves having a higher strongyle egg count later in life. Our results indicate a genetic basis to strongyle EPG in this population, and also reveal consistently strong negative associations between strongyle infection and other important aspects of the multivariate phenotype. 2015-03 2015-07-27T07:48:03Z 2015-07-27T07:48:03Z Journal Article https://hdl.handle.net/10568/67376 en Open Access Cambridge University Press Callaby, R., Hanotte, O., Wyk, I.C. van, Kiara, H., Toye, P.G., Mbole-Kariuk, M.N., Jennings, A., Thumbi, S.M., Coetzer, J.A.W., Bronsvoort, B.M. De. C., Knott, S.A., Woolhouse, M.E.J. and Kruuk, L.E.B. 2015. Variation and covariation in strongyle infection in East African shorthorn zebu calves. Parasitology 142(3):499-511. |
| spellingShingle | animal diseases animal breeding Callaby, R. Hanotte, Olivier H. Wyk, Ilana Conradie van Kiara, Henry K. Toye, Philip G. Mbole-Kariuki, Mary N. Jennings, A. Thumbi, Samuel M. Coetzer, Jacobus A.W. Bronsvoort, B.M. de C. Knott, S.A. Woolhouse, Mark E.J. Kruuk, L.E.B. Variation and covariation in strongyle infection in East African shorthorn zebu calves |
| title | Variation and covariation in strongyle infection in East African shorthorn zebu calves |
| title_full | Variation and covariation in strongyle infection in East African shorthorn zebu calves |
| title_fullStr | Variation and covariation in strongyle infection in East African shorthorn zebu calves |
| title_full_unstemmed | Variation and covariation in strongyle infection in East African shorthorn zebu calves |
| title_short | Variation and covariation in strongyle infection in East African shorthorn zebu calves |
| title_sort | variation and covariation in strongyle infection in east african shorthorn zebu calves |
| topic | animal diseases animal breeding |
| url | https://hdl.handle.net/10568/67376 |
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