Exposure of vaccinated and naive cattle to natural challenge from buffalo-derived Theileria parva
Integrative management of wildlife and livestock requires a clear understanding of the diseases transmitted between the two populations. The tick-borne protozoan parasite Theileria parva causes two distinct diseases in cattle, East Coast fever and Corridor disease, following infection with parasites...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier
2015
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/66148 |
| _version_ | 1855523867637841920 |
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| author | Sitt, Tatjana Poole, Elizabeth J. Ndambuki, Gideon M. Mwaura, S. Njoroge, T. Omondi, G.P. Mutinda, M. Mathenge, J. Prettejohn, G. Morrison, W. Ivan Toye, Philip G. |
| author_browse | Mathenge, J. Morrison, W. Ivan Mutinda, M. Mwaura, S. Ndambuki, Gideon M. Njoroge, T. Omondi, G.P. Poole, Elizabeth J. Prettejohn, G. Sitt, Tatjana Toye, Philip G. |
| author_facet | Sitt, Tatjana Poole, Elizabeth J. Ndambuki, Gideon M. Mwaura, S. Njoroge, T. Omondi, G.P. Mutinda, M. Mathenge, J. Prettejohn, G. Morrison, W. Ivan Toye, Philip G. |
| author_sort | Sitt, Tatjana |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Integrative management of wildlife and livestock requires a clear understanding of the diseases transmitted between the two populations. The tick-borne protozoan parasite Theileria parva causes two distinct diseases in cattle, East Coast fever and Corridor disease, following infection with parasites derived from cattle or buffalo, respectively. In this study, cattle were immunized with a live sporozoite vaccine containing three T. parva isolates (the Muguga cocktail), which has been used extensively and successfully in the field to protect against cattle-derived T. parva infection. The cattle were exposed in a natural field challenge site containing buffalo but no other cattle. The vaccine had no effect on the survival outcome in vaccinated animals compared to unvaccinated controls: nine out of the 12 cattle in each group succumbed to T. parva infection. The vaccine also had no effect on the clinical course of the disease. A combination of clinical and post mortem observations and laboratory analyses confirmed that the animals died of Corridor disease. The results clearly indicate that the Muguga cocktail vaccine does not provide protection against buffalo-derived T. parva at this site and highlight the need to evaluate the impact of the composition of challenge T. parva populations on vaccine success in areas where buffalo and cattle are present. |
| format | Journal Article |
| id | CGSpace66148 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | CGSpace661482025-02-27T08:45:21Z Exposure of vaccinated and naive cattle to natural challenge from buffalo-derived Theileria parva Sitt, Tatjana Poole, Elizabeth J. Ndambuki, Gideon M. Mwaura, S. Njoroge, T. Omondi, G.P. Mutinda, M. Mathenge, J. Prettejohn, G. Morrison, W. Ivan Toye, Philip G. animal diseases disease control Integrative management of wildlife and livestock requires a clear understanding of the diseases transmitted between the two populations. The tick-borne protozoan parasite Theileria parva causes two distinct diseases in cattle, East Coast fever and Corridor disease, following infection with parasites derived from cattle or buffalo, respectively. In this study, cattle were immunized with a live sporozoite vaccine containing three T. parva isolates (the Muguga cocktail), which has been used extensively and successfully in the field to protect against cattle-derived T. parva infection. The cattle were exposed in a natural field challenge site containing buffalo but no other cattle. The vaccine had no effect on the survival outcome in vaccinated animals compared to unvaccinated controls: nine out of the 12 cattle in each group succumbed to T. parva infection. The vaccine also had no effect on the clinical course of the disease. A combination of clinical and post mortem observations and laboratory analyses confirmed that the animals died of Corridor disease. The results clearly indicate that the Muguga cocktail vaccine does not provide protection against buffalo-derived T. parva at this site and highlight the need to evaluate the impact of the composition of challenge T. parva populations on vaccine success in areas where buffalo and cattle are present. 2015-08-01 2015-05-19T07:24:39Z 2015-05-19T07:24:39Z Journal Article https://hdl.handle.net/10568/66148 en Open Access Elsevier Sitt, T., Poole, E.J., Ndambuk, G., Mwaura, S., Njoroge, T., Omondi, G.P., Mutinda, M., Mathenge, J., Prettejohn, G., Morrison, W.I. and Toye, P. 2015. Exposure of vaccinated and naive cattle to natural challenge from buffalo-derived Theileria parva. International Journal for Parasitology: Parasites and Wildlife 4(2):244–251. |
| spellingShingle | animal diseases disease control Sitt, Tatjana Poole, Elizabeth J. Ndambuki, Gideon M. Mwaura, S. Njoroge, T. Omondi, G.P. Mutinda, M. Mathenge, J. Prettejohn, G. Morrison, W. Ivan Toye, Philip G. Exposure of vaccinated and naive cattle to natural challenge from buffalo-derived Theileria parva |
| title | Exposure of vaccinated and naive cattle to natural challenge from buffalo-derived Theileria parva |
| title_full | Exposure of vaccinated and naive cattle to natural challenge from buffalo-derived Theileria parva |
| title_fullStr | Exposure of vaccinated and naive cattle to natural challenge from buffalo-derived Theileria parva |
| title_full_unstemmed | Exposure of vaccinated and naive cattle to natural challenge from buffalo-derived Theileria parva |
| title_short | Exposure of vaccinated and naive cattle to natural challenge from buffalo-derived Theileria parva |
| title_sort | exposure of vaccinated and naive cattle to natural challenge from buffalo derived theileria parva |
| topic | animal diseases disease control |
| url | https://hdl.handle.net/10568/66148 |
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