The epidemiology of animal bite injuries in Uganda and projections of the burden of rabies
Objectives Rabies is a global problem, although it is often under‐reported in developing countries. We aimed at describing the profile of patients presenting to health centres with animal bite injuries in Uganda, and use a predictive model to estimate the mortality of rabies at a national level.Met...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
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Wiley
2005
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| Online Access: | https://hdl.handle.net/10568/61881 |
| _version_ | 1855538312750563328 |
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| author | Fèvre, Eric M. Kaboyo, R.W. Persson, V. Edelsten, M. Coleman, P.G. Cleaveland, S. |
| author_browse | Cleaveland, S. Coleman, P.G. Edelsten, M. Fèvre, Eric M. Kaboyo, R.W. Persson, V. |
| author_facet | Fèvre, Eric M. Kaboyo, R.W. Persson, V. Edelsten, M. Coleman, P.G. Cleaveland, S. |
| author_sort | Fèvre, Eric M. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Objectives Rabies is a global problem, although it is often under‐reported in developing countries. We aimed at describing the profile of patients presenting to health centres with animal bite injuries in Uganda, and use a predictive model to estimate the mortality of rabies at a national level.Methods We conducted a passive surveillance study in Uganda based in a random sample of health centres supplied with rabies vaccine to determine the characteristics of bite injury patients and establish the age and sex profiles of patients, the site of bites and their severity, wound management techniques and details of the vaccination course given. We also applied a decision tree model to the data to estimate the rabies mortality from the bite injury data using an established protocol.Results We found that most patients are bitten by dogs, and that a considerable proportion of these are young children, who are at greater risk of developing rabies in the absence of treatment due to the location of the bites they receive. From conservative parameter estimates, we estimate that in the absence of post‐exposure prophylaxis (PET), 592 (95% CI 345–920) deaths would occur, and that if one dose of PET is sufficient for protection following a rabid animal bite, 20 (95% CI 5–50) deaths would occur annually. If a complete course of PET is required for protection following a rabid animal bite, up to 210 (95% CI 115–359) deaths would occur, as 41% of patients did not complete their course of PET.Conclusions Active animal bite surveillance studies are required to improve our mortality estimates and determine the true burden of rabies in the Ugandan population. We emphasize the need for small‐scale active case detection studies and improved data on the recognition of rabies in dogs as inputs for improving national‐level estimates of rabies mortality. |
| format | Journal Article |
| id | CGSpace61881 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2005 |
| publishDateRange | 2005 |
| publishDateSort | 2005 |
| publisher | Wiley |
| publisherStr | Wiley |
| record_format | dspace |
| spelling | CGSpace618812024-05-01T08:19:24Z The epidemiology of animal bite injuries in Uganda and projections of the burden of rabies Fèvre, Eric M. Kaboyo, R.W. Persson, V. Edelsten, M. Coleman, P.G. Cleaveland, S. disease control animal diseases zoonoses Objectives Rabies is a global problem, although it is often under‐reported in developing countries. We aimed at describing the profile of patients presenting to health centres with animal bite injuries in Uganda, and use a predictive model to estimate the mortality of rabies at a national level.Methods We conducted a passive surveillance study in Uganda based in a random sample of health centres supplied with rabies vaccine to determine the characteristics of bite injury patients and establish the age and sex profiles of patients, the site of bites and their severity, wound management techniques and details of the vaccination course given. We also applied a decision tree model to the data to estimate the rabies mortality from the bite injury data using an established protocol.Results We found that most patients are bitten by dogs, and that a considerable proportion of these are young children, who are at greater risk of developing rabies in the absence of treatment due to the location of the bites they receive. From conservative parameter estimates, we estimate that in the absence of post‐exposure prophylaxis (PET), 592 (95% CI 345–920) deaths would occur, and that if one dose of PET is sufficient for protection following a rabid animal bite, 20 (95% CI 5–50) deaths would occur annually. If a complete course of PET is required for protection following a rabid animal bite, up to 210 (95% CI 115–359) deaths would occur, as 41% of patients did not complete their course of PET.Conclusions Active animal bite surveillance studies are required to improve our mortality estimates and determine the true burden of rabies in the Ugandan population. We emphasize the need for small‐scale active case detection studies and improved data on the recognition of rabies in dogs as inputs for improving national‐level estimates of rabies mortality. 2005-08 2015-03-25T09:09:40Z 2015-03-25T09:09:40Z Journal Article https://hdl.handle.net/10568/61881 en Limited Access Wiley Tropical Medicine & International Health;10(8):790-8. |
| spellingShingle | disease control animal diseases zoonoses Fèvre, Eric M. Kaboyo, R.W. Persson, V. Edelsten, M. Coleman, P.G. Cleaveland, S. The epidemiology of animal bite injuries in Uganda and projections of the burden of rabies |
| title | The epidemiology of animal bite injuries in Uganda and projections of the burden of rabies |
| title_full | The epidemiology of animal bite injuries in Uganda and projections of the burden of rabies |
| title_fullStr | The epidemiology of animal bite injuries in Uganda and projections of the burden of rabies |
| title_full_unstemmed | The epidemiology of animal bite injuries in Uganda and projections of the burden of rabies |
| title_short | The epidemiology of animal bite injuries in Uganda and projections of the burden of rabies |
| title_sort | epidemiology of animal bite injuries in uganda and projections of the burden of rabies |
| topic | disease control animal diseases zoonoses |
| url | https://hdl.handle.net/10568/61881 |
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